Oral magnesium successfully relieves premenstrual mood changes

Fabio Facchinetti, Paola Borella, Grazia Sances, Loredana Fioroni, Rossell E. Nappi, Andrea R. Genazzani

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

Reduced magnesium (Mg) levels have been reported in women affected by premenstrual syndrome (PMS). To evaluate the effects of an oral Mg preparation on premenstrual symptoms, we studied, by a double-blind, randomized design, 32 women (24–39 years old) with PMS confirmed by the Moos Menstrual Distress Questionnaire. After 2 months of baseline recording, the subjects were randomly assigned to placebo or Mg for two cycles. In the next two cycles, both groups received Mg. Magnesium pyrrolidone carboxylic acid (360 mg Mg) or placebo was administered three times a day, from the 15th day of the menstrual cycle to the onset of menstrual flow. Blood samples for Mg measurement were drawn premenstrually, during the baseline period, and in the second and fourth months of treatment. The Menstrual Distress Questionnaire score of the cluster “pain” was significantly reduced during the second month in both groups, whereas Mg treatment significantly affected both the total Menstrual Distress Questionnaire score and the cluster “negative affect.” In the second month, the women assigned to treatment showed a significant increase in Mg in lymphocytes and polymorphonuclear cells, whereas no changes were observed in plasma and erythrocytes. These data indicate that Mg supplementation could represent an effective treatment of premenstrual symptoms related to mood changes.

Original languageEnglish
Pages (from-to)177-181
Number of pages5
JournalObstetrics and Gynecology
Volume78
Issue number2
Publication statusPublished - 1991

Fingerprint

Magnesium
Premenstrual Syndrome
Placebos
Pyrrolidinones
Therapeutics
Menstrual Cycle
Carboxylic Acids
Erythrocytes
Lymphocytes
Pain

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Facchinetti, F., Borella, P., Sances, G., Fioroni, L., Nappi, R. E., & Genazzani, A. R. (1991). Oral magnesium successfully relieves premenstrual mood changes. Obstetrics and Gynecology, 78(2), 177-181.

Oral magnesium successfully relieves premenstrual mood changes. / Facchinetti, Fabio; Borella, Paola; Sances, Grazia; Fioroni, Loredana; Nappi, Rossell E.; Genazzani, Andrea R.

In: Obstetrics and Gynecology, Vol. 78, No. 2, 1991, p. 177-181.

Research output: Contribution to journalArticle

Facchinetti, F, Borella, P, Sances, G, Fioroni, L, Nappi, RE & Genazzani, AR 1991, 'Oral magnesium successfully relieves premenstrual mood changes', Obstetrics and Gynecology, vol. 78, no. 2, pp. 177-181.
Facchinetti F, Borella P, Sances G, Fioroni L, Nappi RE, Genazzani AR. Oral magnesium successfully relieves premenstrual mood changes. Obstetrics and Gynecology. 1991;78(2):177-181.
Facchinetti, Fabio ; Borella, Paola ; Sances, Grazia ; Fioroni, Loredana ; Nappi, Rossell E. ; Genazzani, Andrea R. / Oral magnesium successfully relieves premenstrual mood changes. In: Obstetrics and Gynecology. 1991 ; Vol. 78, No. 2. pp. 177-181.
@article{ea395f202086419086bc6758394c73a4,
title = "Oral magnesium successfully relieves premenstrual mood changes",
abstract = "Reduced magnesium (Mg) levels have been reported in women affected by premenstrual syndrome (PMS). To evaluate the effects of an oral Mg preparation on premenstrual symptoms, we studied, by a double-blind, randomized design, 32 women (24–39 years old) with PMS confirmed by the Moos Menstrual Distress Questionnaire. After 2 months of baseline recording, the subjects were randomly assigned to placebo or Mg for two cycles. In the next two cycles, both groups received Mg. Magnesium pyrrolidone carboxylic acid (360 mg Mg) or placebo was administered three times a day, from the 15th day of the menstrual cycle to the onset of menstrual flow. Blood samples for Mg measurement were drawn premenstrually, during the baseline period, and in the second and fourth months of treatment. The Menstrual Distress Questionnaire score of the cluster “pain” was significantly reduced during the second month in both groups, whereas Mg treatment significantly affected both the total Menstrual Distress Questionnaire score and the cluster “negative affect.” In the second month, the women assigned to treatment showed a significant increase in Mg in lymphocytes and polymorphonuclear cells, whereas no changes were observed in plasma and erythrocytes. These data indicate that Mg supplementation could represent an effective treatment of premenstrual symptoms related to mood changes.",
author = "Fabio Facchinetti and Paola Borella and Grazia Sances and Loredana Fioroni and Nappi, {Rossell E.} and Genazzani, {Andrea R.}",
year = "1991",
language = "English",
volume = "78",
pages = "177--181",
journal = "Obstetrics and Gynecology",
issn = "0029-7844",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Oral magnesium successfully relieves premenstrual mood changes

