Oral Amino Acid Supplements Improve Exercise Capacities in Elderly Patients with Chronic Heart Failure

Roberto Aquilani, Simona Viglio, Paolo Iadarola, Cristina Opasich, Amidio Testa, Francesco S. Dioguardi, Evasio Pasini

Research output: Contribution to journalArticle

Abstract

We investigated whether 30 days of oral supplementation with a special mixture of amino acids (AAs), together with conventional therapy, could improve exercise capacity in elderly outpatients with chronic heart failure (CHF). A group of 95 outpatients (12 women and 83 men; New York Heart Association class II-III) aged 65-74 years were studied. This was a randomized, double-blind, placebo-controlled study. The patients performed a basal exercise test and were then randomly assigned to a special oral nutritional mixture of AAs 4 g twice daily (n = 43) or placebo (n = 42). After 30 days we repeated the exercise test. In both tests we measured the following: oxygen consumption (VO2), CO2 production (VCO2), minute ventilation (VE), oxygen cost of ventilation (VO2/VE), CO2 elimination per liter of ventilation (VCO2/VE), respiratory exchange ratio (RER; calculated as VCO2/VO2), oxygen pulse (VO2/heart rate [HR]) and anaerobic metabolism during exercise (ANA-VO2). At day 30, exercise capacity in the AA group had improved (+11 ± 8 W, p 2 increased by 1.2 ± 1.1 mL/kg per min (+12.7% ± 13%; p2/HR improved by 1.5 ± 1.4 mL O2 per heartbeat (p 2 was reduced by >50% in patients on AAs (from 20.2 ± 10 mL/kg at day 0 to 10.9 ± 5 mL/kg at day 30; p

Original languageEnglish
JournalThe American Journal of Cardiology
Volume101
Issue number11 SUPPL.
DOIs
Publication statusPublished - Jun 2 2008

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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