Oral anticancer therapy project: Clinical utility of a specific home care nursing programme on behalf of Italian Association of Medical Oncology (AIOM): Journal of Clinical Nursing

M. Cirillo, L. Carlucci, L. Legramandi, E. Baldini, C. Sacco, V. Zagonel, S. Leo, F. Di Fabio, G. Tonini, M.L. Meacci, A. Tartarone, D. Farci, G. Tortora, M. Zaninelli, V.M. Valori, S. Cinieri, F. Carrozza, E. Barbato, V. Fabbroni, E. CretellaT. Gamucci, G. Lunardi, S. Zamboni, G. Micallo, S. Cascinu, C. Pinto, S. Gori

Research output: Contribution to journalArticle

Abstract

Aims and objectives: To assess the effectiveness of a specific home care nursing programme in addition to standard care in patients (pts) receiving oral anticancer treatments. Background: Oral anticancer therapy present challenges for pts since treatment is a home-based therapy. This study evaluates the potentiality of a home care nursing programme in decreasing hospital accesses for not severe toxicity. Methods: This is an open-label, multicentre, randomised trial including pts who were receiving an anticancer oral drug. The study complies with the CONSORT checklist published in 2010. Concomitant use of radiation therapy, intravenous or metronomic therapies, or the intake of previous oral drugs was not allowed. Pts were randomly assigned to home care nursing programme (A) or standard care (B). In arm A, dedicated nurses provided information to pts, a daily record on which pts would take note of drugs and dosages and a telephone monitoring during the first two cycles of therapy. The primary outcome was the reduction in improper hospital accesses for grade 1–2 toxicity according to CTCAE v4.0. Results: Out of 432 randomised pts, 378 were analysed (184 pts in arm A and 194 in arm B). Hospital accesses were observed in 41 pts in arm A and in 42 pts in arm B (22.3% vs. 21.6%, respectively). No difference was detected in proportion of improper accesses between arm A and arm B (29.3% vs. 23.8%, respectively). Conclusions: Our experience failed to support the role of a specific home care nursing programme for pts taking oral chemotherapy. An improved attention to specific educational practice and information offered to pts can explain these results. Relevance to clinical practice: Our results underline the role of nurse educational practice and information offered to patients. A careful nurse information of patients about drugs is essential to reduce toxicities avoiding the opportunity of a specific home monitoring. © 2019 John Wiley & Sons Ltd
Original languageEnglish
JournalJ. Clin. Nurs.
DOIs
Publication statusAccepted/In press - 2019

Keywords

  • nurse monitoring
  • oral anticancer therapy
  • patient education

Cite this

Oral anticancer therapy project: Clinical utility of a specific home care nursing programme on behalf of Italian Association of Medical Oncology (AIOM) : Journal of Clinical Nursing. / Cirillo, M.; Carlucci, L.; Legramandi, L.; Baldini, E.; Sacco, C.; Zagonel, V.; Leo, S.; Di Fabio, F.; Tonini, G.; Meacci, M.L.; Tartarone, A.; Farci, D.; Tortora, G.; Zaninelli, M.; Valori, V.M.; Cinieri, S.; Carrozza, F.; Barbato, E.; Fabbroni, V.; Cretella, E.; Gamucci, T.; Lunardi, G.; Zamboni, S.; Micallo, G.; Cascinu, S.; Pinto, C.; Gori, S.

In: J. Clin. Nurs., 2019.

