Oral administration of fluoride in pregnant women, and the relation between concentration in maternal plasma and in amniotic fluid

E. Brambilla, G. Belluomo, A. Malerba, M. Buscaglia, L. Strohmenger

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The aim was to measure the ionic fluoride concentration in maternal plasma and in amniotic fluid after oral administration of different doses of sodium fluoride (NaF) to 121 pregnant women. They were divided into six groups, according to the dose administered; 0 for the control group and 0.25, 0.50, 0.75, 1.00 or 1.25 mg of F- for the others. The subjects were instructed to take the corresponding NaF dose both 24 and 3 h before amniocentesis. Amniotic fluid (5 ml) and venous blood (5 ml) were obtained from each subject. Ionic fluoride concentration was measured with an expanded-scale potentiometer and a selective fluoride electrode. The results showed that F- concentration in amniotic fluid and, presumably, in fetal circulation, was not significantly different in groups taking 0.25, 0.50, 0.75 or 1.00 mg/day of F-. The F- concentration in amniotic fluid of the 1.25 mg/day group was, however, significantly higher than in all the other groups.

Original languageEnglish
Pages (from-to)991-994
Number of pages4
JournalArchives of Oral Biology
Volume39
Issue number11
DOIs
Publication statusPublished - 1994

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Amniotic Fluid
Fluorides
Oral Administration
Pregnant Women
Mothers
Sodium Fluoride
Amniocentesis
Electrodes
Control Groups

Keywords

  • amniotic fluid
  • fluoride
  • placenta
  • plasma

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Oral administration of fluoride in pregnant women, and the relation between concentration in maternal plasma and in amniotic fluid. / Brambilla, E.; Belluomo, G.; Malerba, A.; Buscaglia, M.; Strohmenger, L.

In: Archives of Oral Biology, Vol. 39, No. 11, 1994, p. 991-994.

Research output: Contribution to journalArticle

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AU - Strohmenger, L.

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