Organ Transplantation From Nonstandard Risk Donors: Midway Between Rigid and Flexible Rules

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In order to bridge the gap between available organs and patients needing transplants, donor selection criteria for donors are increasingly being extended; the possibility of using organs from nonstandard risk donors has been introduced in many countries. This clearly poses considerable ethical issues that should be analyzed and taken into consideration by the competent bodies and institutions. In this article, we illustrate the Italian situation regarding the possibility of using organs from anti-hepatitis C virus (HCV) and HCV RNA-positive donors (anti-HCV+ve) in negative recipients (healthy subjects who have never come into contact with the hepatitis C virus) in light of the availability of new direct-acting antiviral drugs (DAAs) for hepatitis C treatment. We discuss the motivations behind the both favorable opinions of the Ethics Committee of the Italian National Institute of Health (Istituto Superiore di Sanità) and the Italian National Bioethics Committee (Comitato Nazionale per la Bioetica) discussing the main implications from an ethical point of view.

Original languageEnglish
Pages (from-to)2856-2859
Number of pages4
JournalTransplantation Proceedings
Issue number9
Publication statusPublished - Nov 2019


  • Antiviral Agents/therapeutic use
  • Donor Selection/standards
  • Hepacivirus/immunology
  • Hepatitis C/prevention & control
  • Humans
  • Italy
  • Tissue Donors/supply & distribution
  • Transplants/supply & distribution


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