Optimization of flow reserve measurement using SPECT technology to evaluate the determinants of coronary microvascular dysfunction in diabetes

Cecilia Marini, Gianpaolo Bezante, Patrizia Gandolfo, Elisa Modonesi, Silvia D. Morbelli, Angelo Depascale, Daniela Rollando, Davide Maggi, Manuela Albertelli, Riccardo Armonino, Manrico Balbi, Claudio Brunelli, Renzo Cordera, Gianmario Sambuceti

Research output: Contribution to journalArticle

Abstract

Purpose: The aim of this study was to validate a new method to measure regional myocardial perfusion reserve (MPR) with technetium-labelled tracers in patients with type 2 diabetes mellitus (DM2). Methods: A total of 40 consecutive DM2 patients without history of coronary artery disease (CAD) and 7 control subjects were recruited. Dipyridamole myocardial blood flow index (MBF) was assessed by measuring first transit counts in the pulmonary artery and myocardial count rate from gated SPECT images using 99mTc-labelled tracers. The corresponding MBF index was estimated 2 h later according to the same procedure. Regional myocardial perfusion reserve (MPR) was defined as the ratio between dipyridamole and baseline MBF using a 17-segment left ventricular (LV) model. Coronary flow reserve (CFR) was estimated by transthoracic contrast echo Doppler monitoring of flow velocity in the left anterior descending coronary artery (LAD) during the same session. Results: Estimated MPR was higher in control subjects than in patients (3.36±0.66 vs 1.91±0.61, respectively, p

Original languageEnglish
Pages (from-to)357-367
Number of pages11
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume37
Issue number2
DOIs
Publication statusPublished - Feb 2010

Keywords

  • Gated SPECT
  • Myocardial perfusion reserve
  • Transthoracic contrast echo Doppler
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Marini, C., Bezante, G., Gandolfo, P., Modonesi, E., Morbelli, S. D., Depascale, A., Rollando, D., Maggi, D., Albertelli, M., Armonino, R., Balbi, M., Brunelli, C., Cordera, R., & Sambuceti, G. (2010). Optimization of flow reserve measurement using SPECT technology to evaluate the determinants of coronary microvascular dysfunction in diabetes. European Journal of Nuclear Medicine and Molecular Imaging, 37(2), 357-367. https://doi.org/10.1007/s00259-009-1316-5