Introduction. Oral mucositis represents one of the most frequent acute side effects during cancer therapies (chemotherapy and/or radiotherapy). It has been hypo the sized that microbial (bacteria, fungi) over infection of oral mucosa may enhance intensity and duration of mucositis. For this reason, a lot of studies have been performed in order to evaluate the efficacy of oral cavity bacterial decontamination and/or prevention and treatment of oral candidiasis. Patients and methods. A comprehensive search of MEDLINE up to December 2007 (with no language restriction) was performed. "Mucositis", "Chemotherapy" and "Radiotherapy" were the key words used. Results. Sixty clinical studies matched the key words listed above. Most papers were focused on oral cavity bacterial decontamination and prevention and/or treatment of oral candidiasis. Recent international guidelines and critical reviews of literature were also considered. Conclusion. Available literature data do not support the use of preventive bacterial decontamination of oral cavity by antimicrobial agents. On the contrary, some evidences exist that prophylaxis of oral candidiasis with antimicotic agents (like fluconazole) could to be efficacious to reduce the impact of oral mucositis but further larger randomized trials are needed.
|Number of pages||16|
|Journal||International Journal of Clinical Dentistry|
|Publication status||Published - 2008|
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