Oral contraceptives and benign breast disease: A case-control study

Silvia Franceschi, Carlo La Vecchia, Fabio Parazzini, Monica Fasoli, Michela Regallo, Adriano Decarli, Giuseppe Gallus, Gianni Tognoni

Research output: Contribution to journalArticlepeer-review


The relationship between benign breast disease and use of oral contraceptives was analyzed in a case-control study conducted in Milan with 288 cases of clinically relevant and histologically confirmed benign breast disease and 285 age-matched controls with a spectrum of acute conditions apparently unrelated to use of oral contraceptives. Compared to the risk for women who had never used oral contraceptives, the relative risk for users was 1.0 (95% confidence interval: 0.6 to 1.5). There was no significant association with duration of use; however, a significantly lower relative risk was found in women using oral contraceptives during the year before breast biopsy (relative risk: 0.4; 95% confidence interval: 0.2 to 0.8). The protection in current users increased with increasing duration of use. In spite of this finding, the overall results of the present study do not support the hypothesis that oral contraceptive use protects against development of histologically confirmed and clinically relevant benign breast disease.

Original languageEnglish
Pages (from-to)602-606
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Issue number6
Publication statusPublished - Jul 15 1984

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynaecology


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