Oral desensitisation with food is food-specific and protein-specific

Paolo Meglio, P. G. Giampietro, I. Gabriele, R. Carello, S. Avitabile, E. Galli

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The avoidance of food(s) is the main therapeutic approach to food allergy. Nevertheless, orally- or sublingually-administered food allergens have gained attention and a number of food-allergic children can tolerate gradually increasing amounts of cow's milk and hen's egg. Our purpose is to show that oral desensitisation with food is an allergen-specific therapeutic approach and for this, we describe 4 illustrative children with IgE-mediated food allergy. The first was allergic to cow's milk and hen's egg, the second to cow's milk, hen's egg and fish. Both underwent oral desensitisation to both cow's milk and hen's egg. The third child was allergic to cow's milk, hen's egg and fish and underwent oral desensitisation with cow's milk. The last child was allergic to raw but not to cooked/boiled hen's egg and underwent the oral desensitisation with hen's egg. The first 2 children reached the clinical tolerance to cow's milk after the cow's milk oral desensitisation, but reached the hen's egg tolerance only after the hen's egg oral desensitisation. Moreover, the second child did not tolerate fish after being desensitised to both cow's milk and hen's egg. The third child tolerated cow's milk, but not hen's egg and fish, at the end of the cow's milk oral desensitisation. The fourth child could tolerate the previously not tolerated raw hen's egg after the oral desensitisation with raw hen's egg. In conclusion, we indicate that oral desensitisation with food is allergen specific. The induction of the clinical tolerance to one food is not followed by the tolerance to the other food(s) that the patient is allergic to. To obtain a double or multiple food tolerance, separate desensitisation protocols, one for each food, have to be carried out. Oral desensitisation with food discriminates between raw and cooked proteins.

Original languageEnglish
Pages (from-to)803-811
Number of pages9
JournalInternational Journal of Immunopathology and Pharmacology
Volume24
Issue number3
Publication statusPublished - Jul 2011

Fingerprint

Ovum
Milk
Food
Proteins
Fishes
Allergens
Food Hypersensitivity
Immunoglobulin E

Keywords

  • Cow's milk allergy
  • Food allergy
  • Hen 's egg allergy
  • Oral desensitisation
  • Therapy for food allergy

ASJC Scopus subject areas

  • Pharmacology
  • Immunology
  • Immunology and Allergy

Cite this

Meglio, P., Giampietro, P. G., Gabriele, I., Carello, R., Avitabile, S., & Galli, E. (2011). Oral desensitisation with food is food-specific and protein-specific. International Journal of Immunopathology and Pharmacology, 24(3), 803-811.

Oral desensitisation with food is food-specific and protein-specific. / Meglio, Paolo; Giampietro, P. G.; Gabriele, I.; Carello, R.; Avitabile, S.; Galli, E.

In: International Journal of Immunopathology and Pharmacology, Vol. 24, No. 3, 07.2011, p. 803-811.

Research output: Contribution to journalArticle

Meglio, P, Giampietro, PG, Gabriele, I, Carello, R, Avitabile, S & Galli, E 2011, 'Oral desensitisation with food is food-specific and protein-specific', International Journal of Immunopathology and Pharmacology, vol. 24, no. 3, pp. 803-811.
Meglio P, Giampietro PG, Gabriele I, Carello R, Avitabile S, Galli E. Oral desensitisation with food is food-specific and protein-specific. International Journal of Immunopathology and Pharmacology. 2011 Jul;24(3):803-811.
Meglio, Paolo ; Giampietro, P. G. ; Gabriele, I. ; Carello, R. ; Avitabile, S. ; Galli, E. / Oral desensitisation with food is food-specific and protein-specific. In: International Journal of Immunopathology and Pharmacology. 2011 ; Vol. 24, No. 3. pp. 803-811.
@article{f959da3778614c0d960db52a0d0649e8,
title = "Oral desensitisation with food is food-specific and protein-specific",
abstract = "The avoidance of food(s) is the main therapeutic approach to food allergy. Nevertheless, orally- or sublingually-administered food allergens have gained attention and a number of food-allergic children can tolerate gradually increasing amounts of cow's milk and hen's egg. Our purpose is to show that oral desensitisation with food is an allergen-specific therapeutic approach and for this, we describe 4 illustrative children with IgE-mediated food allergy. The first was allergic to cow's milk and hen's egg, the second to cow's milk, hen's egg and fish. Both underwent oral desensitisation to both cow's milk and hen's egg. The third child was allergic to cow's milk, hen's egg and fish and underwent oral desensitisation with cow's milk. The last child was allergic to raw but not to cooked/boiled hen's egg and underwent the oral desensitisation with hen's egg. The first 2 children reached the clinical tolerance to cow's milk after the cow's milk oral desensitisation, but reached the hen's egg tolerance only after the hen's egg oral desensitisation. Moreover, the second child did not tolerate fish after being desensitised to both cow's milk and hen's egg. The third child tolerated cow's milk, but not hen's egg and fish, at the end of the cow's milk oral desensitisation. The fourth child could tolerate the previously not tolerated raw hen's egg after the oral desensitisation with raw hen's egg. In conclusion, we indicate that oral desensitisation with food is allergen specific. The induction of the clinical tolerance to one food is not followed by the tolerance to the other food(s) that the patient is allergic to. To obtain a double or multiple food tolerance, separate desensitisation protocols, one for each food, have to be carried out. Oral desensitisation with food discriminates between raw and cooked proteins.",
keywords = "Cow's milk allergy, Food allergy, Hen 's egg allergy, Oral desensitisation, Therapy for food allergy",
author = "Paolo Meglio and Giampietro, {P. G.} and I. Gabriele and R. Carello and S. Avitabile and E. Galli",
year = "2011",
month = "7",
language = "English",
volume = "24",
pages = "803--811",
journal = "International Journal of Immunopathology and Pharmacology",
issn = "0394-6320",
publisher = "Biomedical Research Press s.a.s.",
number = "3",

