Oral anticoagulant use in octogenarian European patients with atrial fibrillation: A subanalysis of PREFER in AF

Olivier Hanon, Jean Sébastien Vidal, Jean Yves Le Heuzey, Paulus Kirchhof, Raffaele De Caterina, Josef Schmitt, Petra Laeis, Pier Mannuccio Mannucci, Maura Marcucci

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Background Few studies describe oral anticoagulant (OAC) prescription practices in very elderly patients with atrial fibrillation (AF). Methods In this sub-analysis of the PREFER in AF study, performed in 2012, patients were stratified according to age (< 80 [n = 5565] and ≥ 80 years [n = 1660]) and OAC treatment. Factors associated with OAC prescription were analyzed in a multivariate logistic regression model with backward elimination of variables least associated with OAC use. Results Patients ≥ 80 years presented with permanent AF more often (p < 0.0001) and reported fatigue and dyspnea more frequently (p < 0.0001) and palpitations less frequently (p < 0.0001) than patients < 80 years. Hypertension, stroke, heart failure, coronary heart disease, peripheral arterial disease, cancer, chronic kidney disease, and prior major bleeding were significantly more frequent in ≥ 80 years. Most patients were treated with OACs in both age groups. The overall use of vitamin K antagonists was similar in both groups (78.2% vs.78.2% p = 0.98), while the use of non-vitamin K antagonist OACs was lower in the ≥ 80 years old group than in the < 80 years group (4.5% vs. 6.6% p = 0.001). Among patients ≥ 80 years, prior stroke and heart failure were significantly associated with OAC use, whereas higher age, prior bleeding, paroxysmal AF, chronic hepatic disease, and difficulties with self-care were associated with no OAC use. Conclusions The current use of OAC in European AF patients was satisfactorily high in octogenarians, suggesting reasonable implementation of current guidelines. Interestingly, patients with poor quality of life were less often anticoagulated. This may warrant further studies.

Original languageEnglish
Pages (from-to)98-104
Number of pages7
JournalInternational Journal of Cardiology
Publication statusPublished - Apr 1 2017


  • Atrial fibrillation
  • Elderly: Oral anticoagulants: Multivariate analysis

ASJC Scopus subject areas

  • Medicine(all)
  • Cardiology and Cardiovascular Medicine


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