Oral lesions in HIV and HCV co-infected individuals in HAART era

Michele Giuliani, Carlo Lajolo, Alessandra Sartorio, Adriana Ammassari, Maria Grazia Lacaita, Michele Scivetti, Enrica Tamburrini, Mario Tumbarello

Research output: Contribution to journalArticlepeer-review


Background: During recent years, a new population of HIV and HCV co-infected subjects has emerged presenting particular oral problems. The aim of our study was to determine the prevalence of oral lesions in HIV+ subjects and HIV and HCV co-infected subjects, to assess whether co-infection is a risk factor for the presence of oral lesions. Methods: 200 HIV+ subjects were consecutively enrolled, divided into two groups: Group 1 (130 HIV+ subjects) and Group 2 (70 HIV-HCV co-infected subjects) and visited by two oral medicine specialists. Epidemiological, laboratory and clinical parameters were gathered to determine the possible risk factors for oral lesions. Results: 52 on 200 subjects (26%) presented oral lesions: in Group 1, 25 on 130 subjects (19.23%) presented oral lesions, whereas in Group 2, 27 on 70 subjects (38.57%) presented oral lesions. Multivariate analysis showed that the following variables are statistically associated with the presence of oral lesions: HIV-HCV co-infection (OR = 2.32; 95% CI = 1.01-5.33: P <0.05) and the use of drugs for the treatment of systemic diseases not associated with HIV (OR = 4.34; 95% CI = 1.78-5.33: P = 0.005). Conclusions: It is possible to assess, on the basis of our results, that co-infected patients are more prone than HIV mono-infected patients to develop oral lesions and thus should undergo strict oral medicine monitoring.

Original languageEnglish
Pages (from-to)468-474
Number of pages7
JournalJournal of Oral Pathology and Medicine
Issue number8
Publication statusPublished - Sep 2008


  • Hepatitis C virus
  • Highly Active Antiretroviral Therapy
  • Human immunodeficiency virus
  • Oral lesions

ASJC Scopus subject areas

  • Cancer Research
  • Pathology and Forensic Medicine
  • Dentistry(all)


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