Abstract
The relationship between the use of combbination oral contraceptives (OCs) and the risk of endometrial cancer was assessed in a case-control study conducted in the Swiss Canton of Vaud between 1 January 1988 and 31 July 1990. Subjects included 122 women aged 75 or less with histologically confirmed endometrial cancer, and 309 control women in hospital for acute conditions unrelated to OC use. Overall, 14 percent of cases and 27 percent of controls had ever used OCs, corresponding to a multivariate relative risk (RR) of 0.5 (95 percent confidence interval [CI]: 0.3. 0.8). The risk of endometrial cancer was found to be related inversely to duration of OC use: RR=1.0 for less than two years of OC use; 0.5 for two to five years; and 0.3 (95 percent CI: 0.1, 0.7) for more than five years. The protection appeared greater within 20 years since last use, and the RR rose to 0.8 after 20 or more years since last use; numbers are too small, however, for reliable inference from these subanalyses. No significant interaction or modifying effect was observed with other major factors related to endometrial cancer, including parity, body mass index, estrogen replacement therapy, and cigarette smoking. While this study provides further evidence for the protective effect of OCs against risk of endometrial cancer, the relationship requires continued evaluation to assess the long-term implications and public health impact of OC use.
| Original language | English |
|---|---|
| Pages (from-to) | 99-103 |
| Number of pages | 5 |
| Journal | Cancer Causes and Control |
| Volume | 2 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Mar 1991 |
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Keywords
- Case-control study
- endometrial cancer
- oral contraceptives
- Switzerland
ASJC Scopus subject areas
- Oncology
- Epidemiology
- Cancer Research
Cite this
Oral contraceptives and the risk of endometrial cancer. / Levi, Fabio; La Vecchia, Crrlo; Gulie, Cristina; Negri, Eva; Monnier, Véronique; Franceschi, Silvia; Delaloye, Jean Francois; De Grandi, Pierre.
In: Cancer Causes and Control, Vol. 2, No. 2, 03.1991, p. 99-103.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Oral contraceptives and the risk of endometrial cancer
AU - Levi, Fabio
AU - La Vecchia, Crrlo
AU - Gulie, Cristina
AU - Negri, Eva
AU - Monnier, Véronique
AU - Franceschi, Silvia
AU - Delaloye, Jean Francois
AU - De Grandi, Pierre
PY - 1991/3
Y1 - 1991/3
N2 - The relationship between the use of combbination oral contraceptives (OCs) and the risk of endometrial cancer was assessed in a case-control study conducted in the Swiss Canton of Vaud between 1 January 1988 and 31 July 1990. Subjects included 122 women aged 75 or less with histologically confirmed endometrial cancer, and 309 control women in hospital for acute conditions unrelated to OC use. Overall, 14 percent of cases and 27 percent of controls had ever used OCs, corresponding to a multivariate relative risk (RR) of 0.5 (95 percent confidence interval [CI]: 0.3. 0.8). The risk of endometrial cancer was found to be related inversely to duration of OC use: RR=1.0 for less than two years of OC use; 0.5 for two to five years; and 0.3 (95 percent CI: 0.1, 0.7) for more than five years. The protection appeared greater within 20 years since last use, and the RR rose to 0.8 after 20 or more years since last use; numbers are too small, however, for reliable inference from these subanalyses. No significant interaction or modifying effect was observed with other major factors related to endometrial cancer, including parity, body mass index, estrogen replacement therapy, and cigarette smoking. While this study provides further evidence for the protective effect of OCs against risk of endometrial cancer, the relationship requires continued evaluation to assess the long-term implications and public health impact of OC use.
AB - The relationship between the use of combbination oral contraceptives (OCs) and the risk of endometrial cancer was assessed in a case-control study conducted in the Swiss Canton of Vaud between 1 January 1988 and 31 July 1990. Subjects included 122 women aged 75 or less with histologically confirmed endometrial cancer, and 309 control women in hospital for acute conditions unrelated to OC use. Overall, 14 percent of cases and 27 percent of controls had ever used OCs, corresponding to a multivariate relative risk (RR) of 0.5 (95 percent confidence interval [CI]: 0.3. 0.8). The risk of endometrial cancer was found to be related inversely to duration of OC use: RR=1.0 for less than two years of OC use; 0.5 for two to five years; and 0.3 (95 percent CI: 0.1, 0.7) for more than five years. The protection appeared greater within 20 years since last use, and the RR rose to 0.8 after 20 or more years since last use; numbers are too small, however, for reliable inference from these subanalyses. No significant interaction or modifying effect was observed with other major factors related to endometrial cancer, including parity, body mass index, estrogen replacement therapy, and cigarette smoking. While this study provides further evidence for the protective effect of OCs against risk of endometrial cancer, the relationship requires continued evaluation to assess the long-term implications and public health impact of OC use.
KW - Case-control study
KW - endometrial cancer
KW - oral contraceptives
KW - Switzerland
UR - http://www.scopus.com/inward/record.url?scp=0026128744&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026128744&partnerID=8YFLogxK
U2 - 10.1007/BF00053128
DO - 10.1007/BF00053128
M3 - Article
C2 - 1873443
AN - SCOPUS:0026128744
VL - 2
SP - 99
EP - 103
JO - Cancer Causes and Control
JF - Cancer Causes and Control
SN - 0957-5243
IS - 2
ER -