Oral contraceptives versus physical exercise on cardiovascular and metabolic risk factors in women with polycystic ovary syndrome: a randomized controlled trial

F. Orio, G. Muscogiuri, F. Giallauria, S. Savastano, P. Bottiglieri, D. Tafuri, P. Predotti, G. Colarieti, A. Colao, S. Palomba

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Although oral contraceptives (OCs) are one the most widespread therapy in young polycystic ovary syndrome (PCOS) women and physical exercise represents a crucial first step in the treatment of overweight and obese PCOS, no studies were performed to compare the effects on cardiovascular risk (CVR) of OCs and physical exercise in PCOS. Objective: To compare the effects of OCs administration and physical exercise on the CVR, clinical, hormonal and metabolic parameters in PCOS women. Methods: One hundred and fifty PCOS women were enrolled and were randomized to OCs (3 mg drospirenone plus 30 μg ethinyloestradiol), structured exercise training programme (SETP) or polyvitamin tablets. The intervention phase study was of 6 months. Primary outcome was intima–media thickness (IMT) and flow-mediated dilation (FMD). Secondary outcomes were clinical, hormonal and metabolic changes. Results: A significant reduction of IMT and a significant increase of FMD were observed in the SETP group after treatment. Compared to baseline, in the SETP group, a significant improvement in anthropometric measures, insulin sensitivity indexes, lipid profile, cardiopulmonary function, inflammatory markers and frequency of menses was observed. Oral contraceptives use was associated with a significant decrease of hyperandrogenism and a significant improvement of frequency of menses. Further, OCs use had a neutral effect on CVR risk factors. Conclusion: OCs effectively treat hyperandrogenism and menstrual disturbances, while SETP is more effective in improving cardiometabolic profile and cardiopulmonary function in PCOS.

Original languageEnglish
Pages (from-to)764-771
Number of pages8
JournalClinical Endocrinology
Volume85
Issue number5
DOIs
Publication statusPublished - Nov 1 2016

Fingerprint

Polycystic Ovary Syndrome
Oral Contraceptives
Randomized Controlled Trials
Exercise
Hyperandrogenism
Education
Menstruation
Dilatation
Ethinyl Estradiol
Tablets
Oral Administration
Insulin Resistance
Therapeutics
Lipids

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Oral contraceptives versus physical exercise on cardiovascular and metabolic risk factors in women with polycystic ovary syndrome : a randomized controlled trial. / Orio, F.; Muscogiuri, G.; Giallauria, F.; Savastano, S.; Bottiglieri, P.; Tafuri, D.; Predotti, P.; Colarieti, G.; Colao, A.; Palomba, S.

In: Clinical Endocrinology, Vol. 85, No. 5, 01.11.2016, p. 764-771.

Research output: Contribution to journalArticle

Orio, F, Muscogiuri, G, Giallauria, F, Savastano, S, Bottiglieri, P, Tafuri, D, Predotti, P, Colarieti, G, Colao, A & Palomba, S 2016, 'Oral contraceptives versus physical exercise on cardiovascular and metabolic risk factors in women with polycystic ovary syndrome: a randomized controlled trial', Clinical Endocrinology, vol. 85, no. 5, pp. 764-771. https://doi.org/10.1111/cen.13112
Orio, F. ; Muscogiuri, G. ; Giallauria, F. ; Savastano, S. ; Bottiglieri, P. ; Tafuri, D. ; Predotti, P. ; Colarieti, G. ; Colao, A. ; Palomba, S. / Oral contraceptives versus physical exercise on cardiovascular and metabolic risk factors in women with polycystic ovary syndrome : a randomized controlled trial. In: Clinical Endocrinology. 2016 ; Vol. 85, No. 5. pp. 764-771.
@article{e6af128a7f7d49e8a7aeffc7c32e07d6,
title = "Oral contraceptives versus physical exercise on cardiovascular and metabolic risk factors in women with polycystic ovary syndrome: a randomized controlled trial",
abstract = "Background: Although oral contraceptives (OCs) are one the most widespread therapy in young polycystic ovary syndrome (PCOS) women and physical exercise represents a crucial first step in the treatment of overweight and obese PCOS, no studies were performed to compare the effects on cardiovascular risk (CVR) of OCs and physical exercise in PCOS. Objective: To compare the effects of OCs administration and physical exercise on the CVR, clinical, hormonal and metabolic parameters in PCOS women. Methods: One hundred and fifty PCOS women were enrolled and were randomized to OCs (3 mg drospirenone plus 30 μg ethinyloestradiol), structured exercise training programme (SETP) or polyvitamin tablets. The intervention phase study was of 6 months. Primary outcome was intima–media thickness (IMT) and flow-mediated dilation (FMD). Secondary outcomes were clinical, hormonal and metabolic changes. Results: A significant reduction of IMT and a significant increase of FMD were observed in the SETP group after treatment. Compared to baseline, in the SETP group, a significant improvement in anthropometric measures, insulin sensitivity indexes, lipid profile, cardiopulmonary function, inflammatory markers and frequency of menses was observed. Oral contraceptives use was associated with a significant decrease of hyperandrogenism and a significant improvement of frequency of menses. Further, OCs use had a neutral effect on CVR risk factors. Conclusion: OCs effectively treat hyperandrogenism and menstrual disturbances, while SETP is more effective in improving cardiometabolic profile and cardiopulmonary function in PCOS.",
author = "F. Orio and G. Muscogiuri and F. Giallauria and S. Savastano and P. Bottiglieri and D. Tafuri and P. Predotti and G. Colarieti and A. Colao and S. Palomba",
year = "2016",
month = "11",
day = "1",
doi = "10.1111/cen.13112",
language = "English",
volume = "85",
pages = "764--771",
journal = "Clinical Endocrinology",
issn = "0300-0664",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Oral contraceptives versus physical exercise on cardiovascular and metabolic risk factors in women with polycystic ovary syndrome

