Abstract
To evaluate the relation between oral contraceptives and colon and rectal cancer, we analyzed combined data from two case-control studies conducted in six Italian regions between 1985 and 1996. The studies included 803 women with incident colon cancer, 429 with rectal cancer, and 2,793 controls with acute, nonneoplastic, nondigestive, non-hormone-related disorders. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) from unconditional multiple logistic regression equations, including terms for age, center/study period, education, family history of colorectal cancer, menopausal status, age at menopause, parity, use of hormone replacement therapy, body mass index [weight (kg) per height squared (m2)], and total energy intake. Ever-use of oral contraceptives was inversely associated with colon cancer (OR = 0.63; 95% CI = 0.45-0.87) and rectal cancer (OR = 0.66; 95% CI = 0.431.01). Duration of use of oral contraceptives was inversely related to risk of colon but not rectal cancer. This study suggests that women who have ever used oral contraceptives are at lower risk of colon and rectal cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 295-300 |
| Number of pages | 6 |
| Journal | Epidemiology |
| Volume | 9 |
| Issue number | 3 |
| Publication status | Published - May 1998 |
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Keywords
- Case-control study
- Colorectal neoplasms
- Estrogens
- Italy
- Oral contraceptive use
ASJC Scopus subject areas
- Epidemiology
Cite this
Oral contraceptive use and risk of colorectal cancer. / Fernandez, Esteve; La Vecchia, Carlo; Franceschi, Silvia; Braga, Claudia; Talamini, Renato; Negri, Eva; Parazzini, Fabio.
In: Epidemiology, Vol. 9, No. 3, 05.1998, p. 295-300.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Oral contraceptive use and risk of colorectal cancer
AU - Fernandez, Esteve
AU - La Vecchia, Carlo
AU - Franceschi, Silvia
AU - Braga, Claudia
AU - Talamini, Renato
AU - Negri, Eva
AU - Parazzini, Fabio
PY - 1998/5
Y1 - 1998/5
N2 - To evaluate the relation between oral contraceptives and colon and rectal cancer, we analyzed combined data from two case-control studies conducted in six Italian regions between 1985 and 1996. The studies included 803 women with incident colon cancer, 429 with rectal cancer, and 2,793 controls with acute, nonneoplastic, nondigestive, non-hormone-related disorders. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) from unconditional multiple logistic regression equations, including terms for age, center/study period, education, family history of colorectal cancer, menopausal status, age at menopause, parity, use of hormone replacement therapy, body mass index [weight (kg) per height squared (m2)], and total energy intake. Ever-use of oral contraceptives was inversely associated with colon cancer (OR = 0.63; 95% CI = 0.45-0.87) and rectal cancer (OR = 0.66; 95% CI = 0.431.01). Duration of use of oral contraceptives was inversely related to risk of colon but not rectal cancer. This study suggests that women who have ever used oral contraceptives are at lower risk of colon and rectal cancer.
AB - To evaluate the relation between oral contraceptives and colon and rectal cancer, we analyzed combined data from two case-control studies conducted in six Italian regions between 1985 and 1996. The studies included 803 women with incident colon cancer, 429 with rectal cancer, and 2,793 controls with acute, nonneoplastic, nondigestive, non-hormone-related disorders. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) from unconditional multiple logistic regression equations, including terms for age, center/study period, education, family history of colorectal cancer, menopausal status, age at menopause, parity, use of hormone replacement therapy, body mass index [weight (kg) per height squared (m2)], and total energy intake. Ever-use of oral contraceptives was inversely associated with colon cancer (OR = 0.63; 95% CI = 0.45-0.87) and rectal cancer (OR = 0.66; 95% CI = 0.431.01). Duration of use of oral contraceptives was inversely related to risk of colon but not rectal cancer. This study suggests that women who have ever used oral contraceptives are at lower risk of colon and rectal cancer.
KW - Case-control study
KW - Colorectal neoplasms
KW - Estrogens
KW - Italy
KW - Oral contraceptive use
UR - http://www.scopus.com/inward/record.url?scp=0031899818&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031899818&partnerID=8YFLogxK
M3 - Article
C2 - 9583422
AN - SCOPUS:0031899818
VL - 9
SP - 295
EP - 300
JO - Epidemiology
JF - Epidemiology
SN - 1044-3983
IS - 3
ER -