Optimal dietary calcium intake in HIV treated patients: No femoral osteoporosis but higher cardiovascular risk

Laura Galli, Alessandro Rubinacci, Deborah Cocorullo, Stefania Salpietro, Vincenzo Spagnuolo, Nicola Gianotti, Alba Bigoloni, Concetta Vinci, Giovanna Mignogna, Marcella Sirtori, Adriano Lazzarin, Antonella Castagna

Research output: Contribution to journalArticlepeer-review


Background and aims: We performed a cross-sectional study on adult HIV-infected patients, on HAART, without calcium or vitamin D supplementation to evaluate if the cardiovascular risk or the presence of osteoporosis may be predictive factors of an optimal daily calcium intake (DCI>1000 mg/day). Methods: Patients underwent a dual-energy X-ray absorptiometry, measured biochemical parameters and compiled a validated questionnaire for the assessment of DCI. Osteoporosis (OP) was defined according to the WHO classification at either the vertebral spine or femoral neck. Cardiovascular risk was assessed by the 10-year Framingham cardiovascular risk score. Results: 200 HIV-infected patients evaluated: 171 (86%) males with a median age of 48.1 (42.3-53.8) years and 10.6 (4.3-13.6) years of HAART exposure. DCI was 889 (589-1308) mg/day and 79 (40%) patients had an optimal DCI. Framingham risk>20% was found in 13 (6.7%) patients and femoral OP was diagnosed in 12 (6%) pts.By multivariate analysis, optimal DCI was more likely in patients with a Framingham risk>20% [OR = 5.547, 95% CI:1.337, p = 0.025] and less likely in patients with femoral osteoporosis [OR = 0.159, 95% CI: 0.018-0.790, p = 0.047]. Conclusions: We found that an optimal dietary calcium intake was more likely in patients with high cardiovascular risk and no femoral osteoporosis.

Original languageEnglish
Pages (from-to)363-366
Number of pages4
JournalClinical Nutrition
Issue number2
Publication statusPublished - 2014


  • Cardiovascular risk
  • Dietary calcium intake
  • HIV-infected patients
  • Osteoporosis

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Nutrition and Dietetics

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