Research output: Contribution to journalArticle

Cirillo, M, Carlucci, L, Legramandi, L, Baldini, E, Sacco, C, Zagonel, V, Leo, S, Di Fabio, F, Tonini, G, Meacci, ML, Tartarone, A, Farci, D, Tortora, G, Zaninelli, M, Valori, VM, Cinieri, S, Carrozza, F, Barbato, E, Fabbroni, V, Cretella, E, Gamucci, T, Lunardi, G, Zamboni, S, Micallo, G, Cascinu, S, Pinto, C & Gori, S 2019, 'Oral anticancer therapy project: Clinical utility of a specific home care nursing programme on behalf of Italian Association of Medical Oncology (AIOM): Journal of Clinical Nursing', J. Clin. Nurs.. https://doi.org/10.1111/jocn.15064
Cirillo, M. ; Carlucci, L. ; Legramandi, L. ; Baldini, E. ; Sacco, C. ; Zagonel, V. ; Leo, S. ; Di Fabio, F. ; Tonini, G. ; Meacci, M.L. ; Tartarone, A. ; Farci, D. ; Tortora, G. ; Zaninelli, M. ; Valori, V.M. ; Cinieri, S. ; Carrozza, F. ; Barbato, E. ; Fabbroni, V. ; Cretella, E. ; Gamucci, T. ; Lunardi, G. ; Zamboni, S. ; Micallo, G. ; Cascinu, S. ; Pinto, C. ; Gori, S. / Oral anticancer therapy project: Clinical utility of a specific home care nursing programme on behalf of Italian Association of Medical Oncology (AIOM) : Journal of Clinical Nursing. In: J. Clin. Nurs. 2019.
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title = "Oral anticancer therapy project: Clinical utility of a specific home care nursing programme on behalf of Italian Association of Medical Oncology (AIOM): Journal of Clinical Nursing",
abstract = "Aims and objectives: To assess the effectiveness of a specific home care nursing programme in addition to standard care in patients (pts) receiving oral anticancer treatments. Background: Oral anticancer therapy present challenges for pts since treatment is a home-based therapy. This study evaluates the potentiality of a home care nursing programme in decreasing hospital accesses for not severe toxicity. Methods: This is an open-label, multicentre, randomised trial including pts who were receiving an anticancer oral drug. The study complies with the CONSORT checklist published in 2010. Concomitant use of radiation therapy, intravenous or metronomic therapies, or the intake of previous oral drugs was not allowed. Pts were randomly assigned to home care nursing programme (A) or standard care (B). In arm A, dedicated nurses provided information to pts, a daily record on which pts would take note of drugs and dosages and a telephone monitoring during the first two cycles of therapy. The primary outcome was the reduction in improper hospital accesses for grade 1–2 toxicity according to CTCAE v4.0. Results: Out of 432 randomised pts, 378 were analysed (184 pts in arm A and 194 in arm B). Hospital accesses were observed in 41 pts in arm A and in 42 pts in arm B (22.3{\%} vs. 21.6{\%}, respectively). No difference was detected in proportion of improper accesses between arm A and arm B (29.3{\%} vs. 23.8{\%}, respectively). Conclusions: Our experience failed to support the role of a specific home care nursing programme for pts taking oral chemotherapy. An improved attention to specific educational practice and information offered to pts can explain these results. Relevance to clinical practice: Our results underline the role of nurse educational practice and information offered to patients. A careful nurse information of patients about drugs is essential to reduce toxicities avoiding the opportunity of a specific home monitoring. {\circledC} 2019 John Wiley & Sons Ltd",
keywords = "nurse monitoring, oral anticancer therapy, patient education",
author = "M. Cirillo and L. Carlucci and L. Legramandi and E. Baldini and C. Sacco and V. Zagonel and S. Leo and {Di Fabio}, F. and G. Tonini and M.L. Meacci and A. Tartarone and D. Farci and G. Tortora and M. Zaninelli and V.M. Valori and S. Cinieri and F. Carrozza and E. Barbato and V. Fabbroni and E. Cretella and T. Gamucci and G. Lunardi and S. Zamboni and G. Micallo and S. Cascinu and C. Pinto and S. Gori",
