Organelle rearrangement in the maturing oocyte

Lucia De Santis, Tiziana A L Brevini

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Mammalian oocytes acquire a series of competencies during follicular development that play critical roles at fertilization and subsequent stages of preimplantation embryonic development. Before the mammalian oocyte engages in the fertilization process, it must acquire an array of molecular and cellular assets defining its developmental potential. These properties specify competencies to complete meiosis and initiate mitosis. Meiotic maturation requires the acquisition both of nuclear and cytoplasmic competence and this complex mechanism involves most of the organelles, the cytoskeleton and molecules that are relocated from the nucleus to the cytoplasm. Messenger RNAs of maternal origin are accumulated in the oocyte throughout its growth in the ovary. These transcripts are then shuttled to specific sites of the ooplasm, where local translation is promoted. The nucleus as an organelle undergoes significant positional rearrangements during maturation. At the same time, the spindle changes its localization drifting from the cortical region to the centre of the oocyte and then back cortically. The endoplasmic reticulum undergoes significant changes during maturation in its distribution that reflect an enhanced ability to release Ca2+. Energy derives from cellular ATP as a result of mitochondrial activity. Mitochondria are themselves subject to redistribution and changes in activity during transition from the germinal vesicle to the metaphase II stage, in a fashion that can profoundly influence the quality of the mature oocyte and the destiny of the ensuing embryo. The dynamics of Golgi membranes during meiosis is still partially unknown but generally, as it occurs in the bovine, involves movements from the centre of the cytoplasm to the cortical area. Afterwards, a second translocation occurs between germinal vesicle breakdown and metaphase I stages, repositioning the Golgi from the periphery to the central cytoplasmic area.

Original languageEnglish
Title of host publicationOogenesis
PublisherSpringer-Verlag London Ltd
Pages209-217
Number of pages9
ISBN (Print)9780857298263, 9780857298256
DOIs
Publication statusPublished - Jan 1 2013

Fingerprint

Organelles
Oocytes
Meiosis
Metaphase
Fertilization
Cytoplasm
Stored Messenger RNA
Aptitude
Cytoskeleton
Mitosis
Endoplasmic Reticulum
Mental Competency
Embryonic Development
Ovary
Mitochondria
Embryonic Structures
Adenosine Triphosphate
Membranes
Growth

Keywords

  • Calcium oscillations
  • Calreticulin
  • Cortical granules
  • Endoplasmic
  • IP receptor
  • Oocyte development
  • Oocyte maturation
  • reticulum

ASJC Scopus subject areas

  • Health Professions(all)
  • Medicine(all)

Cite this

De Santis, L., & Brevini, T. A. L. (2013). Organelle rearrangement in the maturing oocyte. In Oogenesis (pp. 209-217). Springer-Verlag London Ltd. https://doi.org/10.1007/978-0-85729-826-3_15

Organelle rearrangement in the maturing oocyte. / De Santis, Lucia; Brevini, Tiziana A L.

Oogenesis. Springer-Verlag London Ltd, 2013. p. 209-217.

Research output: Chapter in Book/Report/Conference proceedingChapter

De Santis, L & Brevini, TAL 2013, Organelle rearrangement in the maturing oocyte. in Oogenesis. Springer-Verlag London Ltd, pp. 209-217. https://doi.org/10.1007/978-0-85729-826-3_15
De Santis L, Brevini TAL. Organelle rearrangement in the maturing oocyte. In Oogenesis. Springer-Verlag London Ltd. 2013. p. 209-217 https://doi.org/10.1007/978-0-85729-826-3_15
De Santis, Lucia ; Brevini, Tiziana A L. / Organelle rearrangement in the maturing oocyte. Oogenesis. Springer-Verlag London Ltd, 2013. pp. 209-217
@inbook{0061137449a94c23ae7bd7cdb92decc6,
title = "Organelle rearrangement in the maturing oocyte",
abstract = "Mammalian oocytes acquire a series of competencies during follicular development that play critical roles at fertilization and subsequent stages of preimplantation embryonic development. Before the mammalian oocyte engages in the fertilization process, it must acquire an array of molecular and cellular assets defining its developmental potential. These properties specify competencies to complete meiosis and initiate mitosis. Meiotic maturation requires the acquisition both of nuclear and cytoplasmic competence and this complex mechanism involves most of the organelles, the cytoskeleton and molecules that are relocated from the nucleus to the cytoplasm. Messenger RNAs of maternal origin are accumulated in the oocyte throughout its growth in the ovary. These transcripts are then shuttled to specific sites of the ooplasm, where local translation is promoted. The nucleus as an organelle undergoes significant positional rearrangements during maturation. At the same time, the spindle changes its localization drifting from the cortical region to the centre of the oocyte and then back cortically. The endoplasmic reticulum undergoes significant changes during maturation in its distribution that reflect an enhanced ability to release Ca2+. Energy derives from cellular ATP as a result of mitochondrial activity. Mitochondria are themselves subject to redistribution and changes in activity during transition from the germinal vesicle to the metaphase II stage, in a fashion that can profoundly influence the quality of the mature oocyte and the destiny of the ensuing embryo. The dynamics of Golgi membranes during meiosis is still partially unknown but generally, as it occurs in the bovine, involves movements from the centre of the cytoplasm to the cortical area. Afterwards, a second translocation occurs between germinal vesicle breakdown and metaphase I stages, repositioning the Golgi from the periphery to the central cytoplasmic area.",
keywords = "Calcium oscillations, Calreticulin, Cortical granules, Endoplasmic, IP receptor, Oocyte development, Oocyte maturation, reticulum",
author = "{De Santis}, Lucia and Brevini, {Tiziana A L}",
year = "2013",
month = "1",
day = "1",
doi = "10.1007/978-0-85729-826-3_15",
language = "English",
isbn = "9780857298263",
pages = "209--217",
booktitle = "Oogenesis",
publisher = "Springer-Verlag London Ltd",

