Optimal determination of right ventricular filling dynamics in systemic hypertension

Antonio Cittadini, Serafino Fazio, Hinrik Strömer, Alberto Cuocolo, Domenico Sabatini, Massimo Imbriaco, Luigi Saccá, Pamela S. Douglas

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

To determine the optimal method of normalizing peak filling rate (PFR) determinations and apply it to the assessment of right ventricular (RV) and left ventricular (LV) filling characteristics and their interactions, 41 subjects with hypertension and 40 matched normals underwent echo-Doppler and nuclear study. Conventional normalization of PFR to end-diastolic volume (EDV) yielded poor correlations between nuclear- and echo-derived PFR (RV, r = 0.34; LV, r = 0.42), whereas nuclear and echo PFR normalized to stroke volume (SV) were closely correlated (RV, r = 0.87; LV, r = 0.92). Further, use of PFR normalized to SV revealed a close relation between RV and LV filling characteristics. Multivariate analysis confirmed that, in contrast to normalization to EDV or early to late filling-velocity ratios ( E A), peak filling rate normalized to SV was independent of ejection fraction and heart rate. In addition, RV filling impairment was related to LV filling impairment, and the effects of hypertension eliminated the independent influence of age on both LV and RV filling. In conclusion, normalization of PFR to SV may be preferable to use of EDV or E A in evaluating RV and LV filling dynamics.

Original languageEnglish
Pages (from-to)1074-1082
Number of pages9
JournalAmerican Heart Journal
Volume130
Issue number5
DOIs
Publication statusPublished - 1995

Fingerprint

Stroke Volume
Hypertension
Multivariate Analysis
Heart Rate

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Cittadini, A., Fazio, S., Strömer, H., Cuocolo, A., Sabatini, D., Imbriaco, M., ... Douglas, P. S. (1995). Optimal determination of right ventricular filling dynamics in systemic hypertension. American Heart Journal, 130(5), 1074-1082. https://doi.org/10.1016/0002-8703(95)90211-2

Optimal determination of right ventricular filling dynamics in systemic hypertension. / Cittadini, Antonio; Fazio, Serafino; Strömer, Hinrik; Cuocolo, Alberto; Sabatini, Domenico; Imbriaco, Massimo; Saccá, Luigi; Douglas, Pamela S.

In: American Heart Journal, Vol. 130, No. 5, 1995, p. 1074-1082.

Research output: Contribution to journalArticle

Cittadini, A, Fazio, S, Strömer, H, Cuocolo, A, Sabatini, D, Imbriaco, M, Saccá, L & Douglas, PS 1995, 'Optimal determination of right ventricular filling dynamics in systemic hypertension', American Heart Journal, vol. 130, no. 5, pp. 1074-1082. https://doi.org/10.1016/0002-8703(95)90211-2
Cittadini A, Fazio S, Strömer H, Cuocolo A, Sabatini D, Imbriaco M et al. Optimal determination of right ventricular filling dynamics in systemic hypertension. American Heart Journal. 1995;130(5):1074-1082. https://doi.org/10.1016/0002-8703(95)90211-2
Cittadini, Antonio ; Fazio, Serafino ; Strömer, Hinrik ; Cuocolo, Alberto ; Sabatini, Domenico ; Imbriaco, Massimo ; Saccá, Luigi ; Douglas, Pamela S. / Optimal determination of right ventricular filling dynamics in systemic hypertension. In: American Heart Journal. 1995 ; Vol. 130, No. 5. pp. 1074-1082.
@article{41c26d0a3d064b56a293688acd0293b8,
title = "Optimal determination of right ventricular filling dynamics in systemic hypertension",
abstract = "To determine the optimal method of normalizing peak filling rate (PFR) determinations and apply it to the assessment of right ventricular (RV) and left ventricular (LV) filling characteristics and their interactions, 41 subjects with hypertension and 40 matched normals underwent echo-Doppler and nuclear study. Conventional normalization of PFR to end-diastolic volume (EDV) yielded poor correlations between nuclear- and echo-derived PFR (RV, r = 0.34; LV, r = 0.42), whereas nuclear and echo PFR normalized to stroke volume (SV) were closely correlated (RV, r = 0.87; LV, r = 0.92). Further, use of PFR normalized to SV revealed a close relation between RV and LV filling characteristics. Multivariate analysis confirmed that, in contrast to normalization to EDV or early to late filling-velocity ratios ( E A), peak filling rate normalized to SV was independent of ejection fraction and heart rate. In addition, RV filling impairment was related to LV filling impairment, and the effects of hypertension eliminated the independent influence of age on both LV and RV filling. In conclusion, normalization of PFR to SV may be preferable to use of EDV or E A in evaluating RV and LV filling dynamics.",
author = "Antonio Cittadini and Serafino Fazio and Hinrik Str{\"o}mer and Alberto Cuocolo and Domenico Sabatini and Massimo Imbriaco and Luigi Sacc{\'a} and Douglas, {Pamela S.}",
year = "1995",
doi = "10.1016/0002-8703(95)90211-2",
language = "English",
volume = "130",
pages = "1074--1082",
journal = "American Heart Journal",
issn = "0002-8703",
publisher = "Mosby Inc.",
number = "5",