note = "Export Date: 20 December 2019 CODEN: JCCNE Correspondence Address: Cirillo, M.; IRCCS Sacro Cuore Don Calabria HospitalItaly; email: massimo.cirillo@sacrocuore.it References: Banna, G.L., Collov{\`a}, E., Gebbia, V., Lipari, H., Giuffrida, P., Cavallaro, S., Ferra{\`u}, F., Anticancer oral therapy: Emerging related issues (2010) Cancer Treatment Reviews, 36, pp. 595-605. , https://doi.org/10.1016/j.ctrv.2010.04.005; Bedell, C.H., A changing paradigm for cancer treatment: The advent of new oral chemotherapy agents (2003) Clinical Journal of Oncology Nursing, 7, pp. 5-9. , https://doi.org/10.1188/03.CJON.S6.5-9; Bourmaud, A., Pacaut, C., Melis, A., Tinquaut, F., Magn{\'e}, N., Merrouche, Y., Chauvin, F., Is oral chemotherapy prescription safe for patients? A cross-sectional survey (2014) Annals of Oncology, 25, pp. 500-504. , https://doi.org/10.1093/annonc/mdt553; Cirillo, M., Lunardi, G., Coati, F., Ciccarelli, L., Alestra, S., Mariotto, M., Venturini, M., Management of oral anticancer drugs: Feasibility and patient approval of a specific monitoring program (2014) Tumori, 100, pp. 243-248; Ergolin, J.M., Promises and pitfalls of oral cancer chemotherapy (2009) Clinical Advances in Hematology & Oncology, 7, pp. 8-10; Gori, S., Di Maio, M., Pinto, C., Alabiso, O., Baldini, E., Barbato, E., Venturini, M., Impact of use of oral anticancer drugs on activity of Italian oncology practices: Results of a survey conducted by the Italian Society of Medical Oncology (AIOM) (2013) Tumori, 99, pp. 35-38. , https://doi.org/10.1177/030089161309900106; Griffin, M.C., Gilbert, R.E., Broadfield, L.H., Easty, A.E., Trbovich, P.L., Griffin, M.C., Trbovich, P.L., ReCap: Comparison of independent errors checks for oral versus intravenous chemotherapy (2016) Journal of Oncology Practice, 12, pp. e180-e186; Kav, S., Johnson, J., Rittenberg, C., Fernadez-Ortega, P., Suominen, T., Olsen, P.R., Clark-Snow, R., Role of the nurse in patient education and follow-up of people receiving oral chemotherapy treatment: An International survey (2008) Supportive Care in Cancer, 16, pp. 1075-1083. , https://doi.org/10.1007/s00520-007-0377-x; Molassiotis, A., Brearley, S., Saunders, M., Craven, O., Wardley, A., Farrell, C., Luker, K., Effectiveness of a home care nursing program in the symptom management of patients with colorectal and breast cancer receiving oral chemotherapy: A randomized, controlled trial (2009) Journal of Clinical Oncology, 27, pp. 6191-6198; Neuss, M.N., Polovich, M., McNiff, K., Esper, P., Gilmore, T.R., LeFebvre, K.B., Jacobson, J.O., 2013 updated American Society of Clinical Oncology/Oncology Nursing Society chemotherapy administration safety standards including standards for the safe administration and management of oral chemotherapy (2013) Journal of Oncology Practice, 9, pp. 5s-13s. , https://doi.org/10.1200/JOP.2013.000874; Schott, S., Schneeweiss, A., Reinhardt, J., Bruckner, T., Domschke, C., Sohn, C., Eichbaum, M.H., Acceptance of oral chemotherapy in breast cancer patients – A survey study (2011) BMC Cancer, 11, pp. 129-138. , https://doi.org/10.1186/1471-2407-11-129; Vanelli, M., Pedan, A., Liu, N., Hoar, J., Messier, D., Kiarsis, K., The role of patient inexperience in medication discontinuation: A retrospective analysis of medication nonpersistence in seven chronic illnesses (2009) Clinical Therapeutics, 31, pp. 2628-2652. , https://doi.org/10.1016/j.clinthera.2009.11.028; Walsh, K.E., Dodd, K.S., Seetharaman, K., Roblin, D.W., Herrinton, L.J., Von Worley, A., Gurwitz, J.H., Medication errors among adults and children with cancer in the outpatient setting (2009) Journal of Clinical Oncology, 27, pp. 891-896. , https://doi.org/10.1200/JCO.2008.18.6072; Weingart, S.N., Flug, J., Brouillard, D., Morway, L., Partridge, A., Bartel, S., Connor, M., Oral chemotherapy safety practices at US cancer centres: Questionnaire survey (2007) BMJ, 334, p. 407. , https://doi.org/10.1136/bmj.39069.489757.55; Weingart, S.N., Toro, J., Spencer, J., Duncombe, D., Gross, A., Bartel, S., Connor, M., Medication errors involving oral chemotherapy (2010) Cancer, 116, pp. 2455-2464. , https://doi.org/10.1002/cncr.25027; Winkeljohn, D.L., Adherence to oral cancer therapies: Nursing interventions (2010) Clinical Journal of Oncology Nursing, 14, pp. 461-466. , https://doi.org/10.1188/10.CJON.461-466; Zerillo, J.A., Pham, T.H., Kadlubek, P., Severson, J.A., Mackler, E., Jacobson, J.O., Blayney, D.W., Administration of oral chemotherapy: Results from three rounds of the quality oncology practice initiative (2015) Journal of Oncology Practice, 11, pp. e255-e261. , https://doi.org/10.1200/JOP.2014.001842",
year = "2019",
doi = "10.1111/jocn.15064",
language = "English",
journal = "J. Clin. Nurs.",
issn = "0962-1067",
publisher = "Wiley-Blackwell Publishing Ltd",

