Organic brain syndromes and opioid administration for cancer pain

Augusto Caraceni, Cinzia Martini, Franco De Conno, Vittorio Ventafridda

Research output: Contribution to journalArticle


To clarify the range of potential etiologies that may contribute to organic brain syndrome in patients receiving systemic opioids for cancer pain, we describe 15 patients who presented this complication. In 11 cases, concomitant conditions were found that could contribute to the onset of organic brain syndrome. These data illustrate that multiple causes often play a role in the development of mental status changes in advanced cancer. Opioids are seldom the only causal factor implicated.

Original languageEnglish
Pages (from-to)527-533
Number of pages7
JournalJournal of Pain and Symptom Management
Issue number8
Publication statusPublished - 1994



  • Cancer pain
  • delirium
  • hallucination
  • opioid administration
  • organic brain syndrome

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology
  • Neurology
  • Nursing(all)

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