Optimal descriptor as a translator of eclectic data into prediction of cytotoxicity for metal oxide nanoparticles under different conditions

Alla P. Toropova, Andrey A. Toropov, Robert Rallo, Danuta Leszczynska, Jerzy Leszczynski

Research output: Contribution to journalArticle

Abstract

The Monte Carlo technique has been used to build up quantitative structure-activity relationships (QSARs) for prediction of dark cytotoxicity and photo-induced cytotoxicity of metal oxide nanoparticles to bacteria Escherichia coli (minus logarithm of lethal concentration for 50% bacteria pLC50, LC50 in mol/L). The representation of nanoparticles include (i) in the case of the dark cytotoxicity a simplified molecular input-line entry system (SMILES), and (ii) in the case of photo-induced cytotoxicity a SMILES plus symbol '. ^. '. The predictability of the approach is checked up with six random distributions of available data into the visible training and calibration sets, and invisible validation set. The statistical characteristics of these models are correlation coefficient 0.90-0.94 (training set) and 0.73-0.98 (validation set).

Original languageEnglish
Pages (from-to)39-45
Number of pages7
JournalEcotoxicology and Environmental Safety
Volume112
DOIs
Publication statusPublished - Feb 1 2015

Keywords

  • Cytotoxicity
  • Metal oxide nanoparticle
  • Monte Carlo method
  • QSAR
  • Quasi-QSAR, Nano-QSAR
  • Quasi-SMILES

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health
  • Pollution
  • Medicine(all)

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