Oral naloxone antagonizes loperamide-induced delay of orocecal transit

G. Basilisco, G. Camboni, A. Bozzani, M. Paravicini, P. A. Bianchi

Research output: Contribution to journalArticle

Abstract

Orocecal transit time was determined by the lactulose hydrogen breath test in nine healthy volunteers after administration of placebo, loperamide (16 mg per os), and loperamide (16 mg per os) followed by oral naloxone at doses of 16 and 32 mg. The four tests were performed in double-blind conditions and in random sequences. Transit time (mean, sd) after loperamide (128.8 min, 32.9) was significantly increased (P

Original languageEnglish
Pages (from-to)829-832
Number of pages4
JournalDigestive Diseases and Sciences
Volume32
Issue number8
DOIs
Publication statusPublished - Aug 1987

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Keywords

  • hydrogen breath test
  • loperamide
  • naloxone
  • orocecal transit

ASJC Scopus subject areas

  • Gastroenterology

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