Optimizing Cholesterol Treatment in Patients With Muscle Complaints

Robert S. Rosenson, Steven Baker, Maciej Banach, Kenneth M. Borow, Lynne T. Braun, Eric Bruckert, Liam R. Brunham, Alberico L. Catapano, Marshall B. Elam, G. B.John Mancini, Patrick M. Moriarty, Pamela B. Morris, Paul Muntner, Kausik K. Ray, Erik S. Stroes, Beth A. Taylor, Valerie H. Taylor, Gerald F. Watts, Paul D. Thompson

Research output: Contribution to journalReview articlepeer-review


Statins are highly effective for preventing cardiovascular events by reducing low-density lipoprotein cholesterol (LDL-C). However, many patients taking statins report muscle-related symptoms that prevent the use of guideline recommended doses. Patients with reported intolerance to statins have a high risk of cardiovascular events. Clinical strategies that optimize cardiovascular risk reduction through LDL-C lowering need to be applied in patients experiencing intolerable side effects that they attribute to statins. In this paper, the authors review definitions of statin intolerance, propose algorithms to better define statin intolerance, and describe approaches to optimize cardiovascular risk reduction among individuals reporting statin-associated muscle symptoms.

Original languageEnglish
Pages (from-to)1290-1301
Number of pages12
JournalJournal of the American College of Cardiology
Issue number10
Publication statusPublished - Sep 5 2017


  • cardiovascular disease
  • low-density lipoprotein
  • myalgia
  • myopathy
  • statin intolerance

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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