Optimization of intensity modulated radiation therapy: Assessing the complexity of the problem

S. Marzi, M. Mattia, P. Del Giudice, B. Caccia, M. Benassi

Research output: Contribution to journalArticlepeer-review


Intensity modulated radiation therapy (IMRT) is one of the most innovative techniques in oncological radiotherapy, allowing to conform the dose delivery to the tumoral target, preserving the normal tissue. The high number of parameters involved in the IMRT treatment planning requires an automated approach to the beam modulation. Such optimization process consists in the search of the global minimum of a cost function representing a quality index for the treatment. The complexity of this task, has been analyzed with a statistical approach for three clinical cases of particular interest in IMRT. Our main result is that a cost function based on dose-volume constraints entails lower complexity of the optimization process, in terms of the choice of the parameters defining the cost function and in a smaller sensitivity to the initial conditions for the optimization algorithm.

Original languageEnglish
Pages (from-to)225-230
Number of pages6
JournalAnnali dell'Istituto Superiore di Sanita
Issue number2
Publication statusPublished - 2001


  • IMRT
  • Inverse problem
  • Optimization
  • Radiotherapy

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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