Oral lichen planus: Update on etiopathogenesis, diagnosis and treatment

Vito Crincoli, Maria Beatrice Di Bisceglie, Michele Scivetti, Alberta Lucchese, Simona Tecco, Felice Festa

Research output: Contribution to journalArticlepeer-review

Abstract

Lichen planus is an inflammatory mucocutaneous disorder. Skin, oral and genital mucosal surfaces, scalp, and nails can be affected. Its development is chronic, with a possible malignant degeneration. Spontaneous remission is rare. Although the etiology of oral lichen planus is still unclear, there is evidence that it is a complex immunologic disease mediated by cytotoxic cells directed against basilar keratinocytes and resulting in vacuolar degeneration and lysis of basal cells. In long-standing, atrophic and erosive forms, the treatment is usually aimed at relieving pain and may include immunosuppressive agents, especially corticosteroid, topical cyclosporin, or tacrolimus, topical and systemic retinoids. However, the use of these drugs may be accompanied by several side effects. For this reason clinicians, currently, have focused their attention to new biological agents which provide selective immunological results with less side effects than generic immunosupressants.

Original languageEnglish
Pages (from-to)11-20
Number of pages10
JournalImmunopharmacology and Immunotoxicology
Volume33
Issue number1
DOIs
Publication statusPublished - Mar 2011

Keywords

  • biologics
  • Lichen planus
  • therapy

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology
  • Toxicology

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