Abstract
Controlled breathing maneuver is being widely applied for cardiovascular autonomic control evaluation and cardiac vagal activation through reduction of breathing rate (BR). However, this maneuver presented contradictory results depending on the protocol and the chosen BR. These variations may be related to the individual intrinsic profile baseline sympathetic tonus, as described before by others. In this study, we evaluated the effect of controlled breathing maneuver on cardiovascular autonomic control in 26 healthy subjects allocated into two protocols: (1) controlled breathing in three different rates (10, 15, and 20 breaths/min) and (2) controlled breathing in rates normalized by the individual spontaneous breathing rate (SBR) at 100, 80, 70, and 50%. Our results showed autonomic responses favorable to vagal modulation with the lower BR maneuvers. Nevertheless, while this activation was variable using the standard protocol, all participants of the normalized protocol demonstrated an increase of vagal modulation at 80% BR (HFnu 80 = 67.5% vs. 48.2%, p < 0.0001). These results suggest that controlled breathing protocols to induce vagal activation should consider the SBR, being limited to values moderately lower than the baseline.
| Original language | English |
|---|---|
| Article number | 1341 |
| Journal | Frontiers in Physiology |
| Volume | 9 |
| Issue number | SEP |
| DOIs | |
| Publication status | Published - Sep 26 2018 |
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Keywords
- Autonomic nervous system
- Controlled breathing
- Heart rate variability
- Spectral analysis
- Vagal stimulation
ASJC Scopus subject areas
- Physiology
- Physiology (medical)
Cite this
Optimization of vagal stimulation protocol based on spontaneous breathing rate. / De Souza, Liliane Appratto; Ferreira, Janaina Barcellos; De Oliveira Schein, Andressa Silveira; Dartora, Daniela Ravizzoni; Casali, Adenauer Girardi; Scassola, Catharina M.Carvalho; Tobaldini, Eleonora; Montano, Nicola; Guzzetti, Stefano; Porta, Alberto; Irigoyen, Maria Claudia; Casali, Karina Rabello.
In: Frontiers in Physiology, Vol. 9, No. SEP, 1341, 26.09.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Optimization of vagal stimulation protocol based on spontaneous breathing rate
AU - De Souza, Liliane Appratto
AU - Ferreira, Janaina Barcellos
AU - De Oliveira Schein, Andressa Silveira
AU - Dartora, Daniela Ravizzoni
AU - Casali, Adenauer Girardi
AU - Scassola, Catharina M.Carvalho
AU - Tobaldini, Eleonora
AU - Montano, Nicola
AU - Guzzetti, Stefano
AU - Porta, Alberto
AU - Irigoyen, Maria Claudia
AU - Casali, Karina Rabello
PY - 2018/9/26
Y1 - 2018/9/26
N2 - Controlled breathing maneuver is being widely applied for cardiovascular autonomic control evaluation and cardiac vagal activation through reduction of breathing rate (BR). However, this maneuver presented contradictory results depending on the protocol and the chosen BR. These variations may be related to the individual intrinsic profile baseline sympathetic tonus, as described before by others. In this study, we evaluated the effect of controlled breathing maneuver on cardiovascular autonomic control in 26 healthy subjects allocated into two protocols: (1) controlled breathing in three different rates (10, 15, and 20 breaths/min) and (2) controlled breathing in rates normalized by the individual spontaneous breathing rate (SBR) at 100, 80, 70, and 50%. Our results showed autonomic responses favorable to vagal modulation with the lower BR maneuvers. Nevertheless, while this activation was variable using the standard protocol, all participants of the normalized protocol demonstrated an increase of vagal modulation at 80% BR (HFnu 80 = 67.5% vs. 48.2%, p < 0.0001). These results suggest that controlled breathing protocols to induce vagal activation should consider the SBR, being limited to values moderately lower than the baseline.
AB - Controlled breathing maneuver is being widely applied for cardiovascular autonomic control evaluation and cardiac vagal activation through reduction of breathing rate (BR). However, this maneuver presented contradictory results depending on the protocol and the chosen BR. These variations may be related to the individual intrinsic profile baseline sympathetic tonus, as described before by others. In this study, we evaluated the effect of controlled breathing maneuver on cardiovascular autonomic control in 26 healthy subjects allocated into two protocols: (1) controlled breathing in three different rates (10, 15, and 20 breaths/min) and (2) controlled breathing in rates normalized by the individual spontaneous breathing rate (SBR) at 100, 80, 70, and 50%. Our results showed autonomic responses favorable to vagal modulation with the lower BR maneuvers. Nevertheless, while this activation was variable using the standard protocol, all participants of the normalized protocol demonstrated an increase of vagal modulation at 80% BR (HFnu 80 = 67.5% vs. 48.2%, p < 0.0001). These results suggest that controlled breathing protocols to induce vagal activation should consider the SBR, being limited to values moderately lower than the baseline.
KW - Autonomic nervous system
KW - Controlled breathing
KW - Heart rate variability
KW - Spectral analysis
KW - Vagal stimulation
UR - http://www.scopus.com/inward/record.url?scp=85055147274&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85055147274&partnerID=8YFLogxK
U2 - 10.3389/fphys.2018.01341
DO - 10.3389/fphys.2018.01341
M3 - Article
AN - SCOPUS:85055147274
VL - 9
JO - Frontiers in Physiology
JF - Frontiers in Physiology
SN - 1664-042X
IS - SEP
M1 - 1341
ER -