}

TY - CHAP

T1 - Organelle rearrangement in the maturing oocyte

AU - De Santis, Lucia

AU - Brevini, Tiziana A L

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Mammalian oocytes acquire a series of competencies during follicular development that play critical roles at fertilization and subsequent stages of preimplantation embryonic development. Before the mammalian oocyte engages in the fertilization process, it must acquire an array of molecular and cellular assets defining its developmental potential. These properties specify competencies to complete meiosis and initiate mitosis. Meiotic maturation requires the acquisition both of nuclear and cytoplasmic competence and this complex mechanism involves most of the organelles, the cytoskeleton and molecules that are relocated from the nucleus to the cytoplasm. Messenger RNAs of maternal origin are accumulated in the oocyte throughout its growth in the ovary. These transcripts are then shuttled to specific sites of the ooplasm, where local translation is promoted. The nucleus as an organelle undergoes significant positional rearrangements during maturation. At the same time, the spindle changes its localization drifting from the cortical region to the centre of the oocyte and then back cortically. The endoplasmic reticulum undergoes significant changes during maturation in its distribution that reflect an enhanced ability to release Ca2+. Energy derives from cellular ATP as a result of mitochondrial activity. Mitochondria are themselves subject to redistribution and changes in activity during transition from the germinal vesicle to the metaphase II stage, in a fashion that can profoundly influence the quality of the mature oocyte and the destiny of the ensuing embryo. The dynamics of Golgi membranes during meiosis is still partially unknown but generally, as it occurs in the bovine, involves movements from the centre of the cytoplasm to the cortical area. Afterwards, a second translocation occurs between germinal vesicle breakdown and metaphase I stages, repositioning the Golgi from the periphery to the central cytoplasmic area.

AB - Mammalian oocytes acquire a series of competencies during follicular development that play critical roles at fertilization and subsequent stages of preimplantation embryonic development. Before the mammalian oocyte engages in the fertilization process, it must acquire an array of molecular and cellular assets defining its developmental potential. These properties specify competencies to complete meiosis and initiate mitosis. Meiotic maturation requires the acquisition both of nuclear and cytoplasmic competence and this complex mechanism involves most of the organelles, the cytoskeleton and molecules that are relocated from the nucleus to the cytoplasm. Messenger RNAs of maternal origin are accumulated in the oocyte throughout its growth in the ovary. These transcripts are then shuttled to specific sites of the ooplasm, where local translation is promoted. The nucleus as an organelle undergoes significant positional rearrangements during maturation. At the same time, the spindle changes its localization drifting from the cortical region to the centre of the oocyte and then back cortically. The endoplasmic reticulum undergoes significant changes during maturation in its distribution that reflect an enhanced ability to release Ca2+. Energy derives from cellular ATP as a result of mitochondrial activity. Mitochondria are themselves subject to redistribution and changes in activity during transition from the germinal vesicle to the metaphase II stage, in a fashion that can profoundly influence the quality of the mature oocyte and the destiny of the ensuing embryo. The dynamics of Golgi membranes during meiosis is still partially unknown but generally, as it occurs in the bovine, involves movements from the centre of the cytoplasm to the cortical area. Afterwards, a second translocation occurs between germinal vesicle breakdown and metaphase I stages, repositioning the Golgi from the periphery to the central cytoplasmic area.

KW - Calcium oscillations

KW - Calreticulin

KW - Cortical granules

KW - Endoplasmic

KW - IP receptor

KW - Oocyte development

KW - Oocyte maturation

KW - reticulum

UR - http://www.scopus.com/inward/record.url?scp=84939936375&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939936375&partnerID=8YFLogxK

U2 - 10.1007/978-0-85729-826-3_15

DO - 10.1007/978-0-85729-826-3_15

M3 - Chapter

AN - SCOPUS:84939936375

SN - 9780857298263

SN - 9780857298256

SP - 209

EP - 217

BT - Oogenesis

PB - Springer-Verlag London Ltd

ER -