Optimization of tracer injection for 3D18F-FDG whole body (WB) PET studies using an acquisition-specific NEC (AS-NEC) curve generation

M. Danna; M. Lecchi; V. Bettinardi; M. C. Gilardi; C. W. Stearns; G. Lucignani; F. Fazio

Optimization of tracer injection for 3D18F-FDG whole body (WB) PET studies using an acquisition-specific NEC (AS-NEC) curve generation

M. Danna, M. Lecchi, V. Bettinardi, M. C. Gilardi, C. W. Stearns, G. Lucignani, F. Fazio

IRCCS Ospedale San Raffaele

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Aim of this work was the implementation and validation, for the Discovery-ST PET/CT (GE Medical Systems) system, of the acquisition specific noise equivalent counts (AS-NEC) method to establish the amount of the tracer to be injected in 3D ¹⁸F-FDG whole body (WB) studies to achieve the peak of the NEC (NEC-p) at the acquisition time. The AS-NEC model uses prompts, delayed events and system deadtime of a reference acquisition, to calculate the full shape of the NEC curve. The method was implemented using a 3D decay series of the NEMA-01 (line source in a Teflon 20×70cm cylinder) phantom and validated with the NEMA-94 (20×20cm uniform cylinder) and NEMA-01 image quality phantoms. The AS-NEC curves generated by single frames of the phantom series well correlated with the experimental NEC curves proving the validity and the generality of the method. The AS-NEC model was then retrospectively applied on 40 3D ¹⁸F-FDG WB studies in a range of body mass index (BMI) between 16 and 31 kg/m² (6 under-weight (uw), 18 normal-weight (nw), 16 over-weight (ow)). For each frame acquisition of each patient study, the activity at the acquisition time, corresponding to the NEC-p was identified on me AS-NEC curves. Furthermore, as the NEC curves show a large region around the NEC-p with small variations (nearly plateau), the values of radioactivity corresponding to reduction of 1%, 3% and 5% with respect to NEC-p were also considered as possible alternative dose to be injected in the patients. The results show that the average activity corresponding to the NEC-p was comparable for the three BMI classes: 336.7MBq (sd=22.2), 329.3MBq (sd=33.3), 344.1MBq (sd=48.1) for uw, nw and ow respectively. The average NEC-p activity for all patients was 336.7MBq (sd=40.7). The mean values of the radioactivity at 1%, 3% and 5% with respect to the NEC-p were: 284.9MBq (sd=40.7), 247.9MBq (sd=33.3) and 225.7MBq (sd=29.6) respectively. These results indicate the possibility to use, with the Discovery ST, a single injection protocol of 444MBq (for the range of BMI considered) to have an activity at the acquisition time (after 45 min of uptake) of 337MBq, to reach the NEC-p. Nevertheless, the plateau near the NEC-p suggests the possibility to reduce the dose to be injected in clinical studies at 329MBq while preserving suitable NEC performance (-3%) with respect to the NEC-p.

Original language	English
Title of host publication	IEEE Nuclear Science Symposium Conference Record
Editors	J.A. Seibert
Pages	2615-2619
Number of pages	5
Volume	4
Publication status	Published - 2004
Event	2004 Nuclear Science Symposium, Medical Imaging Conference, Symposium on Nuclear Power Systems and the 14th International Workshop on Room Temperature Semiconductor X- and Gamma- Ray Detectors - Rome, Italy Duration: Oct 16 2004 → Oct 22 2004

Other

Other	2004 Nuclear Science Symposium, Medical Imaging Conference, Symposium on Nuclear Power Systems and the 14th International Workshop on Room Temperature Semiconductor X- and Gamma- Ray Detectors
Country	Italy
City	Rome
Period	10/16/04 → 10/22/04

ASJC Scopus subject areas

Computer Vision and Pattern Recognition
Industrial and Manufacturing Engineering

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Danna, M., Lecchi, M., Bettinardi, V., Gilardi, M. C., Stearns, C. W., Lucignani, G., & Fazio, F. (2004). Optimization of tracer injection for 3D18F-FDG whole body (WB) PET studies using an acquisition-specific NEC (AS-NEC) curve generation. In J. A. Seibert (Ed.), IEEE Nuclear Science Symposium Conference Record (Vol. 4, pp. 2615-2619)

Optimization of tracer injection for 3D18F-FDG whole body (WB) PET studies using an acquisition-specific NEC (AS-NEC) curve generation. / Danna, M.; Lecchi, M.; Bettinardi, V.; Gilardi, M. C.; Stearns, C. W.; Lucignani, G.; Fazio, F.