T2 - a randomized controlled trial

AU - Orio, F.

AU - Muscogiuri, G.

AU - Giallauria, F.

AU - Savastano, S.

AU - Bottiglieri, P.

AU - Tafuri, D.

AU - Predotti, P.

AU - Colarieti, G.

AU - Colao, A.

AU - Palomba, S.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Background: Although oral contraceptives (OCs) are one the most widespread therapy in young polycystic ovary syndrome (PCOS) women and physical exercise represents a crucial first step in the treatment of overweight and obese PCOS, no studies were performed to compare the effects on cardiovascular risk (CVR) of OCs and physical exercise in PCOS. Objective: To compare the effects of OCs administration and physical exercise on the CVR, clinical, hormonal and metabolic parameters in PCOS women. Methods: One hundred and fifty PCOS women were enrolled and were randomized to OCs (3 mg drospirenone plus 30 μg ethinyloestradiol), structured exercise training programme (SETP) or polyvitamin tablets. The intervention phase study was of 6 months. Primary outcome was intima–media thickness (IMT) and flow-mediated dilation (FMD). Secondary outcomes were clinical, hormonal and metabolic changes. Results: A significant reduction of IMT and a significant increase of FMD were observed in the SETP group after treatment. Compared to baseline, in the SETP group, a significant improvement in anthropometric measures, insulin sensitivity indexes, lipid profile, cardiopulmonary function, inflammatory markers and frequency of menses was observed. Oral contraceptives use was associated with a significant decrease of hyperandrogenism and a significant improvement of frequency of menses. Further, OCs use had a neutral effect on CVR risk factors. Conclusion: OCs effectively treat hyperandrogenism and menstrual disturbances, while SETP is more effective in improving cardiometabolic profile and cardiopulmonary function in PCOS.

AB - Background: Although oral contraceptives (OCs) are one the most widespread therapy in young polycystic ovary syndrome (PCOS) women and physical exercise represents a crucial first step in the treatment of overweight and obese PCOS, no studies were performed to compare the effects on cardiovascular risk (CVR) of OCs and physical exercise in PCOS. Objective: To compare the effects of OCs administration and physical exercise on the CVR, clinical, hormonal and metabolic parameters in PCOS women. Methods: One hundred and fifty PCOS women were enrolled and were randomized to OCs (3 mg drospirenone plus 30 μg ethinyloestradiol), structured exercise training programme (SETP) or polyvitamin tablets. The intervention phase study was of 6 months. Primary outcome was intima–media thickness (IMT) and flow-mediated dilation (FMD). Secondary outcomes were clinical, hormonal and metabolic changes. Results: A significant reduction of IMT and a significant increase of FMD were observed in the SETP group after treatment. Compared to baseline, in the SETP group, a significant improvement in anthropometric measures, insulin sensitivity indexes, lipid profile, cardiopulmonary function, inflammatory markers and frequency of menses was observed. Oral contraceptives use was associated with a significant decrease of hyperandrogenism and a significant improvement of frequency of menses. Further, OCs use had a neutral effect on CVR risk factors. Conclusion: OCs effectively treat hyperandrogenism and menstrual disturbances, while SETP is more effective in improving cardiometabolic profile and cardiopulmonary function in PCOS.

UR - http://www.scopus.com/inward/record.url?scp=84991206051&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84991206051&partnerID=8YFLogxK

U2 - 10.1111/cen.13112

DO - 10.1111/cen.13112

M3 - Article

C2 - 27219465

AN - SCOPUS:84991206051

VL - 85

SP - 764

EP - 771

JO - Clinical Endocrinology

JF - Clinical Endocrinology

SN - 0300-0664

IS - 5

ER -