Optimal positioning of optodes on the scalp for personalized functional near-infrared spectroscopy investigations

A. Machado, Z. Cai, G. Pellegrino, O. Marcotte, T. Vincent, J. M. Lina, E. Kobayashi, C. Grova

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Application of functional Near InfraRed Spectroscopy (fNIRS) in neurology is still limited as a good optical coupling and optimized optode coverage of specific brain regions remains challenging, notably for prolonged monitoring. Methods: We propose to evaluate a new procedure allowing accurate investigation of specific brain regions. The procedure consists in: (i) A priori maximization of spatial sensitivity of fNIRS measurements targeting specific brain regions, while reducing the number of applied optodes in order to decrease installation time and improve subject comfort. (ii) Utilization of a 3D neuronavigation device and usage of collodion to glue optodes on the scalp, ensuring good optical contact for prolonged investigations. (iii) Local reconstruction of the hemodynamic activity along the cortical surface using inverse modelling. Results: Using realistic simulations, we demonstrated that maps derived from optimal montage acquisitions showed, after reconstruction, spatial resolution only slightly lower to that of ultra high density montages while significantly reducing the number of optodes. The optimal montages provided overall good quantitative accuracy especially at the peak of the spatially reconstructed map. We also evaluated real motor responses in two healthy subjects and obtained reproducible motor responses over different sessions. Comparison with existing methods: We are among the first to propose a mathematical optimization strategy, allowing high sensitivity measurements. Conclusions: Our results support that using personalized optimal montages should allow to conduct accurate fNIRS studies in clinical settings and realistic lifestyle conditions.

Original languageEnglish
Pages (from-to)91-108
Number of pages18
JournalJournal of Neuroscience Methods
Volume309
DOIs
Publication statusPublished - Nov 1 2018

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Near-Infrared Spectroscopy
Scalp
Brain
Neuronavigation
Collodion
Neurology
Adhesives
Life Style
Healthy Volunteers
Hemodynamics
Equipment and Supplies

Keywords

  • Diffuse optical tomography
  • Functional Near InfraRed Spectroscopy
  • Inverse problem
  • Optimization
  • Personalized optode montages

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Optimal positioning of optodes on the scalp for personalized functional near-infrared spectroscopy investigations. / Machado, A.; Cai, Z.; Pellegrino, G.; Marcotte, O.; Vincent, T.; Lina, J. M.; Kobayashi, E.; Grova, C.

In: Journal of Neuroscience Methods, Vol. 309, 01.11.2018, p. 91-108.

Research output: Contribution to journalArticle

Machado, A. ; Cai, Z. ; Pellegrino, G. ; Marcotte, O. ; Vincent, T. ; Lina, J. M. ; Kobayashi, E. ; Grova, C. / Optimal positioning of optodes on the scalp for personalized functional near-infrared spectroscopy investigations. In: Journal of Neuroscience Methods. 2018 ; Vol. 309. pp. 91-108.
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