IEEE Nuclear Science Symposium Conference Record. ed. / J.A. Seibert. Vol. 4 2004. p. 2615-2619.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Danna, M, Lecchi, M, Bettinardi, V, Gilardi, MC, Stearns, CW, Lucignani, G & Fazio, F 2004, Optimization of tracer injection for 3D18F-FDG whole body (WB) PET studies using an acquisition-specific NEC (AS-NEC) curve generation. in JA Seibert (ed.), IEEE Nuclear Science Symposium Conference Record. vol. 4, pp. 2615-2619, 2004 Nuclear Science Symposium, Medical Imaging Conference, Symposium on Nuclear Power Systems and the 14th International Workshop on Room Temperature Semiconductor X- and Gamma- Ray Detectors, Rome, Italy, 10/16/04.

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title = "Optimization of tracer injection for 3D18F-FDG whole body (WB) PET studies using an acquisition-specific NEC (AS-NEC) curve generation",

abstract = "Aim of this work was the implementation and validation, for the Discovery-ST PET/CT (GE Medical Systems) system, of the acquisition specific noise equivalent counts (AS-NEC) method to establish the amount of the tracer to be injected in 3D 18F-FDG whole body (WB) studies to achieve the peak of the NEC (NEC-p) at the acquisition time. The AS-NEC model uses prompts, delayed events and system deadtime of a reference acquisition, to calculate the full shape of the NEC curve. The method was implemented using a 3D decay series of the NEMA-01 (line source in a Teflon 20×70cm cylinder) phantom and validated with the NEMA-94 (20×20cm uniform cylinder) and NEMA-01 image quality phantoms. The AS-NEC curves generated by single frames of the phantom series well correlated with the experimental NEC curves proving the validity and the generality of the method. The AS-NEC model was then retrospectively applied on 40 3D 18F-FDG WB studies in a range of body mass index (BMI) between 16 and 31 kg/m2 (6 under-weight (uw), 18 normal-weight (nw), 16 over-weight (ow)). For each frame acquisition of each patient study, the activity at the acquisition time, corresponding to the NEC-p was identified on me AS-NEC curves. Furthermore, as the NEC curves show a large region around the NEC-p with small variations (nearly plateau), the values of radioactivity corresponding to reduction of 1%, 3% and 5% with respect to NEC-p were also considered as possible alternative dose to be injected in the patients. The results show that the average activity corresponding to the NEC-p was comparable for the three BMI classes: 336.7MBq (sd=22.2), 329.3MBq (sd=33.3), 344.1MBq (sd=48.1) for uw, nw and ow respectively. The average NEC-p activity for all patients was 336.7MBq (sd=40.7). The mean values of the radioactivity at 1%, 3% and 5% with respect to the NEC-p were: 284.9MBq (sd=40.7), 247.9MBq (sd=33.3) and 225.7MBq (sd=29.6) respectively. These results indicate the possibility to use, with the Discovery ST, a single injection protocol of 444MBq (for the range of BMI considered) to have an activity at the acquisition time (after 45 min of uptake) of 337MBq, to reach the NEC-p. Nevertheless, the plateau near the NEC-p suggests the possibility to reduce the dose to be injected in clinical studies at 329MBq while preserving suitable NEC performance (-3%) with respect to the NEC-p.",

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volume = "4",

pages = "2615--2619",

editor = "J.A. Seibert",

booktitle = "IEEE Nuclear Science Symposium Conference Record",

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T1 - Optimization of tracer injection for 3D18F-FDG whole body (WB) PET studies using an acquisition-specific NEC (AS-NEC) curve generation

AU - Danna, M.

AU - Lecchi, M.

AU - Bettinardi, V.

AU - Gilardi, M. C.

AU - Stearns, C. W.

AU - Lucignani, G.

AU - Fazio, F.

