Oral naloxone antagonizes loperamide-induced delay of orocecal transit

G. Basilisco, G. Camboni, A. Bozzani, M. Paravicini, P. A. Bianchi

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Orocecal transit time was determined by the lactulose hydrogen breath test in nine healthy volunteers after administration of placebo, loperamide (16 mg per os), and loperamide (16 mg per os) followed by oral naloxone at doses of 16 and 32 mg. The four tests were performed in double-blind conditions and in random sequences. Transit time (mean, sd) after loperamide (128.8 min, 32.9) was significantly increased (P

Original languageEnglish
Pages (from-to)829-832
Number of pages4
JournalDigestive Diseases and Sciences
Volume32
Issue number8
DOIs
Publication statusPublished - Aug 1987

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Loperamide
Naloxone
Lactulose
Breath Tests
Hydrogen
Healthy Volunteers
Placebos

Keywords

  • hydrogen breath test
  • loperamide
  • naloxone
  • orocecal transit

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Oral naloxone antagonizes loperamide-induced delay of orocecal transit. / Basilisco, G.; Camboni, G.; Bozzani, A.; Paravicini, M.; Bianchi, P. A.

In: Digestive Diseases and Sciences, Vol. 32, No. 8, 08.1987, p. 829-832.

Research output: Contribution to journalArticle

Basilisco, G. ; Camboni, G. ; Bozzani, A. ; Paravicini, M. ; Bianchi, P. A. / Oral naloxone antagonizes loperamide-induced delay of orocecal transit. In: Digestive Diseases and Sciences. 1987 ; Vol. 32, No. 8. pp. 829-832.
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