Oral contraceptive use, thrombophilia and their interaction in young women with ischemic stroke

Ida Martinelli, Tullia Battaglioli, Ilaria Burgo, Sandro Di Domenico, Pier Mannuccio Mannucci

Research output: Contribution to journalArticle


To investigate the role of oral contraceptives and their interaction with thrombophilia in ischemic stroke, a case-control study on women with a first ischemic stroke when younger than 45 years was carried out. Oral contraceptives doubled the risk of ischemic stroke in the first 6-18 months of use and hyperhomocysteinemia increased the risk by 3.5-fold. Carriers of factor V Leiden or prothrombin G20210A were not found to have a statistically significant increased risk. The risk of ischemic stroke in oral contraceptive users was 13 times higher in women who were also carriers of factor V Leiden and 9 times higher in those who also had hyperhomocysteinemia.

Original languageEnglish
Pages (from-to)844-847
Number of pages4
Issue number6
Publication statusPublished - Jun 2006



  • Genetics
  • Homocysteinemia
  • Risk factors
  • Thrombophilia

ASJC Scopus subject areas

  • Hematology

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