Optimization of pyrazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)

Tram Huynh, Zhong Chen, Suhong Pang, Jieping Geng, Tiziano Bandiera, Simona Bindi, Paola Vianello, Fulvia Roletto, Sandrine Thieffine, Arturo Galvani, Wayne Vaccaro, Michael A. Poss, George L. Trainor, Matthew V. Lorenzi, Marco Gottardis, Lata Jayaraman, Ashok V. Purandare

Research output: Contribution to journalArticlepeer-review

Abstract

Design, synthesis, and SAR development led to the identification of the potent, novel, and selective pyrazole based inhibitor (7f) of Coactivator Associated Arginine Methyltransferase (CARM1).

Original languageEnglish
Pages (from-to)2924-2927
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number11
DOIs
Publication statusPublished - Jun 1 2009

Keywords

  • CARM1
  • Coactivator associated arginine methyltransferase 1
  • Methyltransferase
  • PRMT4
  • Pyrazole

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

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