Abstract
Introduction. Oral mucositis represents one of the most frequent acute side effectsduring cancer therapies (chemotherapy and/or radiotherapy). It has been hypothesizedthat microbial (bacteria, fungi) overinfection of oral mucosa may enhance intensity andduration of mucositis. For this reason, a lot of studies have been performed in order toevaluate the efficacy of oral cavity bacterial decontamination and/or prevention andtreatment of oral candidiasis.Patients and methods. A comprehensive search of MEDLINE up to December 2007(with no language restriction) was performed. "Mucositis", "Chemotherapy" and"Radiotherapy" were the key words used.Results. Sixty clinical studies matched the key words listed above. Most papers werefocused on oral cavity bacterial decontamination and prevention and/or treatment of oral candidiasis. Recent international guidelines and critical reviews of literature were alsoconsidered.Conclusion. Available literature data do not support the use of preventive bacterialdecontamination of oral cavity by antimicrobial agents. On the contrary, some evidencesexist that prophylaxis of oral candidiasis with antimicotic agents (like fluconazole) couldto be efficacious to reduce the impact of oral mucositis but further larger randomizedtrials are needed.
| Original language | English |
|---|---|
| Title of host publication | Clinical Dentistry |
| Publisher | Nova Science Publishers, Inc. |
| Pages | 171-186 |
| Number of pages | 16 |
| ISBN (Print) | 9781611223545 |
| Publication status | Published - 2011 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Oral cavity overinfection during non surgical cancer therapies : Review of the literature. / Alterio, Daniela; Jereczek-Fossa, Barbara A.; Piperno, Gaia; Laudati, Antonio; Ferrari, Anna Maria; Giugliano, Gioacchino; Orecchia, Roberto.
Clinical Dentistry. Nova Science Publishers, Inc., 2011. p. 171-186.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Oral cavity overinfection during non surgical cancer therapies
T2 - Review of the literature
AU - Alterio, Daniela
AU - Jereczek-Fossa, Barbara A.
AU - Piperno, Gaia
AU - Laudati, Antonio
AU - Ferrari, Anna Maria
AU - Giugliano, Gioacchino
AU - Orecchia, Roberto
PY - 2011
Y1 - 2011
N2 - Introduction. Oral mucositis represents one of the most frequent acute side effectsduring cancer therapies (chemotherapy and/or radiotherapy). It has been hypothesizedthat microbial (bacteria, fungi) overinfection of oral mucosa may enhance intensity andduration of mucositis. For this reason, a lot of studies have been performed in order toevaluate the efficacy of oral cavity bacterial decontamination and/or prevention andtreatment of oral candidiasis.Patients and methods. A comprehensive search of MEDLINE up to December 2007(with no language restriction) was performed. "Mucositis", "Chemotherapy" and"Radiotherapy" were the key words used.Results. Sixty clinical studies matched the key words listed above. Most papers werefocused on oral cavity bacterial decontamination and prevention and/or treatment of oral candidiasis. Recent international guidelines and critical reviews of literature were alsoconsidered.Conclusion. Available literature data do not support the use of preventive bacterialdecontamination of oral cavity by antimicrobial agents. On the contrary, some evidencesexist that prophylaxis of oral candidiasis with antimicotic agents (like fluconazole) couldto be efficacious to reduce the impact of oral mucositis but further larger randomizedtrials are needed.
AB - Introduction. Oral mucositis represents one of the most frequent acute side effectsduring cancer therapies (chemotherapy and/or radiotherapy). It has been hypothesizedthat microbial (bacteria, fungi) overinfection of oral mucosa may enhance intensity andduration of mucositis. For this reason, a lot of studies have been performed in order toevaluate the efficacy of oral cavity bacterial decontamination and/or prevention andtreatment of oral candidiasis.Patients and methods. A comprehensive search of MEDLINE up to December 2007(with no language restriction) was performed. "Mucositis", "Chemotherapy" and"Radiotherapy" were the key words used.Results. Sixty clinical studies matched the key words listed above. Most papers werefocused on oral cavity bacterial decontamination and prevention and/or treatment of oral candidiasis. Recent international guidelines and critical reviews of literature were alsoconsidered.Conclusion. Available literature data do not support the use of preventive bacterialdecontamination of oral cavity by antimicrobial agents. On the contrary, some evidencesexist that prophylaxis of oral candidiasis with antimicotic agents (like fluconazole) couldto be efficacious to reduce the impact of oral mucositis but further larger randomizedtrials are needed.
UR - http://www.scopus.com/inward/record.url?scp=84891966458&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891966458&partnerID=8YFLogxK
M3 - Chapter
AN - SCOPUS:84891966458
SN - 9781611223545
SP - 171
EP - 186
BT - Clinical Dentistry
PB - Nova Science Publishers, Inc.
ER -