Orbital metastasis as a first indication of prostate cancer: A case report

Riccardo Autorino, Aniello Zito, Ferdinando Di Giacomo, Luca Cosentino, Giuseppe Quarto, Giuseppe Di Lorenzo, Salvatore Mordente, Umberto Pane, Antonio Giordano, Massimo D'Armiento

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Prostatic carcinoma accounts for only 3.6% of orbital metastases encountered in clinical practice. We report the clinical presentation and response to treatment of a patient with metastatic prostatic carcinoma to the sella turcica. A 73-year-old man presented with a three-months history of progressive right proptosis associated with increasing diplopia in downgaze and slightly decreased visual acuity. Gadiolinium-MRI scans of the head revealed a left osteoblastic intrasellar mass, displacing the pituitary gland. Laboratory testing revealed a serum PSA level of 22 ng/ml. Transrectal ultrasound-guided biopsy revealed prostatic adenocarcinoma (Gleason score 4+3) in both lobes of the prostate. A bone scan was performed showing that the patient had multiple secondary bony lesions. Total androgen blockade was initiated. Moreover, he was referred for radiotherapy of this metastatic lesion to the sella turcica. The visual complaints regressed dramatically within the first month of the treatment. A follow-up MRI scan at 6 months showed almost complete involution of the orbital metastatic process. However the disease subsequently progressed and the patient died 22 months after diagnosis.

Original languageEnglish
Pages (from-to)109-110
Number of pages2
JournalArchivio Italiano di Urologia e Andrologia
Volume77
Issue number2
Publication statusPublished - Jun 2005

Fingerprint

Sella Turcica
Prostatic Neoplasms
Neoplasm Metastasis
Magnetic Resonance Imaging
Carcinoma
Exophthalmos
Diplopia
Neoplasm Grading
Pituitary Gland
Androgens
Visual Acuity
Prostate
Adenocarcinoma
Radiotherapy
Head
Biopsy
Bone and Bones
Therapeutics
Serum

Keywords

  • Metastatic prostate cancer
  • Orbital metastases
  • Sella turcica
  • Treatment

ASJC Scopus subject areas

  • Nephrology
  • Urology

Cite this

Autorino, R., Zito, A., Di Giacomo, F., Cosentino, L., Quarto, G., Di Lorenzo, G., ... D'Armiento, M. (2005). Orbital metastasis as a first indication of prostate cancer: A case report. Archivio Italiano di Urologia e Andrologia, 77(2), 109-110.

Orbital metastasis as a first indication of prostate cancer : A case report. / Autorino, Riccardo; Zito, Aniello; Di Giacomo, Ferdinando; Cosentino, Luca; Quarto, Giuseppe; Di Lorenzo, Giuseppe; Mordente, Salvatore; Pane, Umberto; Giordano, Antonio; D'Armiento, Massimo.

In: Archivio Italiano di Urologia e Andrologia, Vol. 77, No. 2, 06.2005, p. 109-110.

Research output: Contribution to journalArticle

Autorino, R, Zito, A, Di Giacomo, F, Cosentino, L, Quarto, G, Di Lorenzo, G, Mordente, S, Pane, U, Giordano, A & D'Armiento, M 2005, 'Orbital metastasis as a first indication of prostate cancer: A case report', Archivio Italiano di Urologia e Andrologia, vol. 77, no. 2, pp. 109-110.
Autorino R, Zito A, Di Giacomo F, Cosentino L, Quarto G, Di Lorenzo G et al. Orbital metastasis as a first indication of prostate cancer: A case report. Archivio Italiano di Urologia e Andrologia. 2005 Jun;77(2):109-110.
Autorino, Riccardo ; Zito, Aniello ; Di Giacomo, Ferdinando ; Cosentino, Luca ; Quarto, Giuseppe ; Di Lorenzo, Giuseppe ; Mordente, Salvatore ; Pane, Umberto ; Giordano, Antonio ; D'Armiento, Massimo. / Orbital metastasis as a first indication of prostate cancer : A case report. In: Archivio Italiano di Urologia e Andrologia. 2005 ; Vol. 77, No. 2. pp. 109-110.
@article{4dafa7a2e7394943bd4fc793be6af795,
title = "Orbital metastasis as a first indication of prostate cancer: A case report",
abstract = "Prostatic carcinoma accounts for only 3.6{\%} of orbital metastases encountered in clinical practice. We report the clinical presentation and response to treatment of a patient with metastatic prostatic carcinoma to the sella turcica. A 73-year-old man presented with a three-months history of progressive right proptosis associated with increasing diplopia in downgaze and slightly decreased visual acuity. Gadiolinium-MRI scans of the head revealed a left osteoblastic intrasellar mass, displacing the pituitary gland. Laboratory testing revealed a serum PSA level of 22 ng/ml. Transrectal ultrasound-guided biopsy revealed prostatic adenocarcinoma (Gleason score 4+3) in both lobes of the prostate. A bone scan was performed showing that the patient had multiple secondary bony lesions. Total androgen blockade was initiated. Moreover, he was referred for radiotherapy of this metastatic lesion to the sella turcica. The visual complaints regressed dramatically within the first month of the treatment. A follow-up MRI scan at 6 months showed almost complete involution of the orbital metastatic process. However the disease subsequently progressed and the patient died 22 months after diagnosis.",
keywords = "Metastatic prostate cancer, Orbital metastases, Sella turcica, Treatment",
author = "Riccardo Autorino and Aniello Zito and {Di Giacomo}, Ferdinando and Luca Cosentino and Giuseppe Quarto and {Di Lorenzo}, Giuseppe and Salvatore Mordente and Umberto Pane and Antonio Giordano and Massimo D'Armiento",
year = "2005",
month = "6",
language = "English",
volume = "77",
pages = "109--110",
journal = "Archivio Italiano di Urologia Nefrologia Andrologia",
issn = "1120-8538",
publisher = "Edizioni Scripta Manent s.n.c.",
number = "2",

