Organ/tissue disposition of thallium in pregnant rats.

E. Sabbioni, C. Gregotti, J. Edel, E. Marafante, A. Di Nucci, L. Manzo

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Abstract

The placental transfer of thallium was studied in rats treated with a toxic dose of thallium sulphate (10 mg Tl/kg b.wt. p.o.), as well as in animals injected intraperitoneally with 201Tl-labelled thallium in amounts as low as 2 micrograms Tl/rat. Rapid uptake and retention of thallium in both maternal and fetal organs were observed. The administration of potassium ferrihexacyanoferrate II (100 mg/kg b.wt. twice daily by gavage) to rats acutely intoxicated with thallium on day 17 of pregnancy resulted in significant decrease of thallium concentrations in various maternal tissues including brain, in the placenta as well as in the fetal liver and brain. Potassium ferrihexacyanoferrate II also reduced the mortality of pregnant animals in the 72-h interval after the intoxication.

Original languageEnglish
Pages (from-to)225-230
Number of pages6
JournalArchives of toxicology. Supplement. Archiv fur Toxikologie. Supplement
Volume5
Publication statusPublished - 1982

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sabbioni, E., Gregotti, C., Edel, J., Marafante, E., Di Nucci, A., & Manzo, L. (1982). Organ/tissue disposition of thallium in pregnant rats. Archives of toxicology. Supplement. Archiv fur Toxikologie. Supplement, 5, 225-230.