Oral administration of forskolin and rutin contributes to intraocular pressure control in primary open angle glaucoma patients under maximum tolerated medical therapy

Michele Vetrugno, Maurizio G. Uva, Vincenzo Russo, Michele Iester, Marco Ciancaglini, Paolo Brusini, Marco Centofanti, Luca M. Rossetti

Research output: Contribution to journalArticle


Background: Tight control of intraocular pressure (IOP) is still the only therapeutic approach available for the treatment of primary open angle glaucoma (POAG). However, some patients do not respond adequately to hypotonising drugs, and despite multiple drug combinations they cannot reach their target IOP. Forskolin is a natural compound that has already shown efficacy in IOP reduction following topical application. Purpose: The aim of this study was to evaluate the effects on the IOP of a food supplement containing forskolin and rutin when administered to POAG patients under maximum tolerated medical therapy (MTMT) and on a waiting list for filtrating surgery to further decrease their IOP. Methods: The design of the study was open and case-controlled. Ninety-seven (52 in the treatment group, and 45 in the reference group) patients were enrolled in 8 different glaucoma centers in Italy, all under MTMT and with IOP enrollment values above their target pressure. During the 30 days before surgery, patients in the treatment group were prescribed 2 tablets per day of a food supplement containing rutin and forskolin in addition to their usual topical drug treatment. Their IOP values were measured at 3 time points during the day, at enrollment and once a week until surgery. Control patients continued only with their normal topical therapy. Results: All patients in the treatment group, independently of the combination drug therapy that they were taking, showed a further 10% decrease (P

Original languageEnglish
Pages (from-to)536-541
Number of pages6
JournalJournal of Ocular Pharmacology and Therapeutics
Issue number5
Publication statusPublished - Oct 1 2012


ASJC Scopus subject areas

  • Pharmacology (medical)
  • Ophthalmology
  • Pharmacology

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