}

TY - JOUR

T1 - Orbital metastasis as a first indication of prostate cancer

T2 - A case report

AU - Autorino, Riccardo

AU - Zito, Aniello

AU - Di Giacomo, Ferdinando

AU - Cosentino, Luca

AU - Quarto, Giuseppe

AU - Di Lorenzo, Giuseppe

AU - Mordente, Salvatore

AU - Pane, Umberto

AU - Giordano, Antonio

AU - D'Armiento, Massimo

PY - 2005/6

Y1 - 2005/6

N2 - Prostatic carcinoma accounts for only 3.6% of orbital metastases encountered in clinical practice. We report the clinical presentation and response to treatment of a patient with metastatic prostatic carcinoma to the sella turcica. A 73-year-old man presented with a three-months history of progressive right proptosis associated with increasing diplopia in downgaze and slightly decreased visual acuity. Gadiolinium-MRI scans of the head revealed a left osteoblastic intrasellar mass, displacing the pituitary gland. Laboratory testing revealed a serum PSA level of 22 ng/ml. Transrectal ultrasound-guided biopsy revealed prostatic adenocarcinoma (Gleason score 4+3) in both lobes of the prostate. A bone scan was performed showing that the patient had multiple secondary bony lesions. Total androgen blockade was initiated. Moreover, he was referred for radiotherapy of this metastatic lesion to the sella turcica. The visual complaints regressed dramatically within the first month of the treatment. A follow-up MRI scan at 6 months showed almost complete involution of the orbital metastatic process. However the disease subsequently progressed and the patient died 22 months after diagnosis.

AB - Prostatic carcinoma accounts for only 3.6% of orbital metastases encountered in clinical practice. We report the clinical presentation and response to treatment of a patient with metastatic prostatic carcinoma to the sella turcica. A 73-year-old man presented with a three-months history of progressive right proptosis associated with increasing diplopia in downgaze and slightly decreased visual acuity. Gadiolinium-MRI scans of the head revealed a left osteoblastic intrasellar mass, displacing the pituitary gland. Laboratory testing revealed a serum PSA level of 22 ng/ml. Transrectal ultrasound-guided biopsy revealed prostatic adenocarcinoma (Gleason score 4+3) in both lobes of the prostate. A bone scan was performed showing that the patient had multiple secondary bony lesions. Total androgen blockade was initiated. Moreover, he was referred for radiotherapy of this metastatic lesion to the sella turcica. The visual complaints regressed dramatically within the first month of the treatment. A follow-up MRI scan at 6 months showed almost complete involution of the orbital metastatic process. However the disease subsequently progressed and the patient died 22 months after diagnosis.

KW - Metastatic prostate cancer

KW - Orbital metastases

KW - Sella turcica

KW - Treatment

UR - http://www.scopus.com/inward/record.url?scp=22644444707&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22644444707&partnerID=8YFLogxK

M3 - Article

C2 - 16146273

AN - SCOPUS:22644444707

VL - 77

SP - 109

EP - 110

JO - Archivio Italiano di Urologia Nefrologia Andrologia

JF - Archivio Italiano di Urologia Nefrologia Andrologia

SN - 1120-8538

IS - 2

ER -