Optimal Predictive Low Glucose Management (PLGM) settings during physical exercise in adolescents with type 1 diabetes

Valentino Cherubini, Rosaria Gesuita, Edlira Skrami, Ivana Rabbone, Riccardo Bonfanti, Claudia Arnaldi, Giuseppe D'Annunzio, Annapaola Frongia, Fortunato Lombardo, Elvira Piccinno, Riccardo Schiaffini, Sonia Toni, Stefano Tumini, Davide Tinti, Paola Cipriano, Nicola Minuto, Lorenzo Lenzi, Lucia Ferrito, Claudia Ventrici, Federica OrtolaniOhad Cohen, Andrea Scaramuzza

Research output: Contribution to journalArticlepeer-review


OBJECTIVES: To assess the optimal setting of the predictive low glucose management (PLGM) algorithm for preventing exercise-induced hypoglycemia in adolescents with type 1 diabetes.

METHODS: Thirty-four adolescents, 15-20 y, wearing PLGM system, were followed during 3 days exercise during a diabetes camp. PLGM threshold was set at 70 mg/dl between 8 am-10 pm and 90 mg/dl during 10 pm-8 am. Adolescents were divided in group A and B, with PLGM threshold at 90 and 70 mg/dl, respectively during exercise. Time spent in hypoglycemia and AUC for time slots 8 am-1 pm,1 pm-4 pm, 4 pm-11 pm, 11 pm-3 am, 3 am-8 am, in 3 days were compared between groups by Wilcoxon rank sum test.

RESULTS: We analyzed 31 patients (median age 15.0 y, 58.1% males, median diabetes duration 7.0 y, HbA1c 7.1%). No significant difference has been observed in time spent in hypoglycemia between groups using threshold 70 or 90. Time spent in target was similar in both groups, as well as time spent in hypo or hyperglycemia. The trends of blood glucose over the three days in the 2 groups over-lapped without significant differences.

CONCLUSIONS: A PLGM threshold of 90 mg/dl during the night was associated with reduced time in hypoglycemia in adolescents doing frequent physical exercise, while maintaining 65.1% time in range during the day. However, a threshold of 70 mg/dl seems to be safe in the duration of the physical exercise. PLGM system in adolescents with type 1 diabetes was effective to prevent hypoglycemia during and after exercise, irrespective of the PLGM thresholds used. This article is protected by copyright. All rights reserved.

Original languageEnglish
JournalPediatric Diabetes
Publication statusE-pub ahead of print - Oct 31 2018


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