Optimizing utilization of kidneys from deceased donors over 60 years: Five-year outcomes after implementation of a combined clinical and histological allocation algorithm

Pierobon Elisa Sefora, Sandrini Silvio, De Fazio Nicola, Rossini Giuseppe, Fontana Iris, Boschiero Luigino, Gropuzzo Maria, Gotti Eliana, Donati Donato, Minetti Enrico, Gandolfo Maria Teresa, Brunello Anna, Libetta Carmelo, Secchi Antonio, Chiaramonte Stefano, Rigotti Paolo

Research output: Contribution to journalArticlepeer-review

Abstract

Summary This 5 year observational multicentre study conducted in the Nord Italian Transplant programme area evaluated outcomes in patients receiving kidneys from donors over 60 years allocated according to a combined clinical and histological algorithm. Low-risk donors 60-69 years without risk factors were allocated to single kidney transplant (LR-SKT) based on clinical criteria. Biopsy was performed in donors over 70 years or 60-69 years with risk factors, allocated to Single (HR-SKT) or Dual kidney transplant (HR-DKT) according to the severity of histological damage. Forty HR-DKTs, 41 HR-SKTs and 234 LR-SKTs were evaluated. Baseline differences generally reflected stratification and allocation criteria. Patient and graft (death censored) survival were 90% and 92% for HR-DKT, 85% and 89% for HR-SKT, 88% and 87% for LR-SKT. The algorithm appeared user-friendly in daily practice and was safe and efficient, as demonstrated by satisfactory outcomes in all groups at 5 years. Clinical criteria performed well in low-risk donors. The excellent outcomes observed in DKTs call for fine-tuning of cut-off scores for allocation to DKT or SKT in high-risk patients.

Original languageEnglish
Pages (from-to)833-841
Number of pages9
JournalTransplant International
Volume26
Issue number8
DOIs
Publication statusPublished - Aug 2013

Keywords

  • allocation algorithm
  • DKT
  • ECD
  • graft survival
  • kidney transplantation

ASJC Scopus subject areas

  • Transplantation

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