TY - JOUR
T1 - Optimizing the time-frame for the definition of bleeding-related death after acute variceal bleeding in cirrhosis
AU - Merkel, Carlo
AU - Gatta, Angelo
AU - Bellumat, Antonio
AU - Bolognesi, Massimo
AU - Borsato, Lino
AU - Caregaro, Lorenza
AU - Cavallarin, Giorgio
AU - Cielo, Roberto
AU - Cristina, Pierantonio
AU - Cucci, Elisabetta
AU - Donada, Carlo
AU - Donadon, Valter
AU - Enzo, Edda
AU - Marin, Renato
AU - Mazzaro, Cesare
AU - Sacerdoti, David
AU - Torboli, Pierluigi
PY - 1996
Y1 - 1996
N2 - Objective: To identify the best time-frame for defining bleeding-related death after variceal bleeding in patients with cirrhosis. Design: Prospective long-term evaluation of a cohort of 155 patients admitted with variceal bleeding. Setting: Eight medical departments in seven hospitals in north-eastern Italy. Methods: Non-linear regression analysis of a hazard curve for death, and Cox's multiple regression analyses using different zero-time points. Results: Cumulative hazard plots gave two slopes, the first corresponding to the risk of death from acute bleeding, the second a baseline risk of death. The first 30 days were outside the confidence limits of the regression curve for the baseline risk of death. Using Cox's regression analysis, the significant predictors of overall mortality risk were balanced between factors related to severity of bleeding and those related to severity of liver disease. If only deaths occurring after 30 days were considered, only predictors related to the severity of liver disease were found to be of importance. Conclusion: Thirty days after bleeding is considered to be a reasonable time-frame for the definition of bleeding-related death in patients with cirrhosis and variceal bleeding.
AB - Objective: To identify the best time-frame for defining bleeding-related death after variceal bleeding in patients with cirrhosis. Design: Prospective long-term evaluation of a cohort of 155 patients admitted with variceal bleeding. Setting: Eight medical departments in seven hospitals in north-eastern Italy. Methods: Non-linear regression analysis of a hazard curve for death, and Cox's multiple regression analyses using different zero-time points. Results: Cumulative hazard plots gave two slopes, the first corresponding to the risk of death from acute bleeding, the second a baseline risk of death. The first 30 days were outside the confidence limits of the regression curve for the baseline risk of death. Using Cox's regression analysis, the significant predictors of overall mortality risk were balanced between factors related to severity of bleeding and those related to severity of liver disease. If only deaths occurring after 30 days were considered, only predictors related to the severity of liver disease were found to be of importance. Conclusion: Thirty days after bleeding is considered to be a reasonable time-frame for the definition of bleeding-related death in patients with cirrhosis and variceal bleeding.
KW - Gastrointestinal bleeding
KW - Oesophageal varices
KW - Portal hypertension
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M3 - Article
C2 - 8900913
AN - SCOPUS:9044248592
VL - 8
SP - 75
EP - 79
JO - European Journal of Gastroenterology and Hepatology
JF - European Journal of Gastroenterology and Hepatology
SN - 0954-691X
IS - 1
ER -