Oral hyposensitization to nickel allergy: Preliminary clinical results

Raphael C. Panzani; D. Schiavino; E. Nucera; S. Pellegrino; G. Fais; G. Schinco; G. Patriarca

doi:10.1159/000236994

Oral hyposensitization to nickel allergy: Preliminary clinical results

Raphael C. Panzani, D. Schiavino, E. Nucera, S. Pellegrino, G. Fais, G. Schinco, G. Patriarca

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article

Abstract

Fifty-one patients presenting a dermatological allergy (erythema, urticaria, angioedema, contact dermatitis) to nickel were treated over 3 years with oral doses of 0.1 kg nickel sulfate per day, following a low-nickel diet. Diagnostic tests comprised patch and oral provocation tests. In 7 cases, the treatment was interrupted because of symptom reactivation, and in 14 cases for other reasons. Among the 30 cases who went through the whole follow-up, symptomatology totally disappeared in 29 cases, and a partial alleviation was achieved in 1 case after 1 year of treatment. Oral provocation tests with these 30 patients showed an overall increase of tolerance. Patch tests showed no variation in 20 cases, a diminution in 5, and were negative in 5. Although the study was not conducted double blind, the results of this attempt to cure nickel allergy are statistically significant.

Original language	English
Pages (from-to)	251-254
Number of pages	4
Journal	International Archives of Allergy and Immunology
Volume	107
Issue number	1-3
DOIs	https://doi.org/10.1159/000236994
Publication status	Published - 1995

Keywords

Hyposensitization
Nickel allergy

ASJC Scopus subject areas

Immunology
Immunology and Allergy

Access to Document

10.1159/000236994

Fingerprint Dive into the research topics of 'Oral hyposensitization to nickel allergy: Preliminary clinical results'. Together they form a unique fingerprint.

Cite this

Panzani, R. C., Schiavino, D., Nucera, E., Pellegrino, S., Fais, G., Schinco, G., & Patriarca, G. (1995). Oral hyposensitization to nickel allergy: Preliminary clinical results. International Archives of Allergy and Immunology, 107(1-3), 251-254. https://doi.org/10.1159/000236994

@article{50b7331c91444e808f96828c355d3f20,

title = "Oral hyposensitization to nickel allergy: Preliminary clinical results",

abstract = "Fifty-one patients presenting a dermatological allergy (erythema, urticaria, angioedema, contact dermatitis) to nickel were treated over 3 years with oral doses of 0.1 kg nickel sulfate per day, following a low-nickel diet. Diagnostic tests comprised patch and oral provocation tests. In 7 cases, the treatment was interrupted because of symptom reactivation, and in 14 cases for other reasons. Among the 30 cases who went through the whole follow-up, symptomatology totally disappeared in 29 cases, and a partial alleviation was achieved in 1 case after 1 year of treatment. Oral provocation tests with these 30 patients showed an overall increase of tolerance. Patch tests showed no variation in 20 cases, a diminution in 5, and were negative in 5. Although the study was not conducted double blind, the results of this attempt to cure nickel allergy are statistically significant.",

keywords = "Hyposensitization, Nickel allergy",

author = "Panzani, {Raphael C.} and D. Schiavino and E. Nucera and S. Pellegrino and G. Fais and G. Schinco and G. Patriarca",

year = "1995",

doi = "10.1159/000236994",

language = "English",

volume = "107",

pages = "251--254",

journal = "International Archives of Allergy and Immunology",

issn = "1018-2438",

publisher = "S. Karger AG",

number = "1-3",

}

TY - JOUR

T1 - Oral hyposensitization to nickel allergy

T2 - Preliminary clinical results

AU - Panzani, Raphael C.

AU - Schiavino, D.

AU - Nucera, E.

AU - Pellegrino, S.

AU - Fais, G.

AU - Schinco, G.

AU - Patriarca, G.

PY - 1995

Y1 - 1995

N2 - Fifty-one patients presenting a dermatological allergy (erythema, urticaria, angioedema, contact dermatitis) to nickel were treated over 3 years with oral doses of 0.1 kg nickel sulfate per day, following a low-nickel diet. Diagnostic tests comprised patch and oral provocation tests. In 7 cases, the treatment was interrupted because of symptom reactivation, and in 14 cases for other reasons. Among the 30 cases who went through the whole follow-up, symptomatology totally disappeared in 29 cases, and a partial alleviation was achieved in 1 case after 1 year of treatment. Oral provocation tests with these 30 patients showed an overall increase of tolerance. Patch tests showed no variation in 20 cases, a diminution in 5, and were negative in 5. Although the study was not conducted double blind, the results of this attempt to cure nickel allergy are statistically significant.

AB - Fifty-one patients presenting a dermatological allergy (erythema, urticaria, angioedema, contact dermatitis) to nickel were treated over 3 years with oral doses of 0.1 kg nickel sulfate per day, following a low-nickel diet. Diagnostic tests comprised patch and oral provocation tests. In 7 cases, the treatment was interrupted because of symptom reactivation, and in 14 cases for other reasons. Among the 30 cases who went through the whole follow-up, symptomatology totally disappeared in 29 cases, and a partial alleviation was achieved in 1 case after 1 year of treatment. Oral provocation tests with these 30 patients showed an overall increase of tolerance. Patch tests showed no variation in 20 cases, a diminution in 5, and were negative in 5. Although the study was not conducted double blind, the results of this attempt to cure nickel allergy are statistically significant.

KW - Hyposensitization

KW - Nickel allergy

UR - http://www.scopus.com/inward/record.url?scp=0029076540&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029076540&partnerID=8YFLogxK

U2 - 10.1159/000236994

DO - 10.1159/000236994

M3 - Article

C2 - 7613144

AN - SCOPUS:0029076540

VL - 107

SP - 251

EP - 254

JO - International Archives of Allergy and Immunology

JF - International Archives of Allergy and Immunology

SN - 1018-2438

IS - 1-3

ER -