Optimization of vagal stimulation protocol based on spontaneous breathing rate

Liliane Appratto De Souza, Janaina Barcellos Ferreira, Andressa Silveira De Oliveira Schein, Daniela Ravizzoni Dartora, Adenauer Girardi Casali, Catharina M.Carvalho Scassola, Eleonora Tobaldini, Nicola Montano, Stefano Guzzetti, Alberto Porta, Maria Claudia Irigoyen, Karina Rabello Casali

Research output: Contribution to journalArticle

Abstract

Controlled breathing maneuver is being widely applied for cardiovascular autonomic control evaluation and cardiac vagal activation through reduction of breathing rate (BR). However, this maneuver presented contradictory results depending on the protocol and the chosen BR. These variations may be related to the individual intrinsic profile baseline sympathetic tonus, as described before by others. In this study, we evaluated the effect of controlled breathing maneuver on cardiovascular autonomic control in 26 healthy subjects allocated into two protocols: (1) controlled breathing in three different rates (10, 15, and 20 breaths/min) and (2) controlled breathing in rates normalized by the individual spontaneous breathing rate (SBR) at 100, 80, 70, and 50%. Our results showed autonomic responses favorable to vagal modulation with the lower BR maneuvers. Nevertheless, while this activation was variable using the standard protocol, all participants of the normalized protocol demonstrated an increase of vagal modulation at 80% BR (HFnu 80 = 67.5% vs. 48.2%, p < 0.0001). These results suggest that controlled breathing protocols to induce vagal activation should consider the SBR, being limited to values moderately lower than the baseline.

Original languageEnglish
Article number1341
JournalFrontiers in Physiology
Volume9
Issue numberSEP
DOIs
Publication statusPublished - Sep 26 2018

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Keywords

  • Autonomic nervous system
  • Controlled breathing
  • Heart rate variability
  • Spectral analysis
  • Vagal stimulation

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

De Souza, L. A., Ferreira, J. B., De Oliveira Schein, A. S., Dartora, D. R., Casali, A. G., Scassola, C. M. C., ... Casali, K. R. (2018). Optimization of vagal stimulation protocol based on spontaneous breathing rate. Frontiers in Physiology, 9(SEP), [1341]. https://doi.org/10.3389/fphys.2018.01341

Optimization of vagal stimulation protocol based on spontaneous breathing rate. / De Souza, Liliane Appratto; Ferreira, Janaina Barcellos; De Oliveira Schein, Andressa Silveira; Dartora, Daniela Ravizzoni; Casali, Adenauer Girardi; Scassola, Catharina M.Carvalho; Tobaldini, Eleonora; Montano, Nicola; Guzzetti, Stefano; Porta, Alberto; Irigoyen, Maria Claudia; Casali, Karina Rabello.

In: Frontiers in Physiology, Vol. 9, No. SEP, 1341, 26.09.2018.

Research output: Contribution to journalArticle

De Souza, LA, Ferreira, JB, De Oliveira Schein, AS, Dartora, DR, Casali, AG, Scassola, CMC, Tobaldini, E, Montano, N, Guzzetti, S, Porta, A, Irigoyen, MC & Casali, KR 2018, 'Optimization of vagal stimulation protocol based on spontaneous breathing rate', Frontiers in Physiology, vol. 9, no. SEP, 1341. https://doi.org/10.3389/fphys.2018.01341
De Souza LA, Ferreira JB, De Oliveira Schein AS, Dartora DR, Casali AG, Scassola CMC et al. Optimization of vagal stimulation protocol based on spontaneous breathing rate. Frontiers in Physiology. 2018 Sep 26;9(SEP). 1341. https://doi.org/10.3389/fphys.2018.01341
De Souza, Liliane Appratto ; Ferreira, Janaina Barcellos ; De Oliveira Schein, Andressa Silveira ; Dartora, Daniela Ravizzoni ; Casali, Adenauer Girardi ; Scassola, Catharina M.Carvalho ; Tobaldini, Eleonora ; Montano, Nicola ; Guzzetti, Stefano ; Porta, Alberto ; Irigoyen, Maria Claudia ; Casali, Karina Rabello. / Optimization of vagal stimulation protocol based on spontaneous breathing rate. In: Frontiers in Physiology. 2018 ; Vol. 9, No. SEP.
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