Oral glucose tolerance test effects on endothelial inflammation markers in healthy subjects and diabetic patients

G. Derosa, A. Dangelo, S. A T Salvadeo, I. Ferrari, E. Fogari, A. Gravina, R. Mereu, I. Palumbo, P. Maffioli, S. Randazzo, A. F G Cicero

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to evaluate the effect of an oral glucose tolerance test (OGTT) on the level of endothelial dysfunction and vascular inflammation markers in healthy subjects (H) and diabetic overweight patients (D). We enrolled 256 healthy subjects and 274 type 2 diabetic patients. We evaluated blood glucose (BG), soluble intercellular adhesion molecule-1 (sICAM-1), interleukin-6 (IL-6), high-sensitivity C reactive protein (hsCRP), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble E-selectin (sE-selectin), and tumor necrosis factor-(TNF-) at baseline and after OGTT. We observed that BG, sICAM-1, IL-6, hs-CRP, sVCAM-1, sE-selectin, and TNF-values were higher in D group than in H group. In a large sample of adult healthy subjects and type 2 diabetics we observed that both answer to an OGTT with a significant increase in biomarkers of systemic low-grade inflammation and endothelial dysfunction such as hsCRP, IL-6, TNF-, sICAM-1, sVCAM-1, and sE-selectin. Type 2 diabetics experienced, however, a more significant increase in TNF-, and sE-selectin.

Original languageEnglish
Pages (from-to)8-13
Number of pages6
JournalHormone and Metabolic Research
Volume42
Issue number1
DOIs
Publication statusPublished - 2010

Keywords

  • Cardiovascular risk
  • Soluble adhesion molecules
  • Type 2 diabetes mellitus
  • Vessels dysfunction

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

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