Organ/tissue disposition of thallium in pregnant rats.

E. Sabbioni; C. Gregotti; J. Edel; E. Marafante; A. Di Nucci; L. Manzo

Organ/tissue disposition of thallium in pregnant rats.

E. Sabbioni, C. Gregotti, J. Edel, E. Marafante, A. Di Nucci, L. Manzo

Istituti Clinici Scientifici Maugeri Spa – Società Benefit

Research output: Contribution to journal › Article › peer-review

Abstract

The placental transfer of thallium was studied in rats treated with a toxic dose of thallium sulphate (10 mg Tl/kg b.wt. p.o.), as well as in animals injected intraperitoneally with 201Tl-labelled thallium in amounts as low as 2 micrograms Tl/rat. Rapid uptake and retention of thallium in both maternal and fetal organs were observed. The administration of potassium ferrihexacyanoferrate II (100 mg/kg b.wt. twice daily by gavage) to rats acutely intoxicated with thallium on day 17 of pregnancy resulted in significant decrease of thallium concentrations in various maternal tissues including brain, in the placenta as well as in the fetal liver and brain. Potassium ferrihexacyanoferrate II also reduced the mortality of pregnant animals in the 72-h interval after the intoxication.

Original language	English
Pages (from-to)	225-230
Number of pages	6
Journal	Archives of toxicology. Supplement. Archiv fur Toxikologie. Supplement
Volume	5
Publication status	Published - 1982

ASJC Scopus subject areas

Medicine(all)

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title = "Organ/tissue disposition of thallium in pregnant rats.",

abstract = "The placental transfer of thallium was studied in rats treated with a toxic dose of thallium sulphate (10 mg Tl/kg b.wt. p.o.), as well as in animals injected intraperitoneally with 201Tl-labelled thallium in amounts as low as 2 micrograms Tl/rat. Rapid uptake and retention of thallium in both maternal and fetal organs were observed. The administration of potassium ferrihexacyanoferrate II (100 mg/kg b.wt. twice daily by gavage) to rats acutely intoxicated with thallium on day 17 of pregnancy resulted in significant decrease of thallium concentrations in various maternal tissues including brain, in the placenta as well as in the fetal liver and brain. Potassium ferrihexacyanoferrate II also reduced the mortality of pregnant animals in the 72-h interval after the intoxication.",

author = "E. Sabbioni and C. Gregotti and J. Edel and E. Marafante and {Di Nucci}, A. and L. Manzo",

year = "1982",

language = "English",

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journal = "Archives of toxicology. Supplement. Archiv fur Toxikologie. Supplement",

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T1 - Organ/tissue disposition of thallium in pregnant rats.

AU - Sabbioni, E.

AU - Gregotti, C.

AU - Edel, J.

AU - Marafante, E.

AU - Di Nucci, A.

AU - Manzo, L.

PY - 1982

Y1 - 1982

N2 - The placental transfer of thallium was studied in rats treated with a toxic dose of thallium sulphate (10 mg Tl/kg b.wt. p.o.), as well as in animals injected intraperitoneally with 201Tl-labelled thallium in amounts as low as 2 micrograms Tl/rat. Rapid uptake and retention of thallium in both maternal and fetal organs were observed. The administration of potassium ferrihexacyanoferrate II (100 mg/kg b.wt. twice daily by gavage) to rats acutely intoxicated with thallium on day 17 of pregnancy resulted in significant decrease of thallium concentrations in various maternal tissues including brain, in the placenta as well as in the fetal liver and brain. Potassium ferrihexacyanoferrate II also reduced the mortality of pregnant animals in the 72-h interval after the intoxication.

AB - The placental transfer of thallium was studied in rats treated with a toxic dose of thallium sulphate (10 mg Tl/kg b.wt. p.o.), as well as in animals injected intraperitoneally with 201Tl-labelled thallium in amounts as low as 2 micrograms Tl/rat. Rapid uptake and retention of thallium in both maternal and fetal organs were observed. The administration of potassium ferrihexacyanoferrate II (100 mg/kg b.wt. twice daily by gavage) to rats acutely intoxicated with thallium on day 17 of pregnancy resulted in significant decrease of thallium concentrations in various maternal tissues including brain, in the placenta as well as in the fetal liver and brain. Potassium ferrihexacyanoferrate II also reduced the mortality of pregnant animals in the 72-h interval after the intoxication.

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