Abstract
Primary oral malignant melanoma is a rare condition, accounting for 1.3-1.4% of all melanomas, usually presenting with an aggressive clinical behavior. The present study reports the clinicopathological findings of two cases of oral malignant melanoma and discusses the epidemiology, diagnosis and current therapeutic approaches for this uncommon condition. In the first case the patient presented with a pigmented lesion located on the lower mucosal lip. The patient showed no nodal metastases and therefore, underwent a wedge resection. After seven months, the patient presented with neck lymph nodes and multiple visceral metastases. Molecular analysis of BRAF, using a pyrosequencing approach, revealed the presence of BRAF V600E mutation. The patient developed multiple visceral metastases, but refused treatment and was lost to follow-up. In the second case, no BRAF V600E mutation was found, but the patient exhibited a pigmented patch in the lower gingival mucosa, which was excised by surgical treatment. The patient was followed up by an oncologist, but did not undergo an additional therapy and is currently alive with no evidence of visceral metastases at one year following the diagnosis.
| Original language | English |
|---|---|
| Pages (from-to) | 1283-1286 |
| Number of pages | 4 |
| Journal | Oncology Letters |
| Volume | 8 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- BRAF mutations
- Oral malignant melanoma
- Therapeutic approaches
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Oral malignant melanoma : A report of two cases with BRAF molecular analysis. / Soma, Pier Francesco; Pettinato, Angela; Agnone, Anna Maria; Donia, Claudio; Improta, Giuseppina; Fraggetta, Filippo.
In: Oncology Letters, Vol. 8, No. 3, 2014, p. 1283-1286.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Oral malignant melanoma
T2 - A report of two cases with BRAF molecular analysis
AU - Soma, Pier Francesco
AU - Pettinato, Angela
AU - Agnone, Anna Maria
AU - Donia, Claudio
AU - Improta, Giuseppina
AU - Fraggetta, Filippo
PY - 2014
Y1 - 2014
N2 - Primary oral malignant melanoma is a rare condition, accounting for 1.3-1.4% of all melanomas, usually presenting with an aggressive clinical behavior. The present study reports the clinicopathological findings of two cases of oral malignant melanoma and discusses the epidemiology, diagnosis and current therapeutic approaches for this uncommon condition. In the first case the patient presented with a pigmented lesion located on the lower mucosal lip. The patient showed no nodal metastases and therefore, underwent a wedge resection. After seven months, the patient presented with neck lymph nodes and multiple visceral metastases. Molecular analysis of BRAF, using a pyrosequencing approach, revealed the presence of BRAF V600E mutation. The patient developed multiple visceral metastases, but refused treatment and was lost to follow-up. In the second case, no BRAF V600E mutation was found, but the patient exhibited a pigmented patch in the lower gingival mucosa, which was excised by surgical treatment. The patient was followed up by an oncologist, but did not undergo an additional therapy and is currently alive with no evidence of visceral metastases at one year following the diagnosis.
AB - Primary oral malignant melanoma is a rare condition, accounting for 1.3-1.4% of all melanomas, usually presenting with an aggressive clinical behavior. The present study reports the clinicopathological findings of two cases of oral malignant melanoma and discusses the epidemiology, diagnosis and current therapeutic approaches for this uncommon condition. In the first case the patient presented with a pigmented lesion located on the lower mucosal lip. The patient showed no nodal metastases and therefore, underwent a wedge resection. After seven months, the patient presented with neck lymph nodes and multiple visceral metastases. Molecular analysis of BRAF, using a pyrosequencing approach, revealed the presence of BRAF V600E mutation. The patient developed multiple visceral metastases, but refused treatment and was lost to follow-up. In the second case, no BRAF V600E mutation was found, but the patient exhibited a pigmented patch in the lower gingival mucosa, which was excised by surgical treatment. The patient was followed up by an oncologist, but did not undergo an additional therapy and is currently alive with no evidence of visceral metastases at one year following the diagnosis.
KW - BRAF mutations
KW - Oral malignant melanoma
KW - Therapeutic approaches
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UR - http://www.scopus.com/inward/citedby.url?scp=84904257578&partnerID=8YFLogxK
U2 - 10.3892/ol.2014.2314
DO - 10.3892/ol.2014.2314
M3 - Article
AN - SCOPUS:84904257578
VL - 8
SP - 1283
EP - 1286
JO - Oncology Letters
JF - Oncology Letters
SN - 1792-1074
IS - 3
ER -