Oral supplementation with sucrosomial ferric pyrophosphate plus l-ascorbic acid to ameliorate the martial status: A randomized controlled trial

Matteo Briguglio, Silvana Hrelia, Marco Malaguti, Elena De Vecchi, Giovanni Lombardi, Giuseppe Banfi, Patrizia Riso, Marisa Porrini, Sergio Romagnoli, Fabio Pino, Tiziano Crespi, Paolo Perazzo

Research output: Contribution to journalArticlepeer-review

Abstract

Altered martial indices before orthopedic surgery are associated with higher rates of complications and greatly affect the patient’s functional ability. Oral supplements can optimize the preoperative martial status, with clinical efficacy and the patient’s tolerability being highly dependent on the pharmaceutical formula. Patients undergoing elective hip/knee arthroplasty were randomized to be supplemented with a 30-day oral therapy of sucrosomial ferric pyrophosphate plus L-ascorbic acid. The tolerability was 2.7% among treated patients. Adjustments for confounding factors, such as iron absorption influencers, showed a relevant response limited to older patients (≥ 65 years old), whose uncharacterized Hb loss was averted upon treatment with iron formula. Older patients with no support lost −2.8 ± 5.1%, while the intervention group gained +0.7 ± 4.6% of circulating hemoglobin from baseline (p = 0.019). Gastrointestinal diseases, medications, and possible dietary factors could affect the efficacy of iron supplements. Future opportunities may consider to couple ferric pyrophosphate with other nutrients, to pay attention in avoiding absorption disruptors, or to implement interventions to obtain an earlier martial status optimization at the population level.

Original languageEnglish
Article number386
JournalNutrients
Volume12
Issue number2
DOIs
Publication statusPublished - Feb 2020

Keywords

  • Anemia
  • Dietary supplements
  • Frail
  • Functional food
  • Integrative medicine
  • Iron
  • Musculoskeletal diseases
  • Nutraceutical
  • Older adult
  • Orthopedics
  • Vitamin

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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