Abstract
Fifty-one patients presenting a dermatological allergy (erythema, urticaria, angioedema, contact dermatitis) to nickel were treated over 3 years with oral doses of 0.1 kg nickel sulfate per day, following a low-nickel diet. Diagnostic tests comprised patch and oral provocation tests. In 7 cases, the treatment was interrupted because of symptom reactivation, and in 14 cases for other reasons. Among the 30 cases who went through the whole follow-up, symptomatology totally disappeared in 29 cases, and a partial alleviation was achieved in 1 case after 1 year of treatment. Oral provocation tests with these 30 patients showed an overall increase of tolerance. Patch tests showed no variation in 20 cases, a diminution in 5, and were negative in 5. Although the study was not conducted double blind, the results of this attempt to cure nickel allergy are statistically significant.
| Original language | English |
|---|---|
| Pages (from-to) | 251-254 |
| Number of pages | 4 |
| Journal | International Archives of Allergy and Immunology |
| Volume | 107 |
| Issue number | 1-3 |
| DOIs | |
| Publication status | Published - 1995 |
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Keywords
- Hyposensitization
- Nickel allergy
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
Cite this
Oral hyposensitization to nickel allergy : Preliminary clinical results. / Panzani, Raphael C.; Schiavino, D.; Nucera, E.; Pellegrino, S.; Fais, G.; Schinco, G.; Patriarca, G.
In: International Archives of Allergy and Immunology, Vol. 107, No. 1-3, 1995, p. 251-254.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Oral hyposensitization to nickel allergy
T2 - Preliminary clinical results
AU - Panzani, Raphael C.
AU - Schiavino, D.
AU - Nucera, E.
AU - Pellegrino, S.
AU - Fais, G.
AU - Schinco, G.
AU - Patriarca, G.
PY - 1995
Y1 - 1995
N2 - Fifty-one patients presenting a dermatological allergy (erythema, urticaria, angioedema, contact dermatitis) to nickel were treated over 3 years with oral doses of 0.1 kg nickel sulfate per day, following a low-nickel diet. Diagnostic tests comprised patch and oral provocation tests. In 7 cases, the treatment was interrupted because of symptom reactivation, and in 14 cases for other reasons. Among the 30 cases who went through the whole follow-up, symptomatology totally disappeared in 29 cases, and a partial alleviation was achieved in 1 case after 1 year of treatment. Oral provocation tests with these 30 patients showed an overall increase of tolerance. Patch tests showed no variation in 20 cases, a diminution in 5, and were negative in 5. Although the study was not conducted double blind, the results of this attempt to cure nickel allergy are statistically significant.
AB - Fifty-one patients presenting a dermatological allergy (erythema, urticaria, angioedema, contact dermatitis) to nickel were treated over 3 years with oral doses of 0.1 kg nickel sulfate per day, following a low-nickel diet. Diagnostic tests comprised patch and oral provocation tests. In 7 cases, the treatment was interrupted because of symptom reactivation, and in 14 cases for other reasons. Among the 30 cases who went through the whole follow-up, symptomatology totally disappeared in 29 cases, and a partial alleviation was achieved in 1 case after 1 year of treatment. Oral provocation tests with these 30 patients showed an overall increase of tolerance. Patch tests showed no variation in 20 cases, a diminution in 5, and were negative in 5. Although the study was not conducted double blind, the results of this attempt to cure nickel allergy are statistically significant.
KW - Hyposensitization
KW - Nickel allergy
UR - http://www.scopus.com/inward/record.url?scp=0029076540&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029076540&partnerID=8YFLogxK
U2 - 10.1159/000236994
DO - 10.1159/000236994
M3 - Article
VL - 107
SP - 251
EP - 254
JO - International Archives of Allergy and Immunology
JF - International Archives of Allergy and Immunology
SN - 1018-2438
IS - 1-3
ER -