}

TY - JOUR

T1 - Oral anticancer therapy project: Clinical utility of a specific home care nursing programme on behalf of Italian Association of Medical Oncology (AIOM)

T2 - Journal of Clinical Nursing

AU - Cirillo, M.

AU - Carlucci, L.

AU - Legramandi, L.

AU - Baldini, E.

AU - Sacco, C.

AU - Zagonel, V.

AU - Leo, S.

AU - Di Fabio, F.

AU - Tonini, G.

AU - Meacci, M.L.

AU - Tartarone, A.

AU - Farci, D.

AU - Tortora, G.

AU - Zaninelli, M.

AU - Valori, V.M.

AU - Cinieri, S.

AU - Carrozza, F.

AU - Barbato, E.

AU - Fabbroni, V.

AU - Cretella, E.

AU - Gamucci, T.

AU - Lunardi, G.

AU - Zamboni, S.

AU - Micallo, G.

AU - Cascinu, S.

AU - Pinto, C.

AU - Gori, S.

N1 - Export Date: 20 December 2019 CODEN: JCCNE Correspondence Address: Cirillo, M.; IRCCS Sacro Cuore Don Calabria HospitalItaly; email: massimo.cirillo@sacrocuore.it References: Banna, G.L., Collovà, E., Gebbia, V., Lipari, H., Giuffrida, P., Cavallaro, S., Ferraù, F., Anticancer oral therapy: Emerging related issues (2010) Cancer Treatment Reviews, 36, pp. 595-605. , https://doi.org/10.1016/j.ctrv.2010.04.005; Bedell, C.H., A changing paradigm for cancer treatment: The advent of new oral chemotherapy agents (2003) Clinical Journal of Oncology Nursing, 7, pp. 5-9. , https://doi.org/10.1188/03.CJON.S6.5-9; Bourmaud, A., Pacaut, C., Melis, A., Tinquaut, F., Magné, N., Merrouche, Y., Chauvin, F., Is oral chemotherapy prescription safe for patients? A cross-sectional survey (2014) Annals of Oncology, 25, pp. 500-504. , https://doi.org/10.1093/annonc/mdt553; Cirillo, M., Lunardi, G., Coati, F., Ciccarelli, L., Alestra, S., Mariotto, M., Venturini, M., Management of oral anticancer drugs: Feasibility and patient approval of a specific monitoring program (2014) Tumori, 100, pp. 243-248; Ergolin, J.M., Promises and pitfalls of oral cancer chemotherapy (2009) Clinical Advances in Hematology & Oncology, 7, pp. 8-10; Gori, S., Di Maio, M., Pinto, C., Alabiso, O., Baldini, E., Barbato, E., Venturini, M., Impact of use of oral anticancer drugs on activity of Italian oncology practices: Results of a survey conducted by the Italian Society of Medical Oncology (AIOM) (2013) Tumori, 99, pp. 35-38. , https://doi.org/10.1177/030089161309900106; Griffin, M.C., Gilbert, R.E., Broadfield, L.H., Easty, A.E., Trbovich, P.L., Griffin, M.C., Trbovich, P.L., ReCap: Comparison of independent errors checks for oral versus intravenous chemotherapy (2016) Journal of Oncology Practice, 12, pp. e180-e186; Kav, S., Johnson, J., Rittenberg, C., Fernadez-Ortega, P., Suominen, T., Olsen, P.R., Clark-Snow, R., Role of the nurse in patient education and follow-up of people receiving