Organ protection by volatile anesthetics in non-coronary artery bypass grafting surgery

Giovanni Landoni, Stefano Turi, Elena Bignami, Alberto Zangrillo

Research output: Contribution to journalArticle

Abstract

The cardioprotective properties of volatile anesthetics have been widely demonstrated by numerous randomized studies and meta-analyses in the setting of cardiac surgery, above of all during coronary artery bypass grafting procedures. Recently, conflicting results have been presented in cardiac non-coronary artery bypass grafting surgery. Unfortunately, despite the existence of a great number of studies comparing a total intravenous anesthetic regimen with an inhalational regimen, at present there are no randomized studies presenting data regarding mortality and important outcomes, such as myocardial infarction, in non-cardiac surgery. In this review we analyze and present the results of the most recent and important studies regarding anesthetic preconditioning in cardiac and in noncardiac surgery. Furthermore, we focus on the emerging data from animal experiments, discussing in particular the molecular mechanisms underlying anesthetic preconditioning.

Original languageEnglish
Pages (from-to)589-603
Number of pages15
JournalFuture Cardiology
Volume5
Issue number6
DOIs
Publication statusPublished - 2009

Keywords

  • Cardiac anesthesia
  • Cardioprotection
  • Myocardial infarction
  • Preconditioning
  • Volatile anesthetics

ASJC Scopus subject areas

  • Molecular Medicine
  • Cardiology and Cardiovascular Medicine

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