Oral phospholipidic curcumin in juvenile idiopathic arthritis-associated uveitis

Elisabetta Miserocchi, Chiara Giuffrè, Maria Vittoria Cicinelli, Alessandro Marchese, Maurizio Gattinara, Giulio Modorati, Francesco Bandello

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To evaluate the efficacy and the safety of curcumin-phosphatidylcholine complex in children affected by juvenile idiopathic arthritis–associated uveitis as an adjunctive treatment to chronic systemic immunosuppressive therapy. Methods: In this retrospective, longitudinal study, we treated patients affected by juvenile idiopathic arthritis–associated uveitis with residual low-grade inflammatory activity in the anterior chamber with one tablet of curcumin-phosphatidylcholine complex per day, over a year. Low-grade inflammatory activity was characterized by flare 1+ at slit-lamp examination and 10–50 photon counts per ms) at the FC500 laser flare meter. Inactivity of uveitis was defined as complete disappearance of flare at the slit-lamp examination and values <10 ph/ms at laser flare meter. Conversely, recurrence of the uveitis was defined as a one-step increase from baseline in anterior chamber cells levels or laser flare meter measurements >50 ph/ms. Results: A total of 22 out of 27 patients (81%) achieved inactivity at the end of the study. Five patients (19%) did not show a significant reduction in anterior chamber flare, remaining stable throughout the follow-up. Only three episodes of flare-ups in three different patients were recorded. Overall, the treatment was well tolerated by all patients and no ocular discomfort, ocular side effects, or allergic reactions were registered. Conclusion: Adjunctive therapy with curcumin in patients affected by juvenile idiopathic arthritis–associated uveitis improves mild chronic anterior chamber flare and presents a good safety profile. Despite being mild, anterior chamber inflammation should be minimized to avoid the development of sight-threatening complications in these patients.

Original languageEnglish
Pages (from-to)1390-1396
Number of pages7
JournalEuropean Journal of Ophthalmology
Volume30
Issue number6
DOIs
Publication statusPublished - Nov 2020

Keywords

  • Anterior chamber inflammation
  • curcumin
  • juvenile idiopathic arthritis
  • laser flare meter
  • pediatric uveitis

ASJC Scopus subject areas

  • Ophthalmology

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