La terapia di combinazione orale nel trattamento dei pazienti con ipertensione arteriosa polmonare: quali evidenze dagli studi a lungo termine?

Translated title of the contribution: Oral combination therapy for the treatment of patients with pulmonary arterial hypertension: what evidence from long-term studies?

Beatrice Pezzuto, Roberto Badagliacca, Roberto Poscia, Roberto Torre, Stefano Ghio, Laura Scelsi, Alessandra Greco, Michele D'Alto, Paola Argiento, Patrizio Vitulo, Francesco Fedele, Carmine Dario Vizza

Research output: Contribution to journalArticlepeer-review

Abstract

The introduction of specific drugs for the treatment of pulmonary arterial hypertension over the last 20 years has led to an improvement of clinical and hemodynamic conditions and prognosis of affected patients. The use of combination therapy has made it possible to act simultaneously on several biological pathways involved in the etiopathogenesis of the disease. However, although the diagnosis and management have radically changed in recent years, the disease remains progressive and often fatal. The purpose of this paper is to review and discuss the results of the main clinical trials and the future perspectives of combination strategies for the treatment of pulmonary arterial hypertension.

Translated title of the contributionOral combination therapy for the treatment of patients with pulmonary arterial hypertension: what evidence from long-term studies?
Original languageItalian
Pages (from-to)854-861
Number of pages8
JournalGiornale Italiano di Cardiologia
Volume18
Issue number12
DOIs
Publication statusPublished - Dec 2017

Keywords

  • English Abstract
  • Journal Article

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