Optimal use of maraviroc in clinical practice

Vincent Soriano, Anna María Geretti, Carlo Federico Perno, Gerd Fätkenheuer, Deenan Pillay, Jacques Reynes, Giuseppe Tambussi, Vincent Calvez, José Alcamí, Juergen Rockstroh

Research output: Contribution to journalArticle

Abstract

Maraviroc belongs to a new class of anti-HIV drugs named CCR5 antagonists, which block HIV entry into cells. It has proven potent efficacy in treatment-experienced patients with multiple drug failure. Its favourable toxicity profile makes the drug attractive for consideration in other clinical scenarios, including patients with earlier stages of disease, cardiovascular risk and viral hepatitis coinfection. Because of its unique mechanism of action-blocking viral entry, studies in patients with primary HIV infection and in the context of preexposure and postexposure prophylaxis are particularly warranted. However, given its exclusive activity against CCR5 tropic strains, viral tropism testing is mandatory before using CCR5 antagonists in the clinic. Efforts to improve the reliability of viral tropism assessment using genotypic tests are underway, and it is likely that these tools will soon replace phenotypic assays, which are more expensive, difficult to perform and take a long time.

Original languageEnglish
Pages (from-to)2231-2240
Number of pages10
JournalAIDS (London, England)
Volume22
Issue number17
DOIs
Publication statusPublished - 2008

Keywords

  • Chemokine (C-C motif) receptor 5 antagonists
  • HIV
  • Maraviroc
  • Tropism

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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  • Cite this

    Soriano, V., Geretti, A. M., Perno, C. F., Fätkenheuer, G., Pillay, D., Reynes, J., Tambussi, G., Calvez, V., Alcamí, J., & Rockstroh, J. (2008). Optimal use of maraviroc in clinical practice. AIDS (London, England), 22(17), 2231-2240. https://doi.org/10.1097/QAD.0b013e3283136d95