Organ protection by volatile anesthetics in non-coronary artery bypass grafting surgery

Research output: Contribution to journalArticle

Abstract

The cardioprotective properties of volatile anesthetics have been widely demonstrated by numerous randomized studies and meta-analyses in the setting of cardiac surgery, above of all during coronary artery bypass grafting procedures. Recently, conflicting results have been presented in cardiac non-coronary artery bypass grafting surgery. Unfortunately, despite the existence of a great number of studies comparing a total intravenous anesthetic regimen with an inhalational regimen, at present there are no randomized studies presenting data regarding mortality and important outcomes, such as myocardial infarction, in non-cardiac surgery. In this review we analyze and present the results of the most recent and important studies regarding anesthetic preconditioning in cardiac and in noncardiac surgery. Furthermore, we focus on the emerging data from animal experiments, discussing in particular the molecular mechanisms underlying anesthetic preconditioning.

Original languageEnglish
Pages (from-to)589-603
Number of pages15
JournalFuture Cardiology
Volume5
Issue number6
DOIs
Publication statusPublished - 2009

Fingerprint

Anesthetics
Arteries
Intravenous Anesthetics
Coronary Artery Bypass
Thoracic Surgery
Meta-Analysis
Myocardial Infarction
Mortality

Keywords

  • Cardiac anesthesia
  • Cardioprotection
  • Myocardial infarction
  • Preconditioning
  • Volatile anesthetics

ASJC Scopus subject areas

  • Molecular Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Organ protection by volatile anesthetics in non-coronary artery bypass grafting surgery. / Landoni, Giovanni; Turi, Stefano; Bignami, Elena; Zangrillo, Alberto.

In: Future Cardiology, Vol. 5, No. 6, 2009, p. 589-603.

Research output: Contribution to journalArticle

@article{a5a11aef868b4d11a1a4f208b57718f9,
title = "Organ protection by volatile anesthetics in non-coronary artery bypass grafting surgery",
abstract = "The cardioprotective properties of volatile anesthetics have been widely demonstrated by numerous randomized studies and meta-analyses in the setting of cardiac surgery, above of all during coronary artery bypass grafting procedures. Recently, conflicting results have been presented in cardiac non-coronary artery bypass grafting surgery. Unfortunately, despite the existence of a great number of studies comparing a total intravenous anesthetic regimen with an inhalational regimen, at present there are no randomized studies presenting data regarding mortality and important outcomes, such as myocardial infarction, in non-cardiac surgery. In this review we analyze and present the results of the most recent and important studies regarding anesthetic preconditioning in cardiac and in noncardiac surgery. Furthermore, we focus on the emerging data from animal experiments, discussing in particular the molecular mechanisms underlying anesthetic preconditioning.",
keywords = "Cardiac anesthesia, Cardioprotection, Myocardial infarction, Preconditioning, Volatile anesthetics",
author = "Giovanni Landoni and Stefano Turi and Elena Bignami and Alberto Zangrillo",
year = "2009",
doi = "10.2217/fca.09.52",
language = "English",
volume = "5",
pages = "589--603",
journal = "Future Cardiology",
issn = "1479-6678",
publisher = "Future Medicine Ltd.",
number = "6",

}

TY - JOUR

T1 - Organ protection by volatile anesthetics in non-coronary artery bypass grafting surgery

AU - Landoni, Giovanni

AU - Turi, Stefano

AU - Bignami, Elena

AU - Zangrillo, Alberto

PY - 2009

Y1 - 2009

N2 - The cardioprotective properties of volatile anesthetics have been widely demonstrated by numerous randomized studies and meta-analyses in the setting of cardiac surgery, above of all during coronary artery bypass grafting procedures. Recently, conflicting results have been presented in cardiac non-coronary artery bypass grafting surgery. Unfortunately, despite the existence of a great number of studies comparing a total intravenous anesthetic regimen with an inhalational regimen, at present there are no randomized studies presenting data regarding mortality and important outcomes, such as myocardial infarction, in non-cardiac surgery. In this review we analyze and present the results of the most recent and important studies regarding anesthetic preconditioning in cardiac and in noncardiac surgery. Furthermore, we focus on the emerging data from animal experiments, discussing in particular the molecular mechanisms underlying anesthetic preconditioning.

AB - The cardioprotective properties of volatile anesthetics have been widely demonstrated by numerous randomized studies and meta-analyses in the setting of cardiac surgery, above of all during coronary artery bypass grafting procedures. Recently, conflicting results have been presented in cardiac non-coronary artery bypass grafting surgery. Unfortunately, despite the existence of a great number of studies comparing a total intravenous anesthetic regimen with an inhalational regimen, at present there are no randomized studies presenting data regarding mortality and important outcomes, such as myocardial infarction, in non-cardiac surgery. In this review we analyze and present the results of the most recent and important studies regarding anesthetic preconditioning in cardiac and in noncardiac surgery. Furthermore, we focus on the emerging data from animal experiments, discussing in particular the molecular mechanisms underlying anesthetic preconditioning.

KW - Cardiac anesthesia

KW - Cardioprotection

KW - Myocardial infarction

KW - Preconditioning

KW - Volatile anesthetics

UR - http://www.scopus.com/inward/record.url?scp=74049117085&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=74049117085&partnerID=8YFLogxK

U2 - 10.2217/fca.09.52

DO - 10.2217/fca.09.52

M3 - Article

C2 - 19886786

AN - SCOPUS:74049117085

VL - 5

SP - 589

EP - 603

JO - Future Cardiology

JF - Future Cardiology

SN - 1479-6678

IS - 6

ER -