oral chemotherapy treatment: An International survey (2008) Supportive Care in Cancer, 16, pp. 1075-1083. , https://doi.org/10.1007/s00520-007-0377-x; Molassiotis, A., Brearley, S., Saunders, M., Craven, O., Wardley, A., Farrell, C., Luker, K., Effectiveness of a home care nursing program in the symptom management of patients with colorectal and breast cancer receiving oral chemotherapy: A randomized, controlled trial (2009) Journal of Clinical Oncology, 27, pp. 6191-6198; Neuss, M.N., Polovich, M., McNiff, K., Esper, P., Gilmore, T.R., LeFebvre, K.B., Jacobson, J.O., 2013 updated American Society of Clinical Oncology/Oncology Nursing Society chemotherapy administration safety standards including standards for the safe administration and management of oral chemotherapy (2013) Journal of Oncology Practice, 9, pp. 5s-13s. , https://doi.org/10.1200/JOP.2013.000874; Schott, S., Schneeweiss, A., Reinhardt, J., Bruckner, T., Domschke, C., Sohn, C., Eichbaum, M.H., Acceptance of oral chemotherapy in breast cancer patients – A survey study (2011) BMC Cancer, 11, pp. 129-138. , https://doi.org/10.1186/1471-2407-11-129; Vanelli, M., Pedan, A., Liu, N., Hoar, J., Messier, D., Kiarsis, K., The role of patient inexperience in medication discontinuation: A retrospective analysis of medication nonpersistence in seven chronic illnesses (2009) Clinical Therapeutics, 31, pp. 2628-2652. , https://doi.org/10.1016/j.clinthera.2009.11.028; Walsh, K.E., Dodd, K.S., Seetharaman, K., Roblin, D.W., Herrinton, L.J., Von Worley, A., Gurwitz, J.H., Medication errors among adults and children with cancer in the outpatient setting (2009) Journal of Clinical Oncology, 27, pp. 891-896. , https://doi.org/10.1200/JCO.2008.18.6072; Weingart, S.N., Flug, J., Brouillard, D., Morway, L., Partridge, A., Bartel, S., Connor, M., Oral chemotherapy safety practices at US cancer centres: Questionnaire survey (2007) BMJ, 334, p. 407. , https://doi.org/10.1136/bmj.39069.489757.55; Weingart, S.N., Toro, J., Spencer, J., Duncombe, D., Gross, A., Bartel, S., Connor, M., Medication errors involving oral chemotherapy (2010) Cancer, 116, pp. 2455-2464. , https://doi.org/10.1002/cncr.25027; Winkeljohn, D.L., Adherence to oral cancer therapies: Nursing interventions (2010) Clinical Journal of Oncology Nursing, 14, pp. 461-466. , https://doi.org/10.1188/10.CJON.461-466; Zerillo, J.A., Pham, T.H., Kadlubek, P., Severson, J.A., Mackler, E., Jacobson, J.O., Blayney, D.W., Administration of oral chemotherapy: Results from three rounds of the quality oncology practice initiative (2015) Journal of Oncology Practice, 11, pp. e255-e261. , https://doi.org/10.1200/JOP.2014.001842