}

TY - JOUR

T1 - Optimal determination of right ventricular filling dynamics in systemic hypertension

AU - Cittadini, Antonio

AU - Fazio, Serafino

AU - Strömer, Hinrik

AU - Cuocolo, Alberto

AU - Sabatini, Domenico

AU - Imbriaco, Massimo

AU - Saccá, Luigi

AU - Douglas, Pamela S.

PY - 1995

Y1 - 1995

N2 - To determine the optimal method of normalizing peak filling rate (PFR) determinations and apply it to the assessment of right ventricular (RV) and left ventricular (LV) filling characteristics and their interactions, 41 subjects with hypertension and 40 matched normals underwent echo-Doppler and nuclear study. Conventional normalization of PFR to end-diastolic volume (EDV) yielded poor correlations between nuclear- and echo-derived PFR (RV, r = 0.34; LV, r = 0.42), whereas nuclear and echo PFR normalized to stroke volume (SV) were closely correlated (RV, r = 0.87; LV, r = 0.92). Further, use of PFR normalized to SV revealed a close relation between RV and LV filling characteristics. Multivariate analysis confirmed that, in contrast to normalization to EDV or early to late filling-velocity ratios ( E A), peak filling rate normalized to SV was independent of ejection fraction and heart rate. In addition, RV filling impairment was related to LV filling impairment, and the effects of hypertension eliminated the independent influence of age on both LV and RV filling. In conclusion, normalization of PFR to SV may be preferable to use of EDV or E A in evaluating RV and LV filling dynamics.

AB - To determine the optimal method of normalizing peak filling rate (PFR) determinations and apply it to the assessment of right ventricular (RV) and left ventricular (LV) filling characteristics and their interactions, 41 subjects with hypertension and 40 matched normals underwent echo-Doppler and nuclear study. Conventional normalization of PFR to end-diastolic volume (EDV) yielded poor correlations between nuclear- and echo-derived PFR (RV, r = 0.34; LV, r = 0.42), whereas nuclear and echo PFR normalized to stroke volume (SV) were closely correlated (RV, r = 0.87; LV, r = 0.92). Further, use of PFR normalized to SV revealed a close relation between RV and LV filling characteristics. Multivariate analysis confirmed that, in contrast to normalization to EDV or early to late filling-velocity ratios ( E A), peak filling rate normalized to SV was independent of ejection fraction and heart rate. In addition, RV filling impairment was related to LV filling impairment, and the effects of hypertension eliminated the independent influence of age on both LV and RV filling. In conclusion, normalization of PFR to SV may be preferable to use of EDV or E A in evaluating RV and LV filling dynamics.

UR - http://www.scopus.com/inward/record.url?scp=0028805180&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028805180&partnerID=8YFLogxK

U2 - 10.1016/0002-8703(95)90211-2

DO - 10.1016/0002-8703(95)90211-2

M3 - Article

C2 - 7484739

AN - SCOPUS:0028805180

VL - 130

SP - 1074

EP - 1082

JO - American Heart Journal

JF - American Heart Journal

SN - 0002-8703

IS - 5

ER -