Ordering quantiles through confidence statements

Cassio P. de Campos, Carlos A de B Pereira, Paola M V Rancoita, Adriano Polpo

Research output: Contribution to journalArticle

Abstract

Ranking variables according to their relevance to predict an outcome is an important task in biomedicine. For instance, such ranking can be used for selecting a smaller number of genes for then applying other sophisticated experiments only on genes identified as important. A nonparametric method called Quor is designed to provide a confidence value for the order of arbitrary quantiles of different populations using independent samples. This confidence may provide insights about possible differences among groups and yields a ranking of importance for the variables. Computations are efficient and use exact distributions with no need for asymptotic considerations. Experiments with simulated data and with multiple real -omics data sets are performed, and they show advantages and disadvantages of the method. Quor has no assumptions but independence of samples, thus it might be a better option when assumptions of other methods cannot be asserted. The software is publicly available on CRAN.

Original languageEnglish
Article number357
JournalEntropy
Volume18
Issue number10
DOIs
Publication statusPublished - 2016

Keywords

  • Genomics
  • Median order
  • Nonparametric
  • Quantiles
  • Significance index

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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    de Campos, C. P., Pereira, C. A. D. B., Rancoita, P. M. V., & Polpo, A. (2016). Ordering quantiles through confidence statements. Entropy, 18(10), [357]. https://doi.org/10.3390/e18100357