Abstract
To determine the optimal method of normalizing peak filling rate (PFR) determinations and apply it to the assessment of right ventricular (RV) and left ventricular (LV) filling characteristics and their interactions, 41 subjects with hypertension and 40 matched normals underwent echo-Doppler and nuclear study. Conventional normalization of PFR to end-diastolic volume (EDV) yielded poor correlations between nuclear- and echo-derived PFR (RV, r = 0.34; LV, r = 0.42), whereas nuclear and echo PFR normalized to stroke volume (SV) were closely correlated (RV, r = 0.87; LV, r = 0.92). Further, use of PFR normalized to SV revealed a close relation between RV and LV filling characteristics. Multivariate analysis confirmed that, in contrast to normalization to EDV or early to late filling-velocity ratios ( E A), peak filling rate normalized to SV was independent of ejection fraction and heart rate. In addition, RV filling impairment was related to LV filling impairment, and the effects of hypertension eliminated the independent influence of age on both LV and RV filling. In conclusion, normalization of PFR to SV may be preferable to use of EDV or E A in evaluating RV and LV filling dynamics.
| Original language | English |
|---|---|
| Pages (from-to) | 1074-1082 |
| Number of pages | 9 |
| Journal | American Heart Journal |
| Volume | 130 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1995 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
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Optimal determination of right ventricular filling dynamics in systemic hypertension. / Cittadini, Antonio; Fazio, Serafino; Strömer, Hinrik; Cuocolo, Alberto; Sabatini, Domenico; Imbriaco, Massimo; Saccá, Luigi; Douglas, Pamela S.
In: American Heart Journal, Vol. 130, No. 5, 1995, p. 1074-1082.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Optimal determination of right ventricular filling dynamics in systemic hypertension
AU - Cittadini, Antonio
AU - Fazio, Serafino
AU - Strömer, Hinrik
AU - Cuocolo, Alberto
AU - Sabatini, Domenico
AU - Imbriaco, Massimo
AU - Saccá, Luigi
AU - Douglas, Pamela S.
PY - 1995
Y1 - 1995
N2 - To determine the optimal method of normalizing peak filling rate (PFR) determinations and apply it to the assessment of right ventricular (RV) and left ventricular (LV) filling characteristics and their interactions, 41 subjects with hypertension and 40 matched normals underwent echo-Doppler and nuclear study. Conventional normalization of PFR to end-diastolic volume (EDV) yielded poor correlations between nuclear- and echo-derived PFR (RV, r = 0.34; LV, r = 0.42), whereas nuclear and echo PFR normalized to stroke volume (SV) were closely correlated (RV, r = 0.87; LV, r = 0.92). Further, use of PFR normalized to SV revealed a close relation between RV and LV filling characteristics. Multivariate analysis confirmed that, in contrast to normalization to EDV or early to late filling-velocity ratios ( E A), peak filling rate normalized to SV was independent of ejection fraction and heart rate. In addition, RV filling impairment was related to LV filling impairment, and the effects of hypertension eliminated the independent influence of age on both LV and RV filling. In conclusion, normalization of PFR to SV may be preferable to use of EDV or E A in evaluating RV and LV filling dynamics.
AB - To determine the optimal method of normalizing peak filling rate (PFR) determinations and apply it to the assessment of right ventricular (RV) and left ventricular (LV) filling characteristics and their interactions, 41 subjects with hypertension and 40 matched normals underwent echo-Doppler and nuclear study. Conventional normalization of PFR to end-diastolic volume (EDV) yielded poor correlations between nuclear- and echo-derived PFR (RV, r = 0.34; LV, r = 0.42), whereas nuclear and echo PFR normalized to stroke volume (SV) were closely correlated (RV, r = 0.87; LV, r = 0.92). Further, use of PFR normalized to SV revealed a close relation between RV and LV filling characteristics. Multivariate analysis confirmed that, in contrast to normalization to EDV or early to late filling-velocity ratios ( E A), peak filling rate normalized to SV was independent of ejection fraction and heart rate. In addition, RV filling impairment was related to LV filling impairment, and the effects of hypertension eliminated the independent influence of age on both LV and RV filling. In conclusion, normalization of PFR to SV may be preferable to use of EDV or E A in evaluating RV and LV filling dynamics.
UR - http://www.scopus.com/inward/record.url?scp=0028805180&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028805180&partnerID=8YFLogxK
U2 - 10.1016/0002-8703(95)90211-2
DO - 10.1016/0002-8703(95)90211-2
M3 - Article
C2 - 7484739
AN - SCOPUS:0028805180
VL - 130
SP - 1074
EP - 1082
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 5
ER -