AU - Facchinetti, Fabio

AU - Borella, Paola

AU - Sances, Grazia

AU - Fioroni, Loredana

AU - Nappi, Rossell E.

AU - Genazzani, Andrea R.

PY - 1991

Y1 - 1991

N2 - Reduced magnesium (Mg) levels have been reported in women affected by premenstrual syndrome (PMS). To evaluate the effects of an oral Mg preparation on premenstrual symptoms, we studied, by a double-blind, randomized design, 32 women (24–39 years old) with PMS confirmed by the Moos Menstrual Distress Questionnaire. After 2 months of baseline recording, the subjects were randomly assigned to placebo or Mg for two cycles. In the next two cycles, both groups received Mg. Magnesium pyrrolidone carboxylic acid (360 mg Mg) or placebo was administered three times a day, from the 15th day of the menstrual cycle to the onset of menstrual flow. Blood samples for Mg measurement were drawn premenstrually, during the baseline period, and in the second and fourth months of treatment. The Menstrual Distress Questionnaire score of the cluster “pain” was significantly reduced during the second month in both groups, whereas Mg treatment significantly affected both the total Menstrual Distress Questionnaire score and the cluster “negative affect.” In the second month, the women assigned to treatment showed a significant increase in Mg in lymphocytes and polymorphonuclear cells, whereas no changes were observed in plasma and erythrocytes. These data indicate that Mg supplementation could represent an effective treatment of premenstrual symptoms related to mood changes.

AB - Reduced magnesium (Mg) levels have been reported in women affected by premenstrual syndrome (PMS). To evaluate the effects of an oral Mg preparation on premenstrual symptoms, we studied, by a double-blind, randomized design, 32 women (24–39 years old) with PMS confirmed by the Moos Menstrual Distress Questionnaire. After 2 months of baseline recording, the subjects were randomly assigned to placebo or Mg for two cycles. In the next two cycles, both groups received Mg. Magnesium pyrrolidone carboxylic acid (360 mg Mg) or placebo was administered three times a day, from the 15th day of the menstrual cycle to the onset of menstrual flow. Blood samples for Mg measurement were drawn premenstrually, during the baseline period, and in the second and fourth months of treatment. The Menstrual Distress Questionnaire score of the cluster “pain” was significantly reduced during the second month in both groups, whereas Mg treatment significantly affected both the total Menstrual Distress Questionnaire score and the cluster “negative affect.” In the second month, the women assigned to treatment showed a significant increase in Mg in lymphocytes and polymorphonuclear cells, whereas no changes were observed in plasma and erythrocytes. These data indicate that Mg supplementation could represent an effective treatment of premenstrual symptoms related to mood changes.

UR - http://www.scopus.com/inward/record.url?scp=0025835638&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025835638&partnerID=8YFLogxK

M3 - Article

VL - 78

SP - 177

EP - 181

JO - Obstetrics and Gynecology

JF - Obstetrics and Gynecology

SN - 0029-7844

IS - 2

ER -