Orchestration of lymphocyte chemotaxis by mitochondrial dynamics

Silvia Campello, Rosa Ana Lacalle, Monica Bettella, Santos Mañes, Luca Scorrano, Antonella Viola

Research output: Contribution to journalArticle

Abstract

Lymphocyte traffic is required to maintain homeostasis and perform appropriate immunological reactions. To migrate into inflamed tissues, lymphocytes must acquire spatial and functional asymmetries. Mitochondria are highly dynamic organelles that distribute in the cytoplasm to meet specific cellular needs, but whether this is essential to lymphocyte functions is unknown. We show that mitochondria specifically concentrate at the uropod during lymphocyte migration by a process involving rearrangements of their shape. Mitochondrial fission facilitates relocation of the organelles and promotes lymphocyte chemotaxis, whereas mitochondrial fusion inhibits both processes. Our data substantiate a new role for mitochondrial dynamics and suggest that mitochondria redistribution is required to regulate the motor of migrating cells. JEM

Original languageEnglish
Pages (from-to)2879-2886
Number of pages8
JournalJournal of Experimental Medicine
Volume203
Issue number13
DOIs
Publication statusPublished - Dec 25 2006

ASJC Scopus subject areas

  • Immunology

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    Campello, S., Lacalle, R. A., Bettella, M., Mañes, S., Scorrano, L., & Viola, A. (2006). Orchestration of lymphocyte chemotaxis by mitochondrial dynamics. Journal of Experimental Medicine, 203(13), 2879-2886. https://doi.org/10.1084/jem.20061877