}

TY - JOUR

T1 - Oral desensitisation with food is food-specific and protein-specific

AU - Meglio, Paolo

AU - Giampietro, P. G.

AU - Gabriele, I.

AU - Carello, R.

AU - Avitabile, S.

AU - Galli, E.

PY - 2011/7

Y1 - 2011/7

N2 - The avoidance of food(s) is the main therapeutic approach to food allergy. Nevertheless, orally- or sublingually-administered food allergens have gained attention and a number of food-allergic children can tolerate gradually increasing amounts of cow's milk and hen's egg. Our purpose is to show that oral desensitisation with food is an allergen-specific therapeutic approach and for this, we describe 4 illustrative children with IgE-mediated food allergy. The first was allergic to cow's milk and hen's egg, the second to cow's milk, hen's egg and fish. Both underwent oral desensitisation to both cow's milk and hen's egg. The third child was allergic to cow's milk, hen's egg and fish and underwent oral desensitisation with cow's milk. The last child was allergic to raw but not to cooked/boiled hen's egg and underwent the oral desensitisation with hen's egg. The first 2 children reached the clinical tolerance to cow's milk after the cow's milk oral desensitisation, but reached the hen's egg tolerance only after the hen's egg oral desensitisation. Moreover, the second child did not tolerate fish after being desensitised to both cow's milk and hen's egg. The third child tolerated cow's milk, but not hen's egg and fish, at the end of the cow's milk oral desensitisation. The fourth child could tolerate the previously not tolerated raw hen's egg after the oral desensitisation with raw hen's egg. In conclusion, we indicate that oral desensitisation with food is allergen specific. The induction of the clinical tolerance to one food is not followed by the tolerance to the other food(s) that the patient is allergic to. To obtain a double or multiple food tolerance, separate desensitisation protocols, one for each food, have to be carried out. Oral desensitisation with food discriminates between raw and cooked proteins.

AB - The avoidance of food(s) is the main therapeutic approach to food allergy. Nevertheless, orally- or sublingually-administered food allergens have gained attention and a number of food-allergic children can tolerate gradually increasing amounts of cow's milk and hen's egg. Our purpose is to show that oral desensitisation with food is an allergen-specific therapeutic approach and for this, we describe 4 illustrative children with IgE-mediated food allergy. The first was allergic to cow's milk and hen's egg, the second to cow's milk, hen's egg and fish. Both underwent oral desensitisation to both cow's milk and hen's egg. The third child was allergic to cow's milk, hen's egg and fish and underwent oral desensitisation with cow's milk. The last child was allergic to raw but not to cooked/boiled hen's egg and underwent the oral desensitisation with hen's egg. The first 2 children reached the clinical tolerance to cow's milk after the cow's milk oral desensitisation, but reached the hen's egg tolerance only after the hen's egg oral desensitisation. Moreover, the second child did not tolerate fish after being desensitised to both cow's milk and hen's egg. The third child tolerated cow's milk, but not hen's egg and fish, at the end of the cow's milk oral desensitisation. The fourth child could tolerate the previously not tolerated raw hen's egg after the oral desensitisation with raw hen's egg. In conclusion, we indicate that oral desensitisation with food is allergen specific. The induction of the clinical tolerance to one food is not followed by the tolerance to the other food(s) that the patient is allergic to. To obtain a double or multiple food tolerance, separate desensitisation protocols, one for each food, have to be carried out. Oral desensitisation with food discriminates between raw and cooked proteins.

KW - Cow's milk allergy

KW - Food allergy

KW - Hen 's egg allergy

KW - Oral desensitisation

KW - Therapy for food allergy

UR - http://www.scopus.com/inward/record.url?scp=80055113995&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80055113995&partnerID=8YFLogxK

M3 - Article

VL - 24

SP - 803

EP - 811

JO - International Journal of Immunopathology and Pharmacology

JF - International Journal of Immunopathology and Pharmacology

SN - 0394-6320

IS - 3

ER -