PY - 2004

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N2 - Aim of this work was the implementation and validation, for the Discovery-ST PET/CT (GE Medical Systems) system, of the acquisition specific noise equivalent counts (AS-NEC) method to establish the amount of the tracer to be injected in 3D 18F-FDG whole body (WB) studies to achieve the peak of the NEC (NEC-p) at the acquisition time. The AS-NEC model uses prompts, delayed events and system deadtime of a reference acquisition, to calculate the full shape of the NEC curve. The method was implemented using a 3D decay series of the NEMA-01 (line source in a Teflon 20×70cm cylinder) phantom and validated with the NEMA-94 (20×20cm uniform cylinder) and NEMA-01 image quality phantoms. The AS-NEC curves generated by single frames of the phantom series well correlated with the experimental NEC curves proving the validity and the generality of the method. The AS-NEC model was then retrospectively applied on 40 3D 18F-FDG WB studies in a range of body mass index (BMI) between 16 and 31 kg/m2 (6 under-weight (uw), 18 normal-weight (nw), 16 over-weight (ow)). For each frame acquisition of each patient study, the activity at the acquisition time, corresponding to the NEC-p was identified on me AS-NEC curves. Furthermore, as the NEC curves show a large region around the NEC-p with small variations (nearly plateau), the values of radioactivity corresponding to reduction of 1%, 3% and 5% with respect to NEC-p were also considered as possible alternative dose to be injected in the patients. The results show that the average activity corresponding to the NEC-p was comparable for the three BMI classes: 336.7MBq (sd=22.2), 329.3MBq (sd=33.3), 344.1MBq (sd=48.1) for uw, nw and ow respectively. The average NEC-p activity for all patients was 336.7MBq (sd=40.7). The mean values of the radioactivity at 1%, 3% and 5% with respect to the NEC-p were: 284.9MBq (sd=40.7), 247.9MBq (sd=33.3) and 225.7MBq (sd=29.6) respectively. These results indicate the possibility to use, with the Discovery ST, a single injection protocol of 444MBq (for the range of BMI considered) to have an activity at the acquisition time (after 45 min of uptake) of 337MBq, to reach the NEC-p. Nevertheless, the plateau near the NEC-p suggests the possibility to reduce the dose to be injected in clinical studies at 329MBq while preserving suitable NEC performance (-3%) with respect to the NEC-p.

AB - Aim of this work was the implementation and validation, for the Discovery-ST PET/CT (GE Medical Systems) system, of the acquisition specific noise equivalent counts (AS-NEC) method to establish the amount of the tracer to be injected in 3D 18F-FDG whole body (WB) studies to achieve the peak of the NEC (NEC-p) at the acquisition time. The AS-NEC model uses prompts, delayed events and system deadtime of a reference acquisition, to calculate the full shape of the NEC curve. The method was implemented using a 3D decay series of the NEMA-01 (line source in a Teflon 20×70cm cylinder) phantom and validated with the NEMA-94 (20×20cm uniform cylinder) and NEMA-01 image quality phantoms. The AS-NEC curves generated by single frames of the phantom series well correlated with the experimental NEC curves proving the validity and the generality of the method. The AS-NEC model was then retrospectively applied on 40 3D 18F-FDG WB studies in a range of body mass index (BMI) between 16 and 31 kg/m2 (6 under-weight (uw), 18 normal-weight (nw), 16 over-weight (ow)). For each frame acquisition of each patient study, the activity at the acquisition time, corresponding to the NEC-p was identified on me AS-NEC curves. Furthermore, as the NEC curves show a large region around the NEC-p with small variations (nearly plateau), the values of radioactivity corresponding to reduction of 1%, 3% and 5% with respect to NEC-p were also considered as possible alternative dose to be injected in the patients. The results show that the average activity corresponding to the NEC-p was comparable for the three BMI classes: 336.7MBq (sd=22.2), 329.3MBq (sd=33.3), 344.1MBq (sd=48.1) for uw, nw and ow respectively. The average NEC-p activity for all patients was 336.7MBq (sd=40.7). The mean values of the radioactivity at 1%, 3% and 5% with respect to the NEC-p were: 284.9MBq (sd=40.7), 247.9MBq (sd=33.3) and 225.7MBq (sd=29.6) respectively. These results indicate the possibility to use, with the Discovery ST, a single injection protocol of 444MBq (for the range of BMI considered) to have an activity at the acquisition time (after 45 min of uptake) of 337MBq, to reach the NEC-p. Nevertheless, the plateau near the NEC-p suggests the possibility to reduce the dose to be injected in clinical studies at 329MBq while preserving suitable NEC performance (-3%) with respect to the NEC-p.

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