PY - 2019

Y1 - 2019

N2 - Aims and objectives: To assess the effectiveness of a specific home care nursing programme in addition to standard care in patients (pts) receiving oral anticancer treatments. Background: Oral anticancer therapy present challenges for pts since treatment is a home-based therapy. This study evaluates the potentiality of a home care nursing programme in decreasing hospital accesses for not severe toxicity. Methods: This is an open-label, multicentre, randomised trial including pts who were receiving an anticancer oral drug. The study complies with the CONSORT checklist published in 2010. Concomitant use of radiation therapy, intravenous or metronomic therapies, or the intake of previous oral drugs was not allowed. Pts were randomly assigned to home care nursing programme (A) or standard care (B). In arm A, dedicated nurses provided information to pts, a daily record on which pts would take note of drugs and dosages and a telephone monitoring during the first two cycles of therapy. The primary outcome was the reduction in improper hospital accesses for grade 1–2 toxicity according to CTCAE v4.0. Results: Out of 432 randomised pts, 378 were analysed (184 pts in arm A and 194 in arm B). Hospital accesses were observed in 41 pts in arm A and in 42 pts in arm B (22.3% vs. 21.6%, respectively). No difference was detected in proportion of improper accesses between arm A and arm B (29.3% vs. 23.8%, respectively). Conclusions: Our experience failed to support the role of a specific home care nursing programme for pts taking oral chemotherapy. An improved attention to specific educational practice and information offered to pts can explain these results. Relevance to clinical practice: Our results underline the role of nurse educational practice and information offered to patients. A careful nurse information of patients about drugs is essential to reduce toxicities avoiding the opportunity of a specific home monitoring. © 2019 John Wiley & Sons Ltd

AB - Aims and objectives: To assess the effectiveness of a specific home care nursing programme in addition to standard care in patients (pts) receiving oral anticancer treatments. Background: Oral anticancer therapy present challenges for pts since treatment is a home-based therapy. This study evaluates the potentiality of a home care nursing programme in decreasing hospital accesses for not severe toxicity. Methods: This is an open-label, multicentre, randomised trial including pts who were receiving an anticancer oral drug. The study complies with the CONSORT checklist published in 2010. Concomitant use of radiation therapy, intravenous or metronomic therapies, or the intake of previous oral drugs was not allowed. Pts were randomly assigned to home care nursing programme (A) or standard care (B). In arm A, dedicated nurses provided information to pts, a daily record on which pts would take note of drugs and dosages and a telephone monitoring during the first two cycles of therapy. The primary outcome was the reduction in improper hospital accesses for grade 1–2 toxicity according to CTCAE v4.0. Results: Out of 432 randomised pts, 378 were analysed (184 pts in arm A and 194 in arm B). Hospital accesses were observed in 41 pts in arm A and in 42 pts in arm B (22.3% vs. 21.6%, respectively). No difference was detected in proportion of improper accesses between arm A and arm B (29.3% vs. 23.8%, respectively). Conclusions: Our experience failed to support the role of a specific home care nursing programme for pts taking oral chemotherapy. An improved attention to specific educational practice and information offered to pts can explain these results. Relevance to clinical practice: Our results underline the role of nurse educational practice and information offered to patients. A careful nurse information of patients about drugs is essential to reduce toxicities avoiding the opportunity of a specific home monitoring. © 2019 John Wiley & Sons Ltd

KW - nurse monitoring

KW - oral anticancer therapy

KW - patient education

U2 - 10.1111/jocn.15064

DO - 10.1111/jocn.15064

M3 - Article

JO - J. Clin. Nurs.

JF - J. Clin. Nurs.

SN - 0962-1067

ER -