Abstract
Airway inflammation is a key process involved in asthma since mediators released by inflammatory cells may induce acute damages and structural changes to the airways. Airway inflammation is, therefore, a primary therapeutic goal and the treatment with anti-inflammatory drugs should be started as early as possible in order to avoid irreversible airway remodelling occurring during chronic inflammation, even in young children. The need to monitor inflammation has led to the exploration of volatile compound in exhaled air. Nitric oxide (NO) is being increasingly used to assess airway inflammation in childhood. Moreover, it has become clear in the last few years that increased NO is present in the expired air of patients with asthma and that measurement of the fractional concentration of exhaled NO (FENO) may represent a non invasive, simple, well tolerated test thought to reflect the airway inflammatory events in asthmatic children.
| Original language | English |
|---|---|
| Pages (from-to) | 233-244 |
| Number of pages | 12 |
| Journal | Minerva Pneumologica |
| Volume | 42 |
| Issue number | 4 |
| Publication status | Published - Dec 2003 |
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Keywords
- Asthma
- Child
- Inflammation
- Nitric oxide
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Orally exhaled nitric oxide as a marker of inflammation in childhood asthma. / Silvestri, M.; Sabatini, F.; Serpero, L.; Petecchia, L.; Rossi, G. A.
In: Minerva Pneumologica, Vol. 42, No. 4, 12.2003, p. 233-244.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Orally exhaled nitric oxide as a marker of inflammation in childhood asthma
AU - Silvestri, M.
AU - Sabatini, F.
AU - Serpero, L.
AU - Petecchia, L.
AU - Rossi, G. A.
PY - 2003/12
Y1 - 2003/12
N2 - Airway inflammation is a key process involved in asthma since mediators released by inflammatory cells may induce acute damages and structural changes to the airways. Airway inflammation is, therefore, a primary therapeutic goal and the treatment with anti-inflammatory drugs should be started as early as possible in order to avoid irreversible airway remodelling occurring during chronic inflammation, even in young children. The need to monitor inflammation has led to the exploration of volatile compound in exhaled air. Nitric oxide (NO) is being increasingly used to assess airway inflammation in childhood. Moreover, it has become clear in the last few years that increased NO is present in the expired air of patients with asthma and that measurement of the fractional concentration of exhaled NO (FENO) may represent a non invasive, simple, well tolerated test thought to reflect the airway inflammatory events in asthmatic children.
AB - Airway inflammation is a key process involved in asthma since mediators released by inflammatory cells may induce acute damages and structural changes to the airways. Airway inflammation is, therefore, a primary therapeutic goal and the treatment with anti-inflammatory drugs should be started as early as possible in order to avoid irreversible airway remodelling occurring during chronic inflammation, even in young children. The need to monitor inflammation has led to the exploration of volatile compound in exhaled air. Nitric oxide (NO) is being increasingly used to assess airway inflammation in childhood. Moreover, it has become clear in the last few years that increased NO is present in the expired air of patients with asthma and that measurement of the fractional concentration of exhaled NO (FENO) may represent a non invasive, simple, well tolerated test thought to reflect the airway inflammatory events in asthmatic children.
KW - Asthma
KW - Child
KW - Inflammation
KW - Nitric oxide
UR - http://www.scopus.com/inward/record.url?scp=1542319900&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1542319900&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:1542319900
VL - 42
SP - 233
EP - 244
JO - Minerva Pneumologica
JF - Minerva Pneumologica
SN - 0026-4954
IS - 4
ER -