Abstract
The placental transfer of thallium was studied in rats treated with a toxic dose of thallium sulphate (10 mg Tl/kg b.wt. p.o.), as well as in animals injected intraperitoneally with 201Tl-labelled thallium in amounts as low as 2 micrograms Tl/rat. Rapid uptake and retention of thallium in both maternal and fetal organs were observed. The administration of potassium ferrihexacyanoferrate II (100 mg/kg b.wt. twice daily by gavage) to rats acutely intoxicated with thallium on day 17 of pregnancy resulted in significant decrease of thallium concentrations in various maternal tissues including brain, in the placenta as well as in the fetal liver and brain. Potassium ferrihexacyanoferrate II also reduced the mortality of pregnant animals in the 72-h interval after the intoxication.
| Original language | English |
|---|---|
| Pages (from-to) | 225-230 |
| Number of pages | 6 |
| Journal | Archives of toxicology. Supplement. Archiv fur Toxikologie. Supplement |
| Volume | 5 |
| Publication status | Published - 1982 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Organ/tissue disposition of thallium in pregnant rats. / Sabbioni, E.; Gregotti, C.; Edel, J.; Marafante, E.; Di Nucci, A.; Manzo, L.
In: Archives of toxicology. Supplement. Archiv fur Toxikologie. Supplement, Vol. 5, 1982, p. 225-230.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Organ/tissue disposition of thallium in pregnant rats.
AU - Sabbioni, E.
AU - Gregotti, C.
AU - Edel, J.
AU - Marafante, E.
AU - Di Nucci, A.
AU - Manzo, L.
PY - 1982
Y1 - 1982
N2 - The placental transfer of thallium was studied in rats treated with a toxic dose of thallium sulphate (10 mg Tl/kg b.wt. p.o.), as well as in animals injected intraperitoneally with 201Tl-labelled thallium in amounts as low as 2 micrograms Tl/rat. Rapid uptake and retention of thallium in both maternal and fetal organs were observed. The administration of potassium ferrihexacyanoferrate II (100 mg/kg b.wt. twice daily by gavage) to rats acutely intoxicated with thallium on day 17 of pregnancy resulted in significant decrease of thallium concentrations in various maternal tissues including brain, in the placenta as well as in the fetal liver and brain. Potassium ferrihexacyanoferrate II also reduced the mortality of pregnant animals in the 72-h interval after the intoxication.
AB - The placental transfer of thallium was studied in rats treated with a toxic dose of thallium sulphate (10 mg Tl/kg b.wt. p.o.), as well as in animals injected intraperitoneally with 201Tl-labelled thallium in amounts as low as 2 micrograms Tl/rat. Rapid uptake and retention of thallium in both maternal and fetal organs were observed. The administration of potassium ferrihexacyanoferrate II (100 mg/kg b.wt. twice daily by gavage) to rats acutely intoxicated with thallium on day 17 of pregnancy resulted in significant decrease of thallium concentrations in various maternal tissues including brain, in the placenta as well as in the fetal liver and brain. Potassium ferrihexacyanoferrate II also reduced the mortality of pregnant animals in the 72-h interval after the intoxication.
UR - http://www.scopus.com/inward/record.url?scp=0020018033&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020018033&partnerID=8YFLogxK
M3 - Article
C2 - 6954904
AN - SCOPUS:0020018033
VL - 5
SP - 225
EP - 230
JO - Archives of toxicology. Supplement. Archiv fur Toxikologie. Supplement
JF - Archives of toxicology. Supplement. Archiv fur Toxikologie. Supplement
SN - 0171-9750
ER -