Optimum bile acid treatment for rapid gall stone dissolution

R. P. Jazrawi, M. G. Pigozzi, G. Galatola, A. Lanzini, T. C. Northfield

Research output: Contribution to journalArticle

Abstract

To determine the optimum bile acid regimen for rapid gall stone dissolution, 48 gall stone patients were divided into four groups of 12 according to stone diameter and were randomly allocated to receive one of four treatment regimens: bedtime or mealtime chenodeoxycholic acid (CDCA, 12 mg/kg/day) and bedtime or mealtime ursodeoxycholic acid (UDCA, 12 mg/kg/day). An additional 10 patients treated with a combination of CDCA plus UDCA (each 6 mg/kg/day) at bedtime were matched with the 10 patients on bedtime CDCA and the 10 on bedtime UDCA. The gall stone dissolution rates at six and 12 months were determined by standardised oral cholecystography and expressed as the percentage reduction in the gall stone volume after treatment. The gall stone dissolution rate at six months was higher for UDCA than CDCA treatment (median 78% v 48%, p

Original languageEnglish
Pages (from-to)381-386
Number of pages6
JournalGut
Volume33
Issue number3
Publication statusPublished - Mar 1992

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ASJC Scopus subject areas

  • Gastroenterology

Cite this

Jazrawi, R. P., Pigozzi, M. G., Galatola, G., Lanzini, A., & Northfield, T. C. (1992). Optimum bile acid treatment for rapid gall stone dissolution. Gut, 33(3), 381-386.