Abstract
Oral steroids besides ACTH, are extensively used in childhood intractable epilepsy, but therapy schedules are variable and the results are not concordant. We present an open study on 20 cases treated in a homogenous way: prednisone from 2 mg/kg/day to 0,5 mg/kg/day for 4-7 mths. The cases were affected overall by CSWS and epileptic encephalopathy. A complete clinical response was obtained in 10 cases, a reduction > 50% in other 8. A remission of EEG abnormalities in 5 and a reduction > 50% in 13. All the moderate side effects observed in 12 cases were reversible. Effectiveness and tolerability of this steroids schedule are confirmed.
| Original language | Italian |
|---|---|
| Pages (from-to) | 257-258 |
| Number of pages | 2 |
| Journal | Bollettino - Lega Italiana contro l'Epilessia |
| Issue number | 136-137 |
| Publication status | Published - May 2008 |
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ASJC Scopus subject areas
- Clinical Neurology
Cite this
Terapia steroidea delle epilessie farmacoresistenti : I risultati ottenuti con cicli di prednisone. / Ricci, S.; Vari, M. S.; Mancardi, M.; Baglietto, M. P.; Gaggero, R.
In: Bollettino - Lega Italiana contro l'Epilessia, No. 136-137, 05.2008, p. 257-258.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Terapia steroidea delle epilessie farmacoresistenti
T2 - I risultati ottenuti con cicli di prednisone
AU - Ricci, S.
AU - Vari, M. S.
AU - Mancardi, M.
AU - Baglietto, M. P.
AU - Gaggero, R.
PY - 2008/5
Y1 - 2008/5
N2 - Oral steroids besides ACTH, are extensively used in childhood intractable epilepsy, but therapy schedules are variable and the results are not concordant. We present an open study on 20 cases treated in a homogenous way: prednisone from 2 mg/kg/day to 0,5 mg/kg/day for 4-7 mths. The cases were affected overall by CSWS and epileptic encephalopathy. A complete clinical response was obtained in 10 cases, a reduction > 50% in other 8. A remission of EEG abnormalities in 5 and a reduction > 50% in 13. All the moderate side effects observed in 12 cases were reversible. Effectiveness and tolerability of this steroids schedule are confirmed.
AB - Oral steroids besides ACTH, are extensively used in childhood intractable epilepsy, but therapy schedules are variable and the results are not concordant. We present an open study on 20 cases treated in a homogenous way: prednisone from 2 mg/kg/day to 0,5 mg/kg/day for 4-7 mths. The cases were affected overall by CSWS and epileptic encephalopathy. A complete clinical response was obtained in 10 cases, a reduction > 50% in other 8. A remission of EEG abnormalities in 5 and a reduction > 50% in 13. All the moderate side effects observed in 12 cases were reversible. Effectiveness and tolerability of this steroids schedule are confirmed.
KW - CSWS
KW - Epileptic encephalopathy
KW - Steroids
UR - http://www.scopus.com/inward/record.url?scp=51849161263&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=51849161263&partnerID=8YFLogxK
M3 - Articolo
AN - SCOPUS:51849161263
SP - 257
EP - 258
JO - Bollettino - Lega Italiana contro l'Epilessia
JF - Bollettino - Lega Italiana contro l'Epilessia
SN - 0394-560X
IS - 136-137
ER -