Terapia steroidea delle epilessie farmacoresistenti: I risultati ottenuti con cicli di prednisone

S. Ricci; M. S. Vari; M. Mancardi; M. P. Baglietto; R. Gaggero

Terapia steroidea delle epilessie farmacoresistenti: I risultati ottenuti con cicli di prednisone

Translated title of the contribution: Oral steroids in childhood intractable epilepsy: Results obtained with prednisone cycles

S. Ricci, M. S. Vari, M. Mancardi, M. P. Baglietto, R. Gaggero

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

Oral steroids besides ACTH, are extensively used in childhood intractable epilepsy, but therapy schedules are variable and the results are not concordant. We present an open study on 20 cases treated in a homogenous way: prednisone from 2 mg/kg/day to 0,5 mg/kg/day for 4-7 mths. The cases were affected overall by CSWS and epileptic encephalopathy. A complete clinical response was obtained in 10 cases, a reduction > 50% in other 8. A remission of EEG abnormalities in 5 and a reduction > 50% in 13. All the moderate side effects observed in 12 cases were reversible. Effectiveness and tolerability of this steroids schedule are confirmed.

Translated title of the contribution	Oral steroids in childhood intractable epilepsy: Results obtained with prednisone cycles
Original language	Italian
Pages (from-to)	257-258
Number of pages	2
Journal	Bollettino - Lega Italiana contro l'Epilessia
Issue number	136-137
Publication status	Published - May 2008

ASJC Scopus subject areas

Clinical Neurology

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title = "Terapia steroidea delle epilessie farmacoresistenti: I risultati ottenuti con cicli di prednisone",

abstract = "Oral steroids besides ACTH, are extensively used in childhood intractable epilepsy, but therapy schedules are variable and the results are not concordant. We present an open study on 20 cases treated in a homogenous way: prednisone from 2 mg/kg/day to 0,5 mg/kg/day for 4-7 mths. The cases were affected overall by CSWS and epileptic encephalopathy. A complete clinical response was obtained in 10 cases, a reduction > 50% in other 8. A remission of EEG abnormalities in 5 and a reduction > 50% in 13. All the moderate side effects observed in 12 cases were reversible. Effectiveness and tolerability of this steroids schedule are confirmed.",

keywords = "CSWS, Epileptic encephalopathy, Steroids",

author = "S. Ricci and Vari, {M. S.} and M. Mancardi and Baglietto, {M. P.} and R. Gaggero",

year = "2008",

month = may,

language = "Italian",

pages = "257--258",

journal = "Bollettino - Lega Italiana contro l'Epilessia",

issn = "0394-560X",

publisher = "Lega Italiana contro l'Epilessia",

number = "136-137",

}

TY - JOUR

T1 - Terapia steroidea delle epilessie farmacoresistenti

T2 - I risultati ottenuti con cicli di prednisone

AU - Ricci, S.

AU - Vari, M. S.

AU - Mancardi, M.

AU - Baglietto, M. P.

AU - Gaggero, R.

PY - 2008/5

Y1 - 2008/5

N2 - Oral steroids besides ACTH, are extensively used in childhood intractable epilepsy, but therapy schedules are variable and the results are not concordant. We present an open study on 20 cases treated in a homogenous way: prednisone from 2 mg/kg/day to 0,5 mg/kg/day for 4-7 mths. The cases were affected overall by CSWS and epileptic encephalopathy. A complete clinical response was obtained in 10 cases, a reduction > 50% in other 8. A remission of EEG abnormalities in 5 and a reduction > 50% in 13. All the moderate side effects observed in 12 cases were reversible. Effectiveness and tolerability of this steroids schedule are confirmed.

AB - Oral steroids besides ACTH, are extensively used in childhood intractable epilepsy, but therapy schedules are variable and the results are not concordant. We present an open study on 20 cases treated in a homogenous way: prednisone from 2 mg/kg/day to 0,5 mg/kg/day for 4-7 mths. The cases were affected overall by CSWS and epileptic encephalopathy. A complete clinical response was obtained in 10 cases, a reduction > 50% in other 8. A remission of EEG abnormalities in 5 and a reduction > 50% in 13. All the moderate side effects observed in 12 cases were reversible. Effectiveness and tolerability of this steroids schedule are confirmed.

KW - CSWS

KW - Epileptic encephalopathy

KW - Steroids

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AN - SCOPUS:51849161263

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JO - Bollettino - Lega Italiana contro l'Epilessia

JF - Bollettino - Lega Italiana contro l'Epilessia

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