Organ transplantation from "increased infectious risk donors"

the experience of the Nord Italia Transplant program - A retrospective study

Paolo Antonio Grossi, Daniela Dalla Gasperina, Domenico Lombardi, Andrea Ricci, Giuseppe Piccolo, Alessandro Nanni Costa

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to assess the safety and the clinical outcome associated with organ transplantation from increased infectious risk donors (IRD). We retrospectively identified all adult deceased IRD referred to the Nord Italia Transplant program coordinating center from November 2006 to November 2011. All potential donors were screened for social risk factors that may increase the risk of donor-derived infection with human immunodeficiency (HIV), hepatitis B virus (HBV), or hepatitis C virus (HCV). All recipients were followed monthly for the first 6 months post-transplant. A total of 86 potential IRD were identified during the study period. Three hundred and seventy-nine organs from IRD were offered to the transplant centers, but only 185 (48.8%) were used for transplantation. Organs from IRD were transplanted into 174 recipients. The complete follow-up data were available for 152 of 174 (87.3%) recipients. During a mean follow-up of 11.7 months (median 12; range 2.4-12), no transmission of HIV, HBV, or syphilis was documented by serology and nucleic acid testing (NAT) testing. Two patients transplanted with organs from HCV-RNA-positive donors, as expected, developed post-transplant HCV infection. In conclusion, the use of organs from IRD was associated with a safe increase in the transplant procedures in our country.

Original languageEnglish
Pages (from-to)212-219
Number of pages8
JournalTransplant International
Volume31
Issue number2
DOIs
Publication statusPublished - Feb 2018

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Organ Transplantation
Retrospective Studies
Tissue Donors
Transplants
Hepacivirus
Hepatitis B virus
HIV
Virus Diseases
Serology
Syphilis
Nucleic Acids
Transplantation
RNA
Safety
Infection

Keywords

  • expanded donor pool
  • hepatitis C
  • increased infectious risk donors
  • Infection
  • Organ Transplantation

Cite this

Organ transplantation from "increased infectious risk donors" : the experience of the Nord Italia Transplant program - A retrospective study. / Grossi, Paolo Antonio; Dalla Gasperina, Daniela; Lombardi, Domenico; Ricci, Andrea; Piccolo, Giuseppe; Nanni Costa, Alessandro.

In: Transplant International, Vol. 31, No. 2, 02.2018, p. 212-219.

Research output: Contribution to journalArticle

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