Oral contraceptive use and risk of colorectal cancer

Esteve Fernandez, Carlo La Vecchia, Silvia Franceschi, Claudia Braga, Renato Talamini, Eva Negri, Fabio Parazzini

Research output: Contribution to journalArticle

Abstract

To evaluate the relation between oral contraceptives and colon and rectal cancer, we analyzed combined data from two case-control studies conducted in six Italian regions between 1985 and 1996. The studies included 803 women with incident colon cancer, 429 with rectal cancer, and 2,793 controls with acute, nonneoplastic, nondigestive, non-hormone-related disorders. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) from unconditional multiple logistic regression equations, including terms for age, center/study period, education, family history of colorectal cancer, menopausal status, age at menopause, parity, use of hormone replacement therapy, body mass index [weight (kg) per height squared (m2)], and total energy intake. Ever-use of oral contraceptives was inversely associated with colon cancer (OR = 0.63; 95% CI = 0.45-0.87) and rectal cancer (OR = 0.66; 95% CI = 0.431.01). Duration of use of oral contraceptives was inversely related to risk of colon but not rectal cancer. This study suggests that women who have ever used oral contraceptives are at lower risk of colon and rectal cancer.

Original languageEnglish
Pages (from-to)295-300
Number of pages6
JournalEpidemiology
Volume9
Issue number3
Publication statusPublished - May 1998

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Rectal Neoplasms
Oral Contraceptives
Colorectal Neoplasms
Colonic Neoplasms
Odds Ratio
Confidence Intervals
Hormone Replacement Therapy
Menopause
Parity
Energy Intake
Case-Control Studies
Colon
Body Mass Index
Logistic Models
Education
Weights and Measures

Keywords

  • Case-control study
  • Colorectal neoplasms
  • Estrogens
  • Italy
  • Oral contraceptive use

ASJC Scopus subject areas

  • Epidemiology

Cite this

Fernandez, E., La Vecchia, C., Franceschi, S., Braga, C., Talamini, R., Negri, E., & Parazzini, F. (1998). Oral contraceptive use and risk of colorectal cancer. Epidemiology, 9(3), 295-300.

Oral contraceptive use and risk of colorectal cancer. / Fernandez, Esteve; La Vecchia, Carlo; Franceschi, Silvia; Braga, Claudia; Talamini, Renato; Negri, Eva; Parazzini, Fabio.

In: Epidemiology, Vol. 9, No. 3, 05.1998, p. 295-300.

Research output: Contribution to journalArticle

Fernandez, E, La Vecchia, C, Franceschi, S, Braga, C, Talamini, R, Negri, E & Parazzini, F 1998, 'Oral contraceptive use and risk of colorectal cancer', Epidemiology, vol. 9, no. 3, pp. 295-300.
Fernandez E, La Vecchia C, Franceschi S, Braga C, Talamini R, Negri E et al. Oral contraceptive use and risk of colorectal cancer. Epidemiology. 1998 May;9(3):295-300.
Fernandez, Esteve ; La Vecchia, Carlo ; Franceschi, Silvia ; Braga, Claudia ; Talamini, Renato ; Negri, Eva ; Parazzini, Fabio. / Oral contraceptive use and risk of colorectal cancer. In: Epidemiology. 1998 ; Vol. 9, No. 3. pp. 295-300.
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