Oral fish cartilage polysaccharides in the treatment of photoageing: Biophysical findings

F. Distante, F. Scalise, C. Rona, A. Bonfigli, J. W. Fluhr, Enzo Berardesca

Research output: Contribution to journalArticlepeer-review


The topically applied cosmetic products can be helpful in improving the aged skin condition.The present study shows how oral fish-cartilage food supplementation can be helpful in improving the treatment of ageing skin. A total of 30 healthy women with signs of skin ageing were studied. Fifteen of the women were treated with a food supplement based on polysaccharides derived from the fish cartilage and a natural mix of antioxidants for 2 months and the other 15 with a placebo. Clinical evaluation and biophysical parameters related to skin function and wrinkle severity, such as silicone replica, skin thickness, mechanical properties, skin colour and capacitance, were measured. The results showed statistically significant changes in the active-treated group in comparison to the placebo. In particular, dermal thickness (treatment: from 1.13 to 1.23 mm; P <0.001), skin wrinkling (treatment: from 9.5 to 3.5 Ra; P <0.002), skin colour (treatment: brighter) and less pigmented; P <0.02) and viscoelasticity (treatment: from 0.70 to 0.97%; P <0.02) showed considerable improvement. Most of these parameters are related to changes occurring within the dermal matrix, which is improved after the treatment, whereas most of the topically applied cosmetic products have a short-term effect on superficial structures. A combination treatment (oral and topical) can be more effective in reducing the signs of skin-ageing.

Original languageEnglish
Pages (from-to)81-87
Number of pages7
JournalInternational Journal of Cosmetic Science
Issue number2
Publication statusPublished - 2002


  • Fish cartilage
  • Mechanical properties
  • Skin ageing
  • Skin replica
  • Skin thickness
  • Wrinkles

ASJC Scopus subject areas

  • Chemistry (miscellaneous)
  • Dermatology


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