Optimization of intensity modulated radiation therapy

Assessing the complexity of the problem

S. Marzi, M. Mattia, P. Del Giudice, B. Caccia, M. Benassi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Intensity modulated radiation therapy (IMRT) is one of the most innovative techniques in oncological radiotherapy, allowing to conform the dose delivery to the tumoral target, preserving the normal tissue. The high number of parameters involved in the IMRT treatment planning requires an automated approach to the beam modulation. Such optimization process consists in the search of the global minimum of a cost function representing a quality index for the treatment. The complexity of this task, has been analyzed with a statistical approach for three clinical cases of particular interest in IMRT. Our main result is that a cost function based on dose-volume constraints entails lower complexity of the optimization process, in terms of the choice of the parameters defining the cost function and in a smaller sensitivity to the initial conditions for the optimization algorithm.

Original languageEnglish
Pages (from-to)225-230
Number of pages6
JournalAnnali dell'Istituto Superiore di Sanita
Volume37
Issue number2
Publication statusPublished - 2001

Fingerprint

Radiotherapy
Costs and Cost Analysis
Therapeutics

Keywords

  • IMRT
  • Inverse problem
  • Optimization
  • Radiotherapy

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Optimization of intensity modulated radiation therapy : Assessing the complexity of the problem. / Marzi, S.; Mattia, M.; Del Giudice, P.; Caccia, B.; Benassi, M.

In: Annali dell'Istituto Superiore di Sanita, Vol. 37, No. 2, 2001, p. 225-230.

Research output: Contribution to journalArticle

Marzi, S. ; Mattia, M. ; Del Giudice, P. ; Caccia, B. ; Benassi, M. / Optimization of intensity modulated radiation therapy : Assessing the complexity of the problem. In: Annali dell'Istituto Superiore di Sanita. 2001 ; Vol. 37, No. 2. pp. 225-230.
@article{5be0a67c01de4d9d8a6592531ad6b43f,
title = "Optimization of intensity modulated radiation therapy: Assessing the complexity of the problem",
abstract = "Intensity modulated radiation therapy (IMRT) is one of the most innovative techniques in oncological radiotherapy, allowing to conform the dose delivery to the tumoral target, preserving the normal tissue. The high number of parameters involved in the IMRT treatment planning requires an automated approach to the beam modulation. Such optimization process consists in the search of the global minimum of a cost function representing a quality index for the treatment. The complexity of this task, has been analyzed with a statistical approach for three clinical cases of particular interest in IMRT. Our main result is that a cost function based on dose-volume constraints entails lower complexity of the optimization process, in terms of the choice of the parameters defining the cost function and in a smaller sensitivity to the initial conditions for the optimization algorithm.",
keywords = "IMRT, Inverse problem, Optimization, Radiotherapy",
author = "S. Marzi and M. Mattia and {Del Giudice}, P. and B. Caccia and M. Benassi",
year = "2001",
language = "English",
volume = "37",
pages = "225--230",
journal = "Annali dell'Istituto Superiore di Sanita",
issn = "0021-2571",
publisher = "Istituto Superiore di Sanita",
number = "2",

}

TY - JOUR

T1 - Optimization of intensity modulated radiation therapy

T2 - Assessing the complexity of the problem

AU - Marzi, S.

AU - Mattia, M.

AU - Del Giudice, P.

AU - Caccia, B.

AU - Benassi, M.

PY - 2001

Y1 - 2001

N2 - Intensity modulated radiation therapy (IMRT) is one of the most innovative techniques in oncological radiotherapy, allowing to conform the dose delivery to the tumoral target, preserving the normal tissue. The high number of parameters involved in the IMRT treatment planning requires an automated approach to the beam modulation. Such optimization process consists in the search of the global minimum of a cost function representing a quality index for the treatment. The complexity of this task, has been analyzed with a statistical approach for three clinical cases of particular interest in IMRT. Our main result is that a cost function based on dose-volume constraints entails lower complexity of the optimization process, in terms of the choice of the parameters defining the cost function and in a smaller sensitivity to the initial conditions for the optimization algorithm.

AB - Intensity modulated radiation therapy (IMRT) is one of the most innovative techniques in oncological radiotherapy, allowing to conform the dose delivery to the tumoral target, preserving the normal tissue. The high number of parameters involved in the IMRT treatment planning requires an automated approach to the beam modulation. Such optimization process consists in the search of the global minimum of a cost function representing a quality index for the treatment. The complexity of this task, has been analyzed with a statistical approach for three clinical cases of particular interest in IMRT. Our main result is that a cost function based on dose-volume constraints entails lower complexity of the optimization process, in terms of the choice of the parameters defining the cost function and in a smaller sensitivity to the initial conditions for the optimization algorithm.

KW - IMRT

KW - Inverse problem

KW - Optimization

KW - Radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=0035149162&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035149162&partnerID=8YFLogxK

M3 - Article

VL - 37

SP - 225

EP - 230

JO - Annali dell'Istituto Superiore di Sanita

JF - Annali dell'Istituto Superiore di Sanita

SN - 0021-2571